Journal article 706 views
Polyastaxanthin-based coatings reduce bacterial colonization in vivo
Materialia, Volume: 3, Pages: 15 - 20
Swansea University Author: Llinos Harris
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DOI (Published version): 10.1016/j.mtla.2018.10.002
Abstract
Polyastaxanthin p(ATX) is a family of polymers synthesized from the carotenoid astaxanthin and various dicarboxylic acids, resulting in moldable, high MW polymers, that can be made biodegradable. p(ATX) has previously shown to have antimicrobial properties in vitro, including inhibition of biofilm f...
Published in: | Materialia |
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ISSN: | 25891529 |
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2018
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URI: | https://cronfa.swan.ac.uk/Record/cronfa45870 |
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2019-02-19T16:56:36.2363200 v2 45870 2018-11-12 Polyastaxanthin-based coatings reduce bacterial colonization in vivo dc70f9d4badbbdb5d467fd321986d173 0000-0002-0295-3038 Llinos Harris Llinos Harris true false 2018-11-12 BMS Polyastaxanthin p(ATX) is a family of polymers synthesized from the carotenoid astaxanthin and various dicarboxylic acids, resulting in moldable, high MW polymers, that can be made biodegradable. p(ATX) has previously shown to have antimicrobial properties in vitro, including inhibition of biofilm formation of S. epidermidis 1457, S. aureus MRSA252 and S. aureus MSSA476. In this work, we characterized the in vivo performance of p(ATX). Several in vivo evaluations were performed by implanting polyurethane catheter sections coated with pATXs in immunodeficient mice, followed by infection with S. aureus ATCC 6538. The polymer's capacity to inhibit bacterial biofilm formation on catheters was assessed. Two insights were generated. First, pATX has the capacity to significantly reduce the bacterial burden on coated catheters compared to uncoated catheters. Second, control over the biodegradation rate of the pATX, achieved via the use of hydrophilic diacid-comonomers, is required to allow long term antimicrobial properties for at least 96h. We found that slower degrading polymer are more beneficial in reducing bacterial load compared to rapidly degrading polymers, which begin to degrade immediately once hydrated. Thus, pATX, when appropriately designed, has the potential to perform as an antimicrobial coating formedical devices. Journal Article Materialia 3 15 20 25891529 p(ATX); in vivo; catheter; bacteria; antimicrobial 30 11 2018 2018-11-30 10.1016/j.mtla.2018.10.002 https://www.sciencedirect.com/science/article/pii/S2589152918301716?via%3Dihub COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2019-02-19T16:56:36.2363200 2018-11-12T09:42:43.9812664 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Sagiv Weintraub 1 Llinos.G. Harris 2 Karin Thevissen 3 Dan.Y. Lewitus 4 Llinos Harris 0000-0002-0295-3038 5 |
title |
Polyastaxanthin-based coatings reduce bacterial colonization in vivo |
spellingShingle |
Polyastaxanthin-based coatings reduce bacterial colonization in vivo Llinos Harris |
title_short |
Polyastaxanthin-based coatings reduce bacterial colonization in vivo |
title_full |
Polyastaxanthin-based coatings reduce bacterial colonization in vivo |
title_fullStr |
Polyastaxanthin-based coatings reduce bacterial colonization in vivo |
title_full_unstemmed |
Polyastaxanthin-based coatings reduce bacterial colonization in vivo |
title_sort |
Polyastaxanthin-based coatings reduce bacterial colonization in vivo |
author_id_str_mv |
dc70f9d4badbbdb5d467fd321986d173 |
author_id_fullname_str_mv |
dc70f9d4badbbdb5d467fd321986d173_***_Llinos Harris |
author |
Llinos Harris |
author2 |
Sagiv Weintraub Llinos.G. Harris Karin Thevissen Dan.Y. Lewitus Llinos Harris |
format |
Journal article |
container_title |
Materialia |
container_volume |
3 |
container_start_page |
15 |
publishDate |
2018 |
institution |
Swansea University |
issn |
25891529 |
doi_str_mv |
10.1016/j.mtla.2018.10.002 |
college_str |
Faculty of Medicine, Health and Life Sciences |
hierarchytype |
|
hierarchy_top_id |
facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
url |
https://www.sciencedirect.com/science/article/pii/S2589152918301716?via%3Dihub |
document_store_str |
0 |
active_str |
0 |
description |
Polyastaxanthin p(ATX) is a family of polymers synthesized from the carotenoid astaxanthin and various dicarboxylic acids, resulting in moldable, high MW polymers, that can be made biodegradable. p(ATX) has previously shown to have antimicrobial properties in vitro, including inhibition of biofilm formation of S. epidermidis 1457, S. aureus MRSA252 and S. aureus MSSA476. In this work, we characterized the in vivo performance of p(ATX). Several in vivo evaluations were performed by implanting polyurethane catheter sections coated with pATXs in immunodeficient mice, followed by infection with S. aureus ATCC 6538. The polymer's capacity to inhibit bacterial biofilm formation on catheters was assessed. Two insights were generated. First, pATX has the capacity to significantly reduce the bacterial burden on coated catheters compared to uncoated catheters. Second, control over the biodegradation rate of the pATX, achieved via the use of hydrophilic diacid-comonomers, is required to allow long term antimicrobial properties for at least 96h. We found that slower degrading polymer are more beneficial in reducing bacterial load compared to rapidly degrading polymers, which begin to degrade immediately once hydrated. Thus, pATX, when appropriately designed, has the potential to perform as an antimicrobial coating formedical devices. |
published_date |
2018-11-30T03:57:30Z |
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1763752910174289920 |
score |
11.028886 |