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Polyastaxanthin-based coatings reduce bacterial colonization in vivo

Sagiv Weintraub, Llinos.G. Harris, Karin Thevissen, Dan.Y. Lewitus, Llinos Harris Orcid Logo

Materialia, Volume: 3, Pages: 15 - 20

Swansea University Author: Llinos Harris Orcid Logo

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Abstract

Polyastaxanthin p(ATX) is a family of polymers synthesized from the carotenoid astaxanthin and various dicarboxylic acids, resulting in moldable, high MW polymers, that can be made biodegradable. p(ATX) has previously shown to have antimicrobial properties in vitro, including inhibition of biofilm f...

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Published in: Materialia
ISSN: 25891529
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa45870
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first_indexed 2018-11-12T14:23:56Z
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spelling 2019-02-19T16:56:36.2363200 v2 45870 2018-11-12 Polyastaxanthin-based coatings reduce bacterial colonization in vivo dc70f9d4badbbdb5d467fd321986d173 0000-0002-0295-3038 Llinos Harris Llinos Harris true false 2018-11-12 BMS Polyastaxanthin p(ATX) is a family of polymers synthesized from the carotenoid astaxanthin and various dicarboxylic acids, resulting in moldable, high MW polymers, that can be made biodegradable. p(ATX) has previously shown to have antimicrobial properties in vitro, including inhibition of biofilm formation of S. epidermidis 1457, S. aureus MRSA252 and S. aureus MSSA476. In this work, we characterized the in vivo performance of p(ATX). Several in vivo evaluations were performed by implanting polyurethane catheter sections coated with pATXs in immunodeficient mice, followed by infection with S. aureus ATCC 6538. The polymer's capacity to inhibit bacterial biofilm formation on catheters was assessed. Two insights were generated. First, pATX has the capacity to significantly reduce the bacterial burden on coated catheters compared to uncoated catheters. Second, control over the biodegradation rate of the pATX, achieved via the use of hydrophilic diacid-comonomers, is required to allow long term antimicrobial properties for at least 96h. We found that slower degrading polymer are more beneficial in reducing bacterial load compared to rapidly degrading polymers, which begin to degrade immediately once hydrated. Thus, pATX, when appropriately designed, has the potential to perform as an antimicrobial coating formedical devices. Journal Article Materialia 3 15 20 25891529 p(ATX); in vivo; catheter; bacteria; antimicrobial 30 11 2018 2018-11-30 10.1016/j.mtla.2018.10.002 https://www.sciencedirect.com/science/article/pii/S2589152918301716?via%3Dihub COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2019-02-19T16:56:36.2363200 2018-11-12T09:42:43.9812664 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Sagiv Weintraub 1 Llinos.G. Harris 2 Karin Thevissen 3 Dan.Y. Lewitus 4 Llinos Harris 0000-0002-0295-3038 5
title Polyastaxanthin-based coatings reduce bacterial colonization in vivo
spellingShingle Polyastaxanthin-based coatings reduce bacterial colonization in vivo
Llinos Harris
title_short Polyastaxanthin-based coatings reduce bacterial colonization in vivo
title_full Polyastaxanthin-based coatings reduce bacterial colonization in vivo
title_fullStr Polyastaxanthin-based coatings reduce bacterial colonization in vivo
title_full_unstemmed Polyastaxanthin-based coatings reduce bacterial colonization in vivo
title_sort Polyastaxanthin-based coatings reduce bacterial colonization in vivo
author_id_str_mv dc70f9d4badbbdb5d467fd321986d173
author_id_fullname_str_mv dc70f9d4badbbdb5d467fd321986d173_***_Llinos Harris
author Llinos Harris
author2 Sagiv Weintraub
Llinos.G. Harris
Karin Thevissen
Dan.Y. Lewitus
Llinos Harris
format Journal article
container_title Materialia
container_volume 3
container_start_page 15
publishDate 2018
institution Swansea University
issn 25891529
doi_str_mv 10.1016/j.mtla.2018.10.002
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url https://www.sciencedirect.com/science/article/pii/S2589152918301716?via%3Dihub
document_store_str 0
active_str 0
description Polyastaxanthin p(ATX) is a family of polymers synthesized from the carotenoid astaxanthin and various dicarboxylic acids, resulting in moldable, high MW polymers, that can be made biodegradable. p(ATX) has previously shown to have antimicrobial properties in vitro, including inhibition of biofilm formation of S. epidermidis 1457, S. aureus MRSA252 and S. aureus MSSA476. In this work, we characterized the in vivo performance of p(ATX). Several in vivo evaluations were performed by implanting polyurethane catheter sections coated with pATXs in immunodeficient mice, followed by infection with S. aureus ATCC 6538. The polymer's capacity to inhibit bacterial biofilm formation on catheters was assessed. Two insights were generated. First, pATX has the capacity to significantly reduce the bacterial burden on coated catheters compared to uncoated catheters. Second, control over the biodegradation rate of the pATX, achieved via the use of hydrophilic diacid-comonomers, is required to allow long term antimicrobial properties for at least 96h. We found that slower degrading polymer are more beneficial in reducing bacterial load compared to rapidly degrading polymers, which begin to degrade immediately once hydrated. Thus, pATX, when appropriately designed, has the potential to perform as an antimicrobial coating formedical devices.
published_date 2018-11-30T03:57:30Z
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score 10.99342