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The CentriMag Centrifugal Blood Pump as a Benchmark for In Vitro Testing of Hemocompatibility in Implantable Ventricular Assist Devices / Chris H.H. Chan; Ina Laura Pieper; Rebecca Hambly; Gemma Radley; Alyssa Jones; Yasmin Friedmann; Karl M. Hawkins; Stephen Westaby; Graham Foster; Catherine A. Thornton

Artificial Organs, Volume: 39, Issue: 2, Pages: 93 - 101

Swansea University Author: Thornton, Catherine

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DOI (Published version): 10.1111/aor.12351

Abstract

Implantable ventricular assist devices (VADs) have proven efficient in advanced heart failure patients as a bridge-to-transplant or destination therapy. However, VAD usage often leads to infection, bleeding and thrombosis, side effects attributable to the damage to blood cells and plasma proteins. W...

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Published in: Artificial Organs
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa18309
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Abstract: Implantable ventricular assist devices (VADs) have proven efficient in advanced heart failure patients as a bridge-to-transplant or destination therapy. However, VAD usage often leads to infection, bleeding and thrombosis, side effects attributable to the damage to blood cells and plasma proteins. We have shown previously that m Measuring haemolysis alone does not provide sufficient information to understand total blood damage, and research exploring the impact of currently available pumps on a wider range of blood cell types and plasma proteins such as von Willebrand factor (vWF) within blood is required to further our understanding of safer pump design. The extracorporeal CentriMag® has a haemolysis profile within published standards for haemolysis of NIH levels of less than 0.01 g/100 L at 100 mm Hg [1] but the effect on leukocytes, vWF multimers and platelets are unknown. Here, the CentriMag® was tested using bovine blood (n=15) under constant haemodynamic conditions in comparison to a static control in terms of total blood cell counts, haemolysis, leukocyte death, vWF multimers, microparticles, platelet activation and apoptosis. The significant difference of total blood damage compared to the static control, was that Although there was no significant difference in haemolysis, cell counts, platelet activation or apoptosis between pumped and static blood, the CentriMag® decreased the levels of healthy leukocytes (p<0.006), induced some leukocyte microparticles (p<10-5) and the level of high molecular weight of vWF multimers was significantly reduced in the CentriMag® compared to the static treatment (p<10-5) after 6 hours in vitro testing. Despite the leukocyte damage, microparticle formation and cleavage of vWF multimers, these results show that the CentriMag® is a haemocompatible pump which could be used as a standard control for in blood damage assays to inform the design for new implantable blood pumps.
College: Swansea University Medical School
Issue: 2
Start Page: 93
End Page: 101