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An investigation of contact laws for coated pharmaceutical particles using the finite element method. / SU CHEONG

Swansea University Author: SU, CHEONG

Abstract

This research is inspired by the use of combined finite-discrete element method to model the compaction of coated drug particles during the tableting process. The use of extremely thin finite elements to represent the coatings proves to be inefficient as the use of explicit integration scheme in the...

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Published: 2006
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
URI: https://cronfa.swan.ac.uk/Record/cronfa42226
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Abstract: This research is inspired by the use of combined finite-discrete element method to model the compaction of coated drug particles during the tableting process. The use of extremely thin finite elements to represent the coatings proves to be inefficient as the use of explicit integration scheme in the simulation requires that each time step to be less than the critical time step that is determined from the smallest element size used in the simulation. Therefore, this research aims to overcome the problem of computational cost by formulating empirical interaction/contact laws (force-penetration relation) for coated particles to be incorporated into the simulation so that there is no need to model the coatings physically in the simulation. The contact between two coated particles is studied with the aid of finite element simulation by using a FE software package ELFEN. Elastic and plastic coatings are investigated, and adhesion is also included at the contact between plastic coatings. The formulated contact laws have made use of the material factor that successfully uncouple the influence of the coating material properties from the determination of other parameters, and provides a straightforward formulation that relates the contact force and the penetration. Comparisons between the formulated contact laws and the FE results show that the contact laws are able to approximate the contact behaviour of coated particles with good accuracy.
Keywords: Pharmaceutical sciences.
College: College of Engineering