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Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure

GABRIELA FRIANI Orcid Logo, VALDIR A. COSTA Orcid Logo, ESTER MOTA Orcid Logo, MARTA JÚLIA FARO Orcid Logo, SAMALY SOUZA Orcid Logo, Marcela Barbosa Figueiredo Santangelo, PATRÍCIA S. GÔLO Orcid Logo, CLÉLIA CHRISTINA MELLO-SILVA Orcid Logo

Anais da Academia Brasileira de Ciências, Volume: 94, Issue: 2, Start page: e20190676

Swansea University Author: Marcela Barbosa Figueiredo Santangelo

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DOI (Published version): 10.1590/0001-3765202220200620

Abstract

Schistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni. The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathol...

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Published in: Anais da Academia Brasileira de Ciências
ISSN: 0001-3765 1678-2690
Published: FapUNIFESP (SciELO) 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa59555
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spelling 2022-03-09T12:39:54.5582823 v2 59555 2022-03-09 Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure b6d8f11df85fce6d8bd702f565908a79 Marcela Barbosa Figueiredo Santangelo Marcela Barbosa Figueiredo Santangelo true false 2022-03-09 PMSC Schistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni. The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathology of B. glabrata infected by S. mansoni. Uninfected and infected snails were exposed to sublethal concentration of E. milii latex for 24 hours (1.0 mg/L). The survival rate was 88.5% for the uninfected snails and 66.6% for the infected and exposed snails. In the snails infected by S. mansoni, the exposure to E. milii latex promoted proliferation of hemocytes in the tentacles, mantle, digestive gland and kidney. In the digestive gland and the kidney, granulomatous reactions occurred around the sporocysts and caused their destruction. The number of circulating hemocytes from the group infected and exposed to E. milii latex was significantly higher than in the other groups. Three types of hemocytes were found: hyalinocytes, granulocytes and blast-like cells. We conclude that the E. milii latex influenced the cellular immune response of the susceptible B. glabrata strain to infection by S. mansoni, promoting the destruction of parasites. Journal Article Anais da Academia Brasileira de Ciências 94 2 e20190676 FapUNIFESP (SciELO) 0001-3765 1678-2690 Biomphalaria glabrata; Euphorbia milii; hemocytes; phytochemical; susceptibility 18 2 2022 2022-02-18 10.1590/0001-3765202220200620 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior – Brasil (CAPES) - Finance code 001; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ- Bolsista nota 10 program) and Fundação Oswaldo Cruz (PAEF IOC-008 FIO-04). 2022-03-09T12:39:54.5582823 2022-03-09T12:34:38.0347555 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine GABRIELA FRIANI 0000-0002-1687-5608 1 VALDIR A. COSTA 0000-0003-0256-9308 2 ESTER MOTA 0000-0003-0712-3874 3 MARTA JÚLIA FARO 0000-0002-8080-3561 4 SAMALY SOUZA 0000-0002-9924-7067 5 Marcela Barbosa Figueiredo Santangelo 6 PATRÍCIA S. GÔLO 0000-0003-1854-7488 7 CLÉLIA CHRISTINA MELLO-SILVA 0000-0002-5575-2272 8 59555__22555__84e9a46a7b704cfc8b51f54554dd2ac6.pdf 59555.pdf 2022-03-09T12:38:03.8822386 Output 1556281 application/pdf Version of Record true This is an open-access article distributed under the terms of the Creative Commons Attribution License true eng https://creativecommons.org/licenses/by/4.0/
title Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
spellingShingle Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
Marcela Barbosa Figueiredo Santangelo
title_short Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
title_full Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
title_fullStr Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
title_full_unstemmed Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
title_sort Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure
author_id_str_mv b6d8f11df85fce6d8bd702f565908a79
author_id_fullname_str_mv b6d8f11df85fce6d8bd702f565908a79_***_Marcela Barbosa Figueiredo Santangelo
author Marcela Barbosa Figueiredo Santangelo
author2 GABRIELA FRIANI
VALDIR A. COSTA
ESTER MOTA
MARTA JÚLIA FARO
SAMALY SOUZA
Marcela Barbosa Figueiredo Santangelo
PATRÍCIA S. GÔLO
CLÉLIA CHRISTINA MELLO-SILVA
format Journal article
container_title Anais da Academia Brasileira de Ciências
container_volume 94
container_issue 2
container_start_page e20190676
publishDate 2022
institution Swansea University
issn 0001-3765
1678-2690
doi_str_mv 10.1590/0001-3765202220200620
publisher FapUNIFESP (SciELO)
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description Schistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni. The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathology of B. glabrata infected by S. mansoni. Uninfected and infected snails were exposed to sublethal concentration of E. milii latex for 24 hours (1.0 mg/L). The survival rate was 88.5% for the uninfected snails and 66.6% for the infected and exposed snails. In the snails infected by S. mansoni, the exposure to E. milii latex promoted proliferation of hemocytes in the tentacles, mantle, digestive gland and kidney. In the digestive gland and the kidney, granulomatous reactions occurred around the sporocysts and caused their destruction. The number of circulating hemocytes from the group infected and exposed to E. milii latex was significantly higher than in the other groups. Three types of hemocytes were found: hyalinocytes, granulocytes and blast-like cells. We conclude that the E. milii latex influenced the cellular immune response of the susceptible B. glabrata strain to infection by S. mansoni, promoting the destruction of parasites.
published_date 2022-02-18T04:16:57Z
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