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Subjective Cognitive Impairment in 55-65-Year-Old Adults Is Associated with Negative Affective Symptoms, Neuroticism, and Poor Quality of Life / Amy Jenkins; Jeremy J. Tree; Ian M. Thornton; Andrea Tales

Journal of Alzheimer's Disease, Volume: 67, Issue: 4, Pages: 1367 - 1378

Swansea University Author: Jenkins, Amy

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DOI (Published version): 10.3233/JAD-180810

Abstract

Although subjective cognitive impairment (SCI) is increasingly recognized clinically and in research as a riskfactor for mild cognitive impairment and dementia (particularly Alzheimer’s disease), it is etiologically heterogeneousand potentially treatable. Compared to mild cognitive impairment and Al...

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Published in: Journal of Alzheimer's Disease
ISSN: 13872877 18758908
Published: IOS Press 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa49158
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Abstract: Although subjective cognitive impairment (SCI) is increasingly recognized clinically and in research as a riskfactor for mild cognitive impairment and dementia (particularly Alzheimer’s disease), it is etiologically heterogeneousand potentially treatable. Compared to mild cognitive impairment and Alzheimer’s disease, SCI however remains poorlycharacterized with debate continuing regarding its clinical relevance. The primary aim of this study was to improve thecharacterization of SCI within the general public by investigating functions sometimes omitted clinically or in research, namelyvisual attention-related information processing speed (RT) and its intra-individual variability (IIVRT), general cognition,depression, anxiety, memory, quality of life (QOL), and neuroticism. Compared to individuals without SCI, those with SCIwere more likely to reveal higher scores of anxiety, depression, and neuroticism and poorer perceived physical, psychological,and environmental QOL.Within-group analysis identified no significant relationships between any of the above variables forthe non-SCI group whereas for the SCI group, poorer Cognitive Change Index scores were significantly correlated with slowerRT, raised IIVRT, poorer memory, negative affective symptoms, higher neuroticism scores, and poorer QOL. This indicatesthat reports of perceived memory changes in SCI can also be associated with other characteristics, namely objectivelymeasured detrimental change in other aspects of brain function and behavior. This outcome emphasizes the importance ofa multi-function approach to characterizing and understanding SCI. Thus, although the effect of RT and IIVRT is not strongenough to differentiate SCI from non-SCI at group level, slowing and raised IIVRT do appear to characterize some peoplewith SCI.
Keywords: Anxiety, dementia, depression, memory, neuroticism, quality of life, reaction time, subjective cognitive impairment, visual attention
College: College of Human and Health Sciences
Issue: 4
Start Page: 1367
End Page: 1378