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Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep

M A Hyatt, D H Keisler, H Budge, M E Symonds, Melanie Healy

Journal of Endocrinology, Volume: 204, Issue: 2, Pages: 173 - 179

Swansea University Author: Melanie Healy

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DOI (Published version): 10.1677/JOE-09-0358

Abstract

Maternal parity influences size at birth, postnatal growth and body composition with firstborn infants being more likely to be smaller with increased fat mass, suggesting that adiposity is set in early life. The precise effect of parity on fat mass and its endocrine sensitivity remains unclear and w...

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Published in: Journal of Endocrinology
ISSN: 0022-0795 1479-6805
Published: 2009
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URI: https://cronfa.swan.ac.uk/Record/cronfa12191
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spelling 2011-10-01T00:00:00.0000000 v2 12191 2012-07-20 Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep 4654b4128fb21d68f98e2abc8538b45a Melanie Healy Melanie Healy true false 2012-07-20 MEDS Maternal parity influences size at birth, postnatal growth and body composition with firstborn infants being more likely to be smaller with increased fat mass, suggesting that adiposity is set in early life. The precise effect of parity on fat mass and its endocrine sensitivity remains unclear and was, therefore, investigated in the present study. We utilised an established sheep model in which perirenal-abdominal fat mass (the major fat depot in the neonatal sheep) increases approximately 10-fold over the first month of life and focussed on the impact of parity on glucocorticoid sensitivity and adipokine expression in the adipocyte. Twin-bearing sheep of similar body weight and adiposity that consumed identical diets were utilised, and maternal blood samples were taken at 130 days of gestation. One offspring from each twin pair was sampled at 1 day of age, coincident with the time of maximal recruitment of uncoupling protein 1 (UCP1), whilst its sibling was sampled at 1 month, when UCP1 had disappeared. Plasma leptin was lower in nulliparous mothers than in multiparous mothers, and offspring of nulliparous mothers possessed more adipose tissue with increased mRNA abundance of leptin, glucocorticoid receptor and UCP2, adaptations that persisted up to 1 month of age when gene expression for interleukin-6 and adiponectin was also raised. The increase in fat mass associated with firstborn status is therefore accompanied by a resetting of the leptin and glucocorticoid axis within the adipocyte. Our findings emphasise the importance of parity in determining adipose tissue development and that firstborn offspring have an increased capacity for adipogenesis which may be critical in determining later adiposity. Journal Article Journal of Endocrinology 204 2 173 179 0022-0795 1479-6805 30 11 2009 2009-11-30 10.1677/JOE-09-0358 http://joe.endocrinology-journals.org/content/204/2/173.long COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2011-10-01T00:00:00.0000000 2012-07-20T11:37:34.2677274 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine M A Hyatt 1 D H Keisler 2 H Budge 3 M E Symonds 4 Melanie Healy 5
title Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
spellingShingle Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
Melanie Healy
title_short Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
title_full Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
title_fullStr Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
title_full_unstemmed Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
title_sort Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
author_id_str_mv 4654b4128fb21d68f98e2abc8538b45a
author_id_fullname_str_mv 4654b4128fb21d68f98e2abc8538b45a_***_Melanie Healy
author Melanie Healy
author2 M A Hyatt
D H Keisler
H Budge
M E Symonds
Melanie Healy
format Journal article
container_title Journal of Endocrinology
container_volume 204
container_issue 2
container_start_page 173
publishDate 2009
institution Swansea University
issn 0022-0795
1479-6805
doi_str_mv 10.1677/JOE-09-0358
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://joe.endocrinology-journals.org/content/204/2/173.long
document_store_str 0
active_str 0
description Maternal parity influences size at birth, postnatal growth and body composition with firstborn infants being more likely to be smaller with increased fat mass, suggesting that adiposity is set in early life. The precise effect of parity on fat mass and its endocrine sensitivity remains unclear and was, therefore, investigated in the present study. We utilised an established sheep model in which perirenal-abdominal fat mass (the major fat depot in the neonatal sheep) increases approximately 10-fold over the first month of life and focussed on the impact of parity on glucocorticoid sensitivity and adipokine expression in the adipocyte. Twin-bearing sheep of similar body weight and adiposity that consumed identical diets were utilised, and maternal blood samples were taken at 130 days of gestation. One offspring from each twin pair was sampled at 1 day of age, coincident with the time of maximal recruitment of uncoupling protein 1 (UCP1), whilst its sibling was sampled at 1 month, when UCP1 had disappeared. Plasma leptin was lower in nulliparous mothers than in multiparous mothers, and offspring of nulliparous mothers possessed more adipose tissue with increased mRNA abundance of leptin, glucocorticoid receptor and UCP2, adaptations that persisted up to 1 month of age when gene expression for interleukin-6 and adiponectin was also raised. The increase in fat mass associated with firstborn status is therefore accompanied by a resetting of the leptin and glucocorticoid axis within the adipocyte. Our findings emphasise the importance of parity in determining adipose tissue development and that firstborn offspring have an increased capacity for adipogenesis which may be critical in determining later adiposity.
published_date 2009-11-30T18:23:12Z
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