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Development and application of novel analytical methods in lipidomics / William, Griffiths

Chemical Genomics and Proteomics, Second Edition

Swansea University Author: William, Griffiths

Abstract

Lipidomics can be regarded as the determination of the quantitative lipid profile of a cell type, tissue or biological fluid. Mass spectrometry has become the dominant analytical technique in lipidomics. Here we will discuss the developments in mass spectrometry-based lipidomics, highlighting method...

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Published in: Chemical Genomics and Proteomics, Second Edition
Published: Taylor & Francis Group 2012
URI: https://cronfa.swan.ac.uk/Record/cronfa10814
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Abstract: Lipidomics can be regarded as the determination of the quantitative lipid profile of a cell type, tissue or biological fluid. Mass spectrometry has become the dominant analytical technique in lipidomics. Here we will discuss the developments in mass spectrometry-based lipidomics, highlighting methods based on shotgun-lipidomics, gas-chromatography - mass spectrometry and liquid-chromatography – tandem mass spectrometry. Examples will be given from the current literature and the authors own work. The importance of suitable sample preparation methods will also be emphasised.
College: Swansea University Medical School