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Ghrelin function in human obesity and type 2 diabetes: a concise review / R Churm; JS Davies; JW Stephens; SL Prior

Obesity Reviews, Volume: 18, Issue: 2, Pages: 140 - 148

Swansea University Author: Churm, Rachel

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DOI (Published version): 10.1111/obr.12474

Abstract

The 28 amino acid hormone, ghrelin has been found to have various effects on metabolism. This review will focus on the pathways integrated into ghrelin’s effect within the hypothalamus, pancreas and adipocytes. The identification of molecules and pathways that regulate ghrelin mediated lipid retenti...

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Published in: Obesity Reviews
ISSN: 14677881
Published: 2017
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa50667
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Abstract: The 28 amino acid hormone, ghrelin has been found to have various effects on metabolism. This review will focus on the pathways integrated into ghrelin’s effect within the hypothalamus, pancreas and adipocytes. The identification of molecules and pathways that regulate ghrelin mediated lipid retention could establish new mechanisms underlying cellular energy homeostasis. The impact of acyl-ghrelin on glucose metabolism and lipid homeostasis may allow for novel preventative or early intervention therapeutic strategies to treat obesity related type 2 diabetes and associated metabolic dysfunction.
Keywords: Ghrelin, Obesity, Type 2 diabetes
College: Swansea University Medical School
Issue: 2
Start Page: 140
End Page: 148