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Journal article

CELL DEATH INDUCED BY OVEREXPRESSION OF THE HUMAN CARDIAC RYANODINE RECEPTOR (hRYR2) CAN BE PREVENTED BY CO-EXPRESSION WITH FK506-BINDING PROTEIN 12.6 (FKBP12. 6) / Christopher George

Swansea University Author: Christopher George
Published in Heart (2001)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Effect of flecainide derivatives on sarcoplasmic reticulum Ca2+ release confirms a lack of direct action on the cardiac ryanodine receptor / Christopher George

Swansea University Author: Christopher George
Published in Biophysical Journal (2016)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

The mechanism of flecainide action in catecholaminergic polymorphic ventricular tachycardia does not involve a direct effect on the ryanodine receptor / Christopher George

Swansea University Author: Christopher George
Published in Proceedings of The Physiological Society (2015)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Fundamental gating defects of sudden cardiac death-linked mutant cardiac ryanodine receptors determine Ca2+ release dynamics in cells / Christopher George

Swansea University Author: Christopher George
Published in Proceedings of The Physiological Society (2015)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Site-directed mutagenesis of Serine 2815 on the cardiac ryanodine receptor and resultant effects on channel function / Christopher George

Swansea University Author: Christopher George
Published in Proceedings of The Physiological Society (2007)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Predictive Drug Toxicity Profiling using a New Mode of Calcium Signal Analysis in Human Es-Derived Cardiomyocytes / Christopher George

Swansea University Author: Christopher George
Published in Biophysical Journal (2014)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

The Metabolic Modulator Perhexiline Induces Calcium-Cycling Dysfunction and Apoptosis in Cardiomyocyte Syncytia / Christopher George

Swansea University Author: Christopher George
Published in Biophysical Journal (2014)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Transcriptional alterations mediated via dysregulated human cardiac ryanodine receptor (hRyR2). / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2003)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Ouabain is a Pharmacomimic of Mutant RyR2 Ca2+ Release Dysfunction but is not a Serum-Borne Trigger of CPVT / Christopher George

Swansea University Author: Christopher George
Published in Biophysical Journal (2011)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Characterisation of the human recombinant cardiac intracellular calcium release channel (ryanodine receptor). / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2004)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Expression of human RyR2 splice variants / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2003)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12. 6. / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2001)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Molecular mechanisms underlying RyR2 (Ca2+ release channel) dysfunction in stress-induced VT / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2004)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

In situ characterisation of the Ca2+ sensitivity of cardiac RyR mutations reveals multiple mechanisms of channel dysfunction in sudden death / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2005)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Visualisation of intra-RyR2 interactions in HL-1 cardiomyocytes: novel FRET probes reveal a structural basis for Ca2+ channel dysfunction in arrhythmogenesis. / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2005)

In collection: Faculty of Medicine, Health and Life Sciences

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Staff Thesis

Modulating intracellular Ca2+ signalling using recombinant fragments of the human cardiac ryanodine receptor (RyR2) / Christopher George

Swansea University Author: Christopher George
Published 2008

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Altered intra-RyR interaction associated with stress-induced ventricular tachycardia. / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2004)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Cytoplasmic Ca2+ spiking via human RyR2 mediates cell death / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2002)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

In situ regulation of the human cardiac ryanodine receptor (hRyR2) by intramolecular interaction / Christopher George

Swansea University Author: Christopher George
Published in Biophysical Journal (2002)

In collection: Faculty of Medicine, Health and Life Sciences

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Conference Paper/Proceeding/Abstract

Targeting the RyR2 I-domain as a novel strategy to correct mutationlinked Ca2+ release channel dysfunction. / Christopher George

Swansea University Author: Christopher George
Published in BIOPHYSICAL JOURNAL (2007)

In collection: Faculty of Medicine, Health and Life Sciences

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Format

109 Journal article 40 Conference Paper/Proceeding/Abstract 5 Book chapter 1 E-Thesis 1 Media 1 Patent more ... 1 Staff Thesis see all ... less ...

Author

118 Christopher George 13 Ronan Lyons 12 Nia Thomas 8 Alan Williams 5 Mark Bannister 4 Belinda Gabbe more ... 4 David Edwards 3 Gareth Stratton 3 John Wagstaff 2 Owen Pickrell 2 George Johnson 2 Steve Bain 2 Saptarshi Mukherjee 2 Robert Powell 2 Ashley Akbari 2 Sarah Prior 2 Andrew Kemp 1 Melitta McNarry 1 Bevan Cumbes 1 Luke Roberts 1 Jeffrey Davies 1 Jeremy Tree 1 Perumal Nithiarasu 1 Raluca Popa 1 Christopher George Dawson 1 Anthony Owen 1 Jeffrey Stephens 1 Paul Rees 1 Venkat Kanamarlapudi 1 Beata Fonferko-Shadrach see all ... less ...

Faculty

148 Faculty of Medicine, Health and Life Sciences 8 Faculty of Science and Engineering 1 Faculty of Humanities and Social Sciences see all ...

School

133 Swansea University Medical School - Medicine 7 Swansea University Medical School - Health Data Science 5 Swansea University Medical School - Biomedical Science 3 School of Engineering and Applied Sciences - Sport and Exercise Sciences 2 School of Psychology 1 School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering more ... 1 School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences 1 School of Biosciences, Geography and Physics - Biosciences 1 School of Engineering and Applied Sciences - Biomedical Engineering 1 School of Management - Economics 1 School of Mathematics and Computer Science - Computer Science 1 The Centre for Innovative Ageing see all ... less ...

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2026

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