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The cytochrome P450 complement (CYPome) ofMycosphaerella graminicola / Alun W. Newsome; David Nelson; Andrew Corran; Steven Kelly; Diane Kelly

Biotechnology and Applied Biochemistry, Volume: 60, Issue: 1, Pages: 52 - 64

Swansea University Authors: Steven, Kelly, Diane, Kelly

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DOI (Published version): 10.1002/bab.1062

Abstract

Mycosphaerella graminicola is a key fungal pathogen of wheatand a major target for azole fungicides, many of whose centralmode of action is through inhibition of cytochrome P450 51(lanosterol 14α-demethylase) in the ergosterol biosyntheticpathway. The range of activities of other fungal CYPs isthoug...

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Published in: Biotechnology and Applied Biochemistry
ISSN: 08854513
Published: 2013
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URI: https://cronfa.swan.ac.uk/Record/cronfa15172
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Abstract: Mycosphaerella graminicola is a key fungal pathogen of wheatand a major target for azole fungicides, many of whose centralmode of action is through inhibition of cytochrome P450 51(lanosterol 14α-demethylase) in the ergosterol biosyntheticpathway. The range of activities of other fungal CYPs isthought to be a reflection of the differences between differentorganisms and their range of secondary metabolic pathwaysas a response to their niche environments, for example, in theproduction of mycotoxins. The present study collatesinformation from a range of databases, to classify the CYPsfound in M. graminicola and assign them an internationallyrecognized nomenclature, which, when referenced to therecent publication of the JGI version 2.0 genome model,creates a current, robust model for the CYP complement(CYPome) of M. graminicola. These CYPome data, whichexamined 82 CYPs and one pseudo-gene, may be utilized notonly to further characterize and describe the physiology of theorganism but also to enhance our understanding of CYPfunction and diversity.
Keywords: cytochromes P450, environmental biotechnology,
College: Swansea University Medical School
Issue: 1
Start Page: 52
End Page: 64