No Cover Image

Journal article 307 views 38 downloads

Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD) / C.J. Nettle; L. Jenkins; D. Curtis; N. Badiei; K. Lewis; P.R. Williams; D.R. Daniels

Biorheology, Pages: 1 - 14

Swansea University Author: Daniels, Rob

Check full text

DOI (Published version): 10.3233/BIR-17141

Abstract

Linear rheology, simple mathematical modelling and Scanning Electron Microscopy (SEM) were used to investigate sputum samples from exacerbated Chronic Obstructive Pulmonary Disease (COPD) patients. Comparing the rheology of exacerbated COPD sputum with healthy sputum (not diagnosed with a respirator...

Full description

Published in: Biorheology
ISSN: 0006-355X 1878-5034
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa37592
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Linear rheology, simple mathematical modelling and Scanning Electron Microscopy (SEM) were used to investigate sputum samples from exacerbated Chronic Obstructive Pulmonary Disease (COPD) patients. Comparing the rheology of exacerbated COPD sputum with healthy sputum (not diagnosed with a respiratory disease) revealed significant differences in response to oscillatory shear and creep-recovery experiments, which highlights the potential clinical benefits of better understanding sputum viscoelasticity. A power law model was successfully fitted to experimental rheology data over the range of frequencies studied. For the first time, a comparison was made between clinical data, on the ratio between Forced Expiratory Volume (FEV1) and Forced Vital Capacity (FVC), and the power law index m obtained from rheology. This suggests that an important possible future application of this work is as a potential biomarker for COPD severity.
Keywords: Rheology, viscoelastic properties, Chronic Obstructive Pulmonary Disease
College: College of Engineering
Start Page: 1
End Page: 14