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Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes / Othmar Moser; Max L. Eckstein; Olivia McCarthy; Rachel Deere; Stephen C. Bain; Hanne L. Haahr; Eric Zijlstra; Tim Heise; Richard M. Bracken

PLOS ONE, Volume: 13, Issue: 4, Start page: e0194750

Swansea University Author: Bracken, Richard

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Abstract

IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and...

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Published in: PLOS ONE
ISSN: 1932-6203
Published: 2018
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-07-29T10:21:06Z</datestamp><bib-version>v2</bib-version><id>49758</id><entry>2019-03-26</entry><title>Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes</title><alternativeTitle></alternativeTitle><author>Richard Bracken</author><firstname>Richard</firstname><surname>Bracken</surname><active>true</active><ORCID>0000-0002-6986-6449</ORCID><ethesisStudent>false</ethesisStudent><sid>f5da81cd18adfdedb2ccb845bddc12f7</sid><email>c2f12190ee439c0b43c81a7e4080b512</email><emailaddr>3Wdnxc03MzLF9YK+G8SHrhXCE6Z9OGBXOD9D5JU4+T4=</emailaddr><date>2019-03-26</date><deptcode>STSC</deptcode><abstract>IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and methodsSixty-four people with T1DM (13 females; age: 34 &#xB1; 8 years; HbA1c: 7.8 &#xB1; 1% (62 &#xB1; 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR &lt; 0.20 vs. &gt; 0.20 in relation to HbA1c.ResultsWe found significant relationships between kHR and HbA1c (&#x3B2; = -0.70, P &lt; 0.0001), age (&#x3B2; = -0.23, P = 0.03) and duration of diabetes (&#x3B2; = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P &lt; 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (&#x3B2; = 0.43, P &lt; 0.0001) and maximum power output relativized to bodyweight (&#x3B2; = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P &lt; 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).ConclusionOur data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM.</abstract><type>Journal article</type><journal>PLOS ONE</journal><volume>13</volume><journalNumber>4</journalNumber><paginationStart>e0194750</paginationStart><paginationEnd/><publisher></publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>1932-6203</issnElectronic><keywords></keywords><publishedDay>0</publishedDay><publishedMonth>0</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-01-01</publishedDate><doi>10.1371/journal.pone.0194750</doi><url></url><notes></notes><college>College of Engineering</college><department>Sports Science</department><CollegeCode>CENG</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution/><researchGroup>Applied Sports Technology Exercise and Medicine Research Centre</researchGroup><supervisor/><sponsorsfunders/><grantnumber/><degreelevel/><degreename>None</degreename><lastEdited>2019-07-29T10:21:06Z</lastEdited><Created>2019-03-26T16:54:28Z</Created><path><level id="1">College of Engineering</level><level id="2">Sports Science</level></path><authors><author><firstname>Othmar</firstname><surname>Moser</surname><orcid/><order>1</order></author><author><firstname>Max L.</firstname><surname>Eckstein</surname><orcid/><order>2</order></author><author><firstname>Olivia</firstname><surname>McCarthy</surname><orcid/><order>3</order></author><author><firstname>Rachel</firstname><surname>Deere</surname><orcid/><order>4</order></author><author><firstname>Stephen C.</firstname><surname>Bain</surname><orcid/><order>5</order></author><author><firstname>Hanne L.</firstname><surname>Haahr</surname><orcid/><order>6</order></author><author><firstname>Eric</firstname><surname>Zijlstra</surname><orcid/><order>7</order></author><author><firstname>Tim</firstname><surname>Heise</surname><orcid/><order>8</order></author><author><firstname>Richard M.</firstname><surname>Bracken</surname><orcid/><order>9</order></author></authors><documents><document><filename>0049758-13052019103836.pdf</filename><originalFilename>moser2019(3).pdf</originalFilename><uploaded>2019-05-13T10:38:36Z</uploaded><type>Output</type><contentLength>3461211</contentLength><contentType>application/pdf</contentType><version>VoR</version><cronfaStatus>true</cronfaStatus><action>Updated Copyright</action><actionDate>18/07/2019</actionDate><embargoDate>2019-05-13T00:00:00</embargoDate><documentNotes>Distributed under the terms of a Creative Commons Attribution (CC-BY-4.0)</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents></rfc1807>
spelling 2019-07-29T10:21:06Z v2 49758 2019-03-26 Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes Richard Bracken Richard Bracken true 0000-0002-6986-6449 false f5da81cd18adfdedb2ccb845bddc12f7 c2f12190ee439c0b43c81a7e4080b512 3Wdnxc03MzLF9YK+G8SHrhXCE6Z9OGBXOD9D5JU4+T4= 2019-03-26 STSC IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and methodsSixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c.ResultsWe found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).ConclusionOur data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM. Journal article PLOS ONE 13 4 e0194750 1932-6203 0 0 2018 2018-01-01 10.1371/journal.pone.0194750 College of Engineering Sports Science CENG STSC Applied Sports Technology Exercise and Medicine Research Centre None 2019-07-29T10:21:06Z 2019-03-26T16:54:28Z College of Engineering Sports Science Othmar Moser 1 Max L. Eckstein 2 Olivia McCarthy 3 Rachel Deere 4 Stephen C. Bain 5 Hanne L. Haahr 6 Eric Zijlstra 7 Tim Heise 8 Richard M. Bracken 9 0049758-13052019103836.pdf moser2019(3).pdf 2019-05-13T10:38:36Z Output 3461211 application/pdf VoR true Updated Copyright 18/07/2019 2019-05-13T00:00:00 Distributed under the terms of a Creative Commons Attribution (CC-BY-4.0) true eng
title Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
spellingShingle Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
Bracken, Richard
title_short Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
title_full Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
title_fullStr Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
title_full_unstemmed Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
title_sort Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
author_id_str_mv f5da81cd18adfdedb2ccb845bddc12f7
author_id_fullname_str_mv f5da81cd18adfdedb2ccb845bddc12f7_***_Bracken, Richard
author Bracken, Richard
author2 Othmar Moser
Max L. Eckstein
Olivia McCarthy
Rachel Deere
Stephen C. Bain
Hanne L. Haahr
Eric Zijlstra
Tim Heise
Richard M. Bracken
format Journal article
container_title PLOS ONE
container_volume 13
container_issue 4
container_start_page e0194750
publishDate 2018
institution Swansea University
issn 1932-6203
doi_str_mv 10.1371/journal.pone.0194750
college_str College of Engineering
hierarchytype
hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Sports Science{{{_:::_}}}College of Engineering{{{_:::_}}}Sports Science
document_store_str 1
active_str 1
researchgroup_str Applied Sports Technology Exercise and Medicine Research Centre
description IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and methodsSixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ± 1% (62 ± 13 mmol.mol-1) performed a CPX test until maximum exhaustion. kHR was calculated by a second-degree polynomial representation between post-warm up and maximum power output. Adjusted stepwise linear regression analysis was performed to investigate kHR and its associations. Receiver operating characteristic (ROC) curve was performed based on kHR for groups kHR < 0.20 vs. > 0.20 in relation to HbA1c.ResultsWe found significant relationships between kHR and HbA1c (β = -0.70, P < 0.0001), age (β = -0.23, P = 0.03) and duration of diabetes (β = 0.20, P = 0.04). Stepwise linear regression resulted in an overall adjusted R2 of 0.57 (R = 0.79, P < 0.0001). Our data revealed also significant associations between kHR and percentage of heart rate at heart rate turn point from maximum heart rate (β = 0.43, P < 0.0001) and maximum power output relativized to bodyweight (β = 0.44, P = 0.001) (overall adjusted R2 of 0.44 (R = 0.53, P < 0.0001)). ROC curve analysis based on kHR resulted in a HbA1c threshold of 7.9% (62 mmol.mol-1).ConclusionOur data demonstrate atypical HRPC during CPX testing that were mainly related to glycemic control in people with T1DM.
published_date 2018-01-01T05:17:39Z
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