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Early developmental influences on hepatic organogenesis

Melanie A Hyatt, Helen Budge, Michael E Symonds, Melanie Healy

Organogenesis, Volume: 4, Issue: 3, Pages: 170 - 175

Swansea University Author: Melanie Healy

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DOI (Published version): 10.4161/org.4.3.6849

Abstract

The liver is the largest of the body's organs, with the greatest number of functions, playing a central role in coordinating metabolic homeostasis, nutrient processing and detoxification. The fetal liver forms during early gestation in response to a sequential array of distinct biological event...

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Published in: Organogenesis
ISSN: 1547-6278
Published: 2008
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URI: https://cronfa.swan.ac.uk/Record/cronfa12195
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first_indexed 2013-07-23T12:07:34Z
last_indexed 2018-02-09T04:42:13Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2011-10-01T00:00:00.0000000</datestamp><bib-version>v2</bib-version><id>12195</id><entry>2012-07-20</entry><title>Early developmental influences on hepatic organogenesis</title><swanseaauthors><author><sid>4654b4128fb21d68f98e2abc8538b45a</sid><firstname>Melanie</firstname><surname>Healy</surname><name>Melanie Healy</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2012-07-20</date><deptcode>PHAR</deptcode><abstract>The liver is the largest of the body's organs, with the greatest number of functions, playing a central role in coordinating metabolic homeostasis, nutrient processing and detoxification. The fetal liver forms during early gestation in response to a sequential array of distinct biological events, regulated by intrinsically programmed mechanisms and extracellular signals which instruct hepatic cells to either proliferate, differentiate or undergo apoptosis. A vast number of genes are involved in the initiation and control of liver development, many of which are sensitive to nutritional and hormonal regulation in utero. Moreover, liver mass is influenced by the gestational environment. Therefore, during periods of hepatic cell proliferation and differentiation, the developing fetal liver is sensitive to damage from both internal and external sources including teratogens, infection and nutritional deficiencies. For example, fetuses exposed to decreased materno-fetal nutrition during late gestation have a reduced liver mass, and/or perturbed liver function, which includes increased plasma LDL cholesterol and fibrinogen concentrations. These occur in conjunction with other risk factors present in the early stages of cardiovascular disease i.e. decreased glucose tolerance and insulin insensitivity in later life. Taken together, these findings suggest that liver mass, and later function, are essentially set in utero during fetal development&#x2014;a process that is ultimately regulated by the intrauterine environment.</abstract><type>Journal Article</type><journal>Organogenesis</journal><volume>4</volume><journalNumber>3</journalNumber><paginationStart>170</paginationStart><paginationEnd>175</paginationEnd><publisher/><placeOfPublication/><issnPrint>1547-6278</issnPrint><issnElectronic/><keywords/><publishedDay>30</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2008</publishedYear><publishedDate>2008-09-30</publishedDate><doi>10.4161/org.4.3.6849</doi><url>http://www.landesbioscience.com/journals/9/article/6849/</url><notes/><college>COLLEGE NANME</college><department>Pharmacy</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PHAR</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2011-10-01T00:00:00.0000000</lastEdited><Created>2012-07-20T11:47:04.1519148</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Melanie A</firstname><surname>Hyatt</surname><order>1</order></author><author><firstname>Helen</firstname><surname>Budge</surname><order>2</order></author><author><firstname>Michael E</firstname><surname>Symonds</surname><order>3</order></author><author><firstname>Melanie</firstname><surname>Healy</surname><order>4</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2011-10-01T00:00:00.0000000 v2 12195 2012-07-20 Early developmental influences on hepatic organogenesis 4654b4128fb21d68f98e2abc8538b45a Melanie Healy Melanie Healy true false 2012-07-20 PHAR The liver is the largest of the body's organs, with the greatest number of functions, playing a central role in coordinating metabolic homeostasis, nutrient processing and detoxification. The fetal liver forms during early gestation in response to a sequential array of distinct biological events, regulated by intrinsically programmed mechanisms and extracellular signals which instruct hepatic cells to either proliferate, differentiate or undergo apoptosis. A vast number of genes are involved in the initiation and control of liver development, many of which are sensitive to nutritional and hormonal regulation in utero. Moreover, liver mass is influenced by the gestational environment. Therefore, during periods of hepatic cell proliferation and differentiation, the developing fetal liver is sensitive to damage from both internal and external sources including teratogens, infection and nutritional deficiencies. For example, fetuses exposed to decreased materno-fetal nutrition during late gestation have a reduced liver mass, and/or perturbed liver function, which includes increased plasma LDL cholesterol and fibrinogen concentrations. These occur in conjunction with other risk factors present in the early stages of cardiovascular disease i.e. decreased glucose tolerance and insulin insensitivity in later life. Taken together, these findings suggest that liver mass, and later function, are essentially set in utero during fetal development—a process that is ultimately regulated by the intrauterine environment. Journal Article Organogenesis 4 3 170 175 1547-6278 30 9 2008 2008-09-30 10.4161/org.4.3.6849 http://www.landesbioscience.com/journals/9/article/6849/ COLLEGE NANME Pharmacy COLLEGE CODE PHAR Swansea University 2011-10-01T00:00:00.0000000 2012-07-20T11:47:04.1519148 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Melanie A Hyatt 1 Helen Budge 2 Michael E Symonds 3 Melanie Healy 4
title Early developmental influences on hepatic organogenesis
spellingShingle Early developmental influences on hepatic organogenesis
Melanie Healy
title_short Early developmental influences on hepatic organogenesis
title_full Early developmental influences on hepatic organogenesis
title_fullStr Early developmental influences on hepatic organogenesis
title_full_unstemmed Early developmental influences on hepatic organogenesis
title_sort Early developmental influences on hepatic organogenesis
author_id_str_mv 4654b4128fb21d68f98e2abc8538b45a
author_id_fullname_str_mv 4654b4128fb21d68f98e2abc8538b45a_***_Melanie Healy
author Melanie Healy
author2 Melanie A Hyatt
Helen Budge
Michael E Symonds
Melanie Healy
format Journal article
container_title Organogenesis
container_volume 4
container_issue 3
container_start_page 170
publishDate 2008
institution Swansea University
issn 1547-6278
doi_str_mv 10.4161/org.4.3.6849
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.landesbioscience.com/journals/9/article/6849/
document_store_str 0
active_str 0
description The liver is the largest of the body's organs, with the greatest number of functions, playing a central role in coordinating metabolic homeostasis, nutrient processing and detoxification. The fetal liver forms during early gestation in response to a sequential array of distinct biological events, regulated by intrinsically programmed mechanisms and extracellular signals which instruct hepatic cells to either proliferate, differentiate or undergo apoptosis. A vast number of genes are involved in the initiation and control of liver development, many of which are sensitive to nutritional and hormonal regulation in utero. Moreover, liver mass is influenced by the gestational environment. Therefore, during periods of hepatic cell proliferation and differentiation, the developing fetal liver is sensitive to damage from both internal and external sources including teratogens, infection and nutritional deficiencies. For example, fetuses exposed to decreased materno-fetal nutrition during late gestation have a reduced liver mass, and/or perturbed liver function, which includes increased plasma LDL cholesterol and fibrinogen concentrations. These occur in conjunction with other risk factors present in the early stages of cardiovascular disease i.e. decreased glucose tolerance and insulin insensitivity in later life. Taken together, these findings suggest that liver mass, and later function, are essentially set in utero during fetal development—a process that is ultimately regulated by the intrauterine environment.
published_date 2008-09-30T03:14:06Z
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score 10.998093

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