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On the future of “omics”: lipidomics / William, Griffiths; Yuqin, Wang

Journal of Inherited Metabolic Disease, Volume: 34, Issue: 3, Pages: 583 - 592

Swansea University Authors: William, Griffiths, Yuqin, Wang

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Abstract

Following in the wake of the genomic and proteomic revolutions new fields of “omics” research are emerging. The metabolome provides the natural complement to the genome and proteome, however, the extreme physicochemical diversity of the metabolome leads to a subdivision of metabolites into compounds...

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Published in: Journal of Inherited Metabolic Disease
ISSN: 0141-8955 1573-2665
Published: 2011
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URI: https://cronfa.swan.ac.uk/Record/cronfa10761
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last_indexed 2018-08-17T13:54:43Z
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spelling 2018-08-17T10:37:49.0783207 v2 10761 2012-05-21 On the future of “omics”: lipidomics 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 2012-05-21 BMS Following in the wake of the genomic and proteomic revolutions new fields of “omics” research are emerging. The metabolome provides the natural complement to the genome and proteome, however, the extreme physicochemical diversity of the metabolome leads to a subdivision of metabolites into compounds soluble in aqueous solutions or those soluble in organic solvents. A complete molecular and quantitative investigation of the latter when isolated from tissue, fluid or cells constitutes lipidomics. Like proteomics, lipidomics is a subject which is both technology driven and technology driving, with the primary technologies being mass spectrometry, with or without on-line chromatography and computer-assisted data analysis. In this paper we will examine the underlying fundamentals of different lipidomic experimental approaches including the “shotgun” and “top-down” global approaches, and the more targeted liquid chromatography – or gas chromatography – mass spectrometry approaches. Application of these approaches to the identification of in-born errors of metabolism will be discussed. Journal Article Journal of Inherited Metabolic Disease 34 3 583 592 0141-8955 1573-2665 30 6 2011 2011-06-30 10.1007/s10545-010-9274-4 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2018-08-17T10:37:49.0783207 2012-05-21T15:45:17.7837425 Swansea University Medical School Medicine William Griffiths 0000-0002-4129-6616 1 Michael Ogundare 2 Christopher M. Williams 3 Yuqin Wang 0000-0002-3063-3066 4
title On the future of “omics”: lipidomics
spellingShingle On the future of “omics”: lipidomics
William, Griffiths
Yuqin, Wang
title_short On the future of “omics”: lipidomics
title_full On the future of “omics”: lipidomics
title_fullStr On the future of “omics”: lipidomics
title_full_unstemmed On the future of “omics”: lipidomics
title_sort On the future of “omics”: lipidomics
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
c92729b58622f9fdf6a0e7d8f4ce5081
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William, Griffiths
c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin, Wang
author William, Griffiths
Yuqin, Wang
format Journal article
container_title Journal of Inherited Metabolic Disease
container_volume 34
container_issue 3
container_start_page 583
publishDate 2011
institution Swansea University
issn 0141-8955
1573-2665
doi_str_mv 10.1007/s10545-010-9274-4
college_str Swansea University Medical School
hierarchytype
hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
document_store_str 0
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description Following in the wake of the genomic and proteomic revolutions new fields of “omics” research are emerging. The metabolome provides the natural complement to the genome and proteome, however, the extreme physicochemical diversity of the metabolome leads to a subdivision of metabolites into compounds soluble in aqueous solutions or those soluble in organic solvents. A complete molecular and quantitative investigation of the latter when isolated from tissue, fluid or cells constitutes lipidomics. Like proteomics, lipidomics is a subject which is both technology driven and technology driving, with the primary technologies being mass spectrometry, with or without on-line chromatography and computer-assisted data analysis. In this paper we will examine the underlying fundamentals of different lipidomic experimental approaches including the “shotgun” and “top-down” global approaches, and the more targeted liquid chromatography – or gas chromatography – mass spectrometry approaches. Application of these approaches to the identification of in-born errors of metabolism will be discussed.
published_date 2011-06-30T03:23:09Z
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