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No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data. / Sinead Brophy

Semin Arthritis Rheum., Volume: 42, Issue: 2, Pages: 140 - 5

Swansea University Author: Sinead, Brophy

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DOI (Published version): 10.1016/j.semarthrit.2012.02.008

Abstract

OBJECTIVES: To examine if people with ankylosing spondylitis (AS) are at higher risk of acute myocardial infarction (MI) or stroke compared to those without AS.METHODS: Primary care records were linked with all hospital admissions and deaths caused by MI or stroke in Wales for the years 1999-2010. T...

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Published in: Semin Arthritis Rheum.
Published: 2012
URI: https://cronfa.swan.ac.uk/Record/cronfa11713
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2013-09-26T15:41:13.0255117</datestamp><bib-version>v2</bib-version><id>11713</id><entry>2012-06-19</entry><title>No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data.</title><swanseaauthors><author><sid>84f5661b35a729f55047f9e793d8798b</sid><ORCID>0000-0001-7417-2858</ORCID><firstname>Sinead</firstname><surname>Brophy</surname><name>Sinead Brophy</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2012-06-19</date><deptcode>BMS</deptcode><abstract>OBJECTIVES: To examine if people with ankylosing spondylitis (AS) are at higher risk of acute myocardial infarction (MI) or stroke compared to those without AS.METHODS: Primary care records were linked with all hospital admissions and deaths caused by MI or stroke in Wales for the years 1999-2010. The linked data were then stratified by AS diagnosis and survival analysis was used to obtain the incidence rate of MI and separately cerebrovascular disease (CVD)/stroke. Cox regression was used to adjust for gender and age. Logistic regression was used to examine prevalence of diabetes, hypertension, or hyperlipidemia for those with AS compared to those without.RESULTS: There were 1686 AS patients (75.9% male, average age 46.1 years) compared to 1,206,621 controls (48.9% male, average age 35.9 years). Age- and gender-adjusted hazard ratios for MI were 1.28 (95% CI: 0.93 to 1.74) P = 0.12, and for CVD/stroke 1.0 (95% CI: 0.73 to 1.39) P = 0.9, in AS compared to controls. The prevalence of diabetes and hypertension, but not hyperlipidemia/hypercholesterolemia, was higher in AS.CONCLUSIONS: There is no increase in the MI or CVD/stroke rates in patients with AS compared to those without AS, despite higher rates of hypertension, which may be related to nonsteroidal anti-inflammatory drug use.</abstract><type>Journal Article</type><journal>Semin Arthritis Rheum.</journal><volume>42</volume><journalNumber>2</journalNumber><paginationStart>140</paginationStart><paginationEnd>5</paginationEnd><publisher/><placeOfPublication/><issnPrint/><issnElectronic/><keywords/><publishedDay>31</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2012</publishedYear><publishedDate>2012-10-31</publishedDate><doi>10.1016/j.semarthrit.2012.02.008</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><lastEdited>2013-09-26T15:41:13.0255117</lastEdited><Created>2012-06-19T11:35:58.5446359</Created><path><level id="1">Swansea University Medical School</level><level id="2">Medicine</level></path><authors><author><firstname>Sinead</firstname><surname>Brophy</surname><orcid>0000-0001-7417-2858</orcid><order>1</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2013-09-26T15:41:13.0255117 v2 11713 2012-06-19 No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data. 84f5661b35a729f55047f9e793d8798b 0000-0001-7417-2858 Sinead Brophy Sinead Brophy true false 2012-06-19 BMS OBJECTIVES: To examine if people with ankylosing spondylitis (AS) are at higher risk of acute myocardial infarction (MI) or stroke compared to those without AS.METHODS: Primary care records were linked with all hospital admissions and deaths caused by MI or stroke in Wales for the years 1999-2010. The linked data were then stratified by AS diagnosis and survival analysis was used to obtain the incidence rate of MI and separately cerebrovascular disease (CVD)/stroke. Cox regression was used to adjust for gender and age. Logistic regression was used to examine prevalence of diabetes, hypertension, or hyperlipidemia for those with AS compared to those without.RESULTS: There were 1686 AS patients (75.9% male, average age 46.1 years) compared to 1,206,621 controls (48.9% male, average age 35.9 years). Age- and gender-adjusted hazard ratios for MI were 1.28 (95% CI: 0.93 to 1.74) P = 0.12, and for CVD/stroke 1.0 (95% CI: 0.73 to 1.39) P = 0.9, in AS compared to controls. The prevalence of diabetes and hypertension, but not hyperlipidemia/hypercholesterolemia, was higher in AS.CONCLUSIONS: There is no increase in the MI or CVD/stroke rates in patients with AS compared to those without AS, despite higher rates of hypertension, which may be related to nonsteroidal anti-inflammatory drug use. Journal Article Semin Arthritis Rheum. 42 2 140 5 31 10 2012 2012-10-31 10.1016/j.semarthrit.2012.02.008 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2013-09-26T15:41:13.0255117 2012-06-19T11:35:58.5446359 Swansea University Medical School Medicine Sinead Brophy 0000-0001-7417-2858 1
title No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data.
spellingShingle No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data.
Sinead, Brophy
title_short No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data.
title_full No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data.
title_fullStr No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data.
title_full_unstemmed No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data.
title_sort No Increased Rate of Acute Myocardial Infarction or Stroke Among Patients with Ankylosing Spondylitis-A Retrospective Cohort Study Using Routine Data.
author_id_str_mv 84f5661b35a729f55047f9e793d8798b
author_id_fullname_str_mv 84f5661b35a729f55047f9e793d8798b_***_Sinead, Brophy
author Sinead, Brophy
author2 Sinead Brophy
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container_title Semin Arthritis Rheum.
container_volume 42
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container_start_page 140
publishDate 2012
institution Swansea University
doi_str_mv 10.1016/j.semarthrit.2012.02.008
college_str Swansea University Medical School
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hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
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description OBJECTIVES: To examine if people with ankylosing spondylitis (AS) are at higher risk of acute myocardial infarction (MI) or stroke compared to those without AS.METHODS: Primary care records were linked with all hospital admissions and deaths caused by MI or stroke in Wales for the years 1999-2010. The linked data were then stratified by AS diagnosis and survival analysis was used to obtain the incidence rate of MI and separately cerebrovascular disease (CVD)/stroke. Cox regression was used to adjust for gender and age. Logistic regression was used to examine prevalence of diabetes, hypertension, or hyperlipidemia for those with AS compared to those without.RESULTS: There were 1686 AS patients (75.9% male, average age 46.1 years) compared to 1,206,621 controls (48.9% male, average age 35.9 years). Age- and gender-adjusted hazard ratios for MI were 1.28 (95% CI: 0.93 to 1.74) P = 0.12, and for CVD/stroke 1.0 (95% CI: 0.73 to 1.39) P = 0.9, in AS compared to controls. The prevalence of diabetes and hypertension, but not hyperlipidemia/hypercholesterolemia, was higher in AS.CONCLUSIONS: There is no increase in the MI or CVD/stroke rates in patients with AS compared to those without AS, despite higher rates of hypertension, which may be related to nonsteroidal anti-inflammatory drug use.
published_date 2012-10-31T03:22:11Z
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