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Early and late mortality following unscheduled admissions for severe liver disease across England and Wales / Stephen E. Roberts; Ann John; Jonathan Brown; Duncan J. Napier; Ronan A. Lyons; John G. Williams

Alimentary Pharmacology & Therapeutics, Volume: 49, Issue: 10, Pages: 1334 - 1345

Swansea University Author: Williams, John

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DOI (Published version): 10.1111/apt.15232

Abstract

Early (60 day) and late (5 year) mortality following acute hospital admission with severe liver disease has bee investigated using hospital episode statistics from England and Wales from 2004 to 2012. Mortality for alcoholic liver disease and hepatic failure was 23.4% and 35.4% respectively at 60 da...

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Published in: Alimentary Pharmacology & Therapeutics
ISSN: 02692813
Published: Wiley 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa51129
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Abstract: Early (60 day) and late (5 year) mortality following acute hospital admission with severe liver disease has bee investigated using hospital episode statistics from England and Wales from 2004 to 2012. Mortality for alcoholic liver disease and hepatic failure was 23.4% and 35.4% respectively at 60 days and 61.8% and 57.1% at 5 years. Standardised mortality ratios (SMRs) were very high at 60 days (184 and 117 respectively) and remained increased at 5 years (16.7 and 6.3). Mortality at 5 years was most elevated from liver disease, viral hepatitis and varices. The 60‐day mortality was significantly lower for patients seen by consultant hepatologists and gastroenterolo- gists. Both early and late mortality were significantly reduced for patients admitted to transplant centres or larger hospitals, who received a liver transplant, or were res- ident in London. Early mortality was significantly higher for patients admitted in winter and autumn.
Keywords: Severe liver disease; acute admission; mortality; alcohol
College: Swansea University Medical School
Issue: 10
Start Page: 1334
End Page: 1345