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Early and late mortality following unscheduled admissions for severe liver disease across England and Wales / Stephen E. Roberts; Ann John; Jonathan Brown; Duncan J. Napier; Ronan A. Lyons; John G. Williams

Alimentary Pharmacology & Therapeutics, Volume: 49, Issue: 10, Pages: 1334 - 1345

Swansea University Author: Williams, John

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DOI (Published version): 10.1111/apt.15232

Abstract

Early (60 day) and late (5 year) mortality following acute hospital admission with severe liver disease has bee investigated using hospital episode statistics from England and Wales from 2004 to 2012. Mortality for alcoholic liver disease and hepatic failure was 23.4% and 35.4% respectively at 60 da...

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Published in: Alimentary Pharmacology & Therapeutics
ISSN: 02692813
Published: Wiley 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa51129
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first_indexed 2019-07-18T15:40:13Z
last_indexed 2019-08-09T16:31:23Z
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spelling 2019-08-09T14:16:20Z v2 51129 2019-07-18 Early and late mortality following unscheduled admissions for severe liver disease across England and Wales John Williams John Williams true 0000-0002-7015-9055 false 911a5c03419acf47eab0844e2cd5ab7f 7b54fabf31ed78a964833d0557b31ab2 42BkKF7HpxaFC9KrQkCoVX2HZhUyFASdV1DFdgIIhKs= 2019-07-18 PMSC Early (60 day) and late (5 year) mortality following acute hospital admission with severe liver disease has bee investigated using hospital episode statistics from England and Wales from 2004 to 2012. Mortality for alcoholic liver disease and hepatic failure was 23.4% and 35.4% respectively at 60 days and 61.8% and 57.1% at 5 years. Standardised mortality ratios (SMRs) were very high at 60 days (184 and 117 respectively) and remained increased at 5 years (16.7 and 6.3). Mortality at 5 years was most elevated from liver disease, viral hepatitis and varices. The 60‐day mortality was significantly lower for patients seen by consultant hepatologists and gastroenterolo- gists. Both early and late mortality were significantly reduced for patients admitted to transplant centres or larger hospitals, who received a liver transplant, or were res- ident in London. Early mortality was significantly higher for patients admitted in winter and autumn. Journal article Alimentary Pharmacology & Therapeutics 49 10 1334 1345 Wiley 02692813 Severe liver disease; acute admission; mortality; alcohol 0 5 2019 2019-05-01 10.1111/apt.15232 Swansea University Medical School Medicine CMED PMSC Patient & population health and informatics None 2019-08-09T14:16:20Z 2019-07-18T12:45:21Z Swansea University Medical School Medicine Stephen E. Roberts 1 Ann John 2 Jonathan Brown 3 Duncan J. Napier 4 Ronan A. Lyons 5 John G. Williams 6 0051129-09082019141536.pdf 51129.pdf 2019-08-09T14:15:36Z Output 748207 application/pdf VoR true Published to Cronfa 09/08/2019 2019-08-08T00:00:00 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng
title Early and late mortality following unscheduled admissions for severe liver disease across England and Wales
spellingShingle Early and late mortality following unscheduled admissions for severe liver disease across England and Wales
Williams, John
title_short Early and late mortality following unscheduled admissions for severe liver disease across England and Wales
title_full Early and late mortality following unscheduled admissions for severe liver disease across England and Wales
title_fullStr Early and late mortality following unscheduled admissions for severe liver disease across England and Wales
title_full_unstemmed Early and late mortality following unscheduled admissions for severe liver disease across England and Wales
title_sort Early and late mortality following unscheduled admissions for severe liver disease across England and Wales
author_id_str_mv 911a5c03419acf47eab0844e2cd5ab7f
author_id_fullname_str_mv 911a5c03419acf47eab0844e2cd5ab7f_***_Williams, John
author Williams, John
author2 Stephen E. Roberts
Ann John
Jonathan Brown
Duncan J. Napier
Ronan A. Lyons
John G. Williams
format Journal article
container_title Alimentary Pharmacology & Therapeutics
container_volume 49
container_issue 10
container_start_page 1334
publishDate 2019
institution Swansea University
issn 02692813
doi_str_mv 10.1111/apt.15232
publisher Wiley
college_str Swansea University Medical School
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hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
document_store_str 1
active_str 1
researchgroup_str Patient & population health and informatics
description Early (60 day) and late (5 year) mortality following acute hospital admission with severe liver disease has bee investigated using hospital episode statistics from England and Wales from 2004 to 2012. Mortality for alcoholic liver disease and hepatic failure was 23.4% and 35.4% respectively at 60 days and 61.8% and 57.1% at 5 years. Standardised mortality ratios (SMRs) were very high at 60 days (184 and 117 respectively) and remained increased at 5 years (16.7 and 6.3). Mortality at 5 years was most elevated from liver disease, viral hepatitis and varices. The 60‐day mortality was significantly lower for patients seen by consultant hepatologists and gastroenterolo- gists. Both early and late mortality were significantly reduced for patients admitted to transplant centres or larger hospitals, who received a liver transplant, or were res- ident in London. Early mortality was significantly higher for patients admitted in winter and autumn.
published_date 2019-05-01T05:20:20Z
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