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Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
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Kadie Edwards ,
Zoe Coombes,
Jetzabel Garcia,
Neil Garton,
Nagindra Das,
Kerryn Lutchman-Singh,
Lavinia Margarit,
Amy L. Beynon,
Inmaculada Rioja,
Rab K. Prinjha,
Nicola R. Harker,
Deyarina Gonzalez,
Steve Conlan ,
Lewis Francis
Clinical Epigenetics, Volume: 15, Issue: 1
Swansea University Authors:
Marcos Quintela Vazquez, David James, Agne Pociute, Lydia Powell , Kadie Edwards , Zoe Coombes, Kerryn Lutchman-Singh, Lavinia Margarit, Steve Conlan , Lewis Francis
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DOI (Published version): 10.1186/s13148-023-01477-x
Abstract
Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
| Published in: | Clinical Epigenetics |
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| ISSN: | 1868-7083 |
| Published: |
Springer Science and Business Media LLC
2023
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa63494 |
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| Keywords: |
Ovarian cancer, BETi , Advanced therapeutics, Drug development, i-BET858 |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
1 |