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Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes / Richard, Bracken

PLOS ONE, Volume: 13, Issue: 4, Start page: e0194750

Swansea University Author: Richard, Bracken

Abstract

IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and...

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Published in: PLOS ONE
ISSN: 1932-6203
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa39473
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2018-06-04T14:57:38.6619335</datestamp><bib-version>v2</bib-version><id>39473</id><entry>2018-04-18</entry><title>Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes</title><swanseaauthors><author><sid>f5da81cd18adfdedb2ccb845bddc12f7</sid><ORCID>0000-0002-6986-6449</ORCID><firstname>Richard</firstname><surname>Bracken</surname><name>Richard Bracken</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-04-18</date><deptcode>STSC</deptcode><abstract>IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and methodsSixty-four people with T1DM (13 females; age: 34 &#xB1; 8 years; HbA1c: 7.8 &#xB1; 1% (62 &#xB1; 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR &lt; 0.20 vs. &gt; 0.20 in relation to HbA1c.ResultsWe found significant relationships between kHR and HbA1c (&#x3B2; = -0.70, P &lt; 0.0001), age (&#x3B2; = -0.23, P = 0.03) and duration of diabetes (&#x3B2; = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P &lt; 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (&#x3B2; = 0.43, P &lt; 0.0001) and maximum power output relativized to bodyweight (&#x3B2; = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P &lt; 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).ConclusionOur data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM.</abstract><type>Journal Article</type><journal>PLOS ONE</journal><volume>13</volume><journalNumber>4</journalNumber><paginationStart>e0194750</paginationStart><publisher/><issnElectronic>1932-6203</issnElectronic><keywords/><publishedDay>2</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-04-02</publishedDate><doi>10.1371/journal.pone.0194750</doi><url/><notes/><college>COLLEGE NANME</college><department>Sports Science</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><lastEdited>2018-06-04T14:57:38.6619335</lastEdited><Created>2018-04-18T14:33:21.8715970</Created><path><level id="1">College of Engineering</level><level id="2">Sports Science</level></path><authors><author><firstname>Othmar</firstname><surname>Moser</surname><order>1</order></author><author><firstname>Max L.</firstname><surname>Eckstein</surname><order>2</order></author><author><firstname>Olivia</firstname><surname>McCarthy</surname><order>3</order></author><author><firstname>Rachel</firstname><surname>Deere</surname><order>4</order></author><author><firstname>Stephen C.</firstname><surname>Bain</surname><order>5</order></author><author><firstname>Hanne L.</firstname><surname>Haahr</surname><order>6</order></author><author><firstname>Eric</firstname><surname>Zijlstra</surname><order>7</order></author><author><firstname>Tim</firstname><surname>Heise</surname><order>8</order></author><author><firstname>Richard</firstname><surname>Bracken</surname><orcid>0000-0002-6986-6449</orcid><order>9</order></author></authors><documents><document><filename>0039473-18042018143451.pdf</filename><originalFilename>moser2018(3)v2.pdf</originalFilename><uploaded>2018-04-18T14:34:51.9000000</uploaded><type>Output</type><contentLength>1430852</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><action/><embargoDate>2018-04-18T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents></rfc1807>
spelling 2018-06-04T14:57:38.6619335 v2 39473 2018-04-18 Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes f5da81cd18adfdedb2ccb845bddc12f7 0000-0002-6986-6449 Richard Bracken Richard Bracken true false 2018-04-18 STSC IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and methodsSixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c.ResultsWe found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).ConclusionOur data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM. Journal Article PLOS ONE 13 4 e0194750 1932-6203 2 4 2018 2018-04-02 10.1371/journal.pone.0194750 COLLEGE NANME Sports Science COLLEGE CODE STSC Swansea University 2018-06-04T14:57:38.6619335 2018-04-18T14:33:21.8715970 College of Engineering Sports Science Othmar Moser 1 Max L. Eckstein 2 Olivia McCarthy 3 Rachel Deere 4 Stephen C. Bain 5 Hanne L. Haahr 6 Eric Zijlstra 7 Tim Heise 8 Richard Bracken 0000-0002-6986-6449 9 0039473-18042018143451.pdf moser2018(3)v2.pdf 2018-04-18T14:34:51.9000000 Output 1430852 application/pdf Version of Record true 2018-04-18T00:00:00.0000000 true eng
title Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
spellingShingle Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
Richard, Bracken
title_short Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
title_full Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
title_fullStr Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
title_full_unstemmed Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
title_sort Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
author_id_str_mv f5da81cd18adfdedb2ccb845bddc12f7
author_id_fullname_str_mv f5da81cd18adfdedb2ccb845bddc12f7_***_Richard, Bracken
author Richard, Bracken
format Journal article
container_title PLOS ONE
container_volume 13
container_issue 4
container_start_page e0194750
publishDate 2018
institution Swansea University
issn 1932-6203
doi_str_mv 10.1371/journal.pone.0194750
college_str College of Engineering
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hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Sports Science{{{_:::_}}}College of Engineering{{{_:::_}}}Sports Science
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description IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and methodsSixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c.ResultsWe found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).ConclusionOur data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM.
published_date 2018-04-02T12:58:36Z
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