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Validation of Optimal Fourier Rheometry for rapidly gelling materials and its application in the study of collagen gelation / D.J. Curtis; A. Holder; N. Badiei; J. Claypole; M. Walters; B. Thomas; M. Barrow; D. Deganello; M.R. Brown; P.R. Williams; K. Hawkins

Journal of Non-Newtonian Fluid Mechanics, Volume: 222, Pages: 253 - 259

Swansea University Author: Barrow, Matthew

Abstract

Rheological Gel Point measurements may incur errors in the case of rapid gelling systems due to the limitations of multiple frequency oscillatory shear techniques such as frequency sweeps and Fourier Transform Mechanical Spectroscopy, FTMS. These limitations are associated with sample mutation and d...

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Published in: Journal of Non-Newtonian Fluid Mechanics
ISSN: 0377-0257
Published: 2015
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa21980
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Abstract: Rheological Gel Point measurements may incur errors in the case of rapid gelling systems due to the limitations of multiple frequency oscillatory shear techniques such as frequency sweeps and Fourier Transform Mechanical Spectroscopy, FTMS. These limitations are associated with sample mutation and data interpolation. In the present paper we consider how an alternative rapid characterisation technique known as Optimal Fourier Rheometry, OFR, can be used to study a rapidly gelling material, namely collagen at near physiological temperatures. The OFR technique is validated using a model reference gelling system whose GP characteristics have been widely reported. An analysis of the susceptibility of OFR measurements to rheometrical artefacts is made prior to its use in the study of rapid gelling collagen gels formed over a range of physiologically relevant collagen concentrations. The results of this OFR study are the first measurements of the stress relaxation characteristics of collagen gels performed in a single rheological experiment.
Item Description: 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/).
College: College of Engineering
Start Page: 253
End Page: 259