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The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults / M. A McNarry, M. I. C Kingsley, M. J Lewis, Michael Lewis, Melitta McNarry

AJP: Regulatory, Integrative and Comparative Physiology

Swansea University Authors: Michael Lewis, Melitta McNarry

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Abstract

It is unclear whether pulmonary oxygen uptake (VO2) kinetics demonstrate linear, first order behaviour during supra gas exchange threshold exercise. Resolution of this issue is pertinent to the elucidation of the factors regulating VO2 kinetics, with oxygen availability and utilisation proposed as p...

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Published in: AJP: Regulatory, Integrative and Comparative Physiology
ISSN: 0363-6119 1522-1490
Published: 2012
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URI: https://cronfa.swan.ac.uk/Record/cronfa12784
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2017-11-25T09:47:49.6324003</datestamp><bib-version>v2</bib-version><id>12784</id><entry>2012-09-24</entry><title>The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults</title><swanseaauthors><author><sid>b59c8f5c056bac7e6995385f22ad1639</sid><firstname>Michael</firstname><surname>Lewis</surname><name>Michael Lewis</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>062f5697ff59f004bc8c713955988398</sid><ORCID>0000-0003-0813-7477</ORCID><firstname>Melitta</firstname><surname>McNarry</surname><name>Melitta McNarry</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2012-09-24</date><deptcode>EEN</deptcode><abstract>It is unclear whether pulmonary oxygen uptake (VO2) kinetics demonstrate linear, first order behaviour during supra gas exchange threshold exercise. Resolution of this issue is pertinent to the elucidation of the factors regulating VO2 kinetics, with oxygen availability and utilisation proposed as putative mediators. To re-examine this issue with the advantage of a relatively large sample size, fifty young (24&#xB1;4 yrs) and fifteen late middle-aged (54&#xB1;3 yrs) participants completed repeated bouts of moderate and heavy exercise. Pulmonary gas exchange, heart rate (HR) and cardiac output ("Q") variables were measured throughout. The phase II &#x3C4; was slower during heavy exercise in both young (Mod: 22&#xB1;9; Hvy: 29&#xB1;9s; P&#x2264;0.001) and middle-aged (Mod: 22&#xB1;9; Hvy: 30&#xB1;8s; P&#x2264;0.001) individuals. The HR &#x3C4; was slower during heavy exercise in young (Mod: 33&#xB1;10; Hvy: 44&#xB1;15s; P&#x2264;0.05) and middle-aged (Mod: 30&#xB1;12; Hvy: 50&#xB1;20s; P&#x2264;0.05) participants, and the "Q" &#x3C4; showed a similar trend (Young - Mod: 21&#xB1;13; Hvy: 28&#xB1;16 s; Middle-aged - Mod: 32&#xB1;13; Hvy: 40&#xB1;15s; P&#x2265;0.05). There were no differences in primary component VO2 kinetics between age groups but the middle-aged group had a significantly reduced VO2 slow component amplitude in both absolute (Young: 0.25&#xB1;0.09; Middle-aged: 0.11&#xB1;0.06 l&#x2219;min-1; P&#x2264;0.05) and relative terms (Young: 15&#xB1;10; Middle-aged: 9&#xB1;4%; P&#x2264;0.05). Thus, VO2 kinetics do not demonstrate dynamic linearity during heavy intensity exercise. Speculatively, the slower phase II &#x3C4; during heavy exercise might be attributable to reduced oxygen availability. Finally, the primary and slow components of VO2 kinetics appear to be differentially influenced by middle-age.</abstract><type>Journal Article</type><journal>AJP: Regulatory, Integrative and Comparative Physiology</journal><publisher/><issnPrint>0363-6119</issnPrint><issnElectronic>1522-1490</issnElectronic><keywords/><publishedDay>15</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2012</publishedYear><publishedDate>2012-10-15</publishedDate><doi>10.1152/ajpregu.00203.2012</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EEN</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2017-11-25T09:47:49.6324003</lastEdited><Created>2012-09-24T11:06:21.8515700</Created><path><level id="1">College of Engineering</level><level id="2">Engineering</level></path><authors><author><firstname>M. A</firstname><surname>McNarry</surname><order>1</order></author><author><firstname>M. I. C</firstname><surname>Kingsley</surname><order>2</order></author><author><firstname>M. J</firstname><surname>Lewis</surname><order>3</order></author><author><firstname>Michael</firstname><surname>Lewis</surname><order>4</order></author><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>5</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2017-11-25T09:47:49.6324003 v2 12784 2012-09-24 The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults b59c8f5c056bac7e6995385f22ad1639 Michael Lewis Michael Lewis true false 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 2012-09-24 EEN It is unclear whether pulmonary oxygen uptake (VO2) kinetics demonstrate linear, first order behaviour during supra gas exchange threshold exercise. Resolution of this issue is pertinent to the elucidation of the factors regulating VO2 kinetics, with oxygen availability and utilisation proposed as putative mediators. To re-examine this issue with the advantage of a relatively large sample size, fifty young (24±4 yrs) and fifteen late middle-aged (54±3 yrs) participants completed repeated bouts of moderate and heavy exercise. Pulmonary gas exchange, heart rate (HR) and cardiac output ("Q") variables were measured throughout. The phase II τ was slower during heavy exercise in both young (Mod: 22±9; Hvy: 29±9s; P≤0.001) and middle-aged (Mod: 22±9; Hvy: 30±8s; P≤0.001) individuals. The HR τ was slower during heavy exercise in young (Mod: 33±10; Hvy: 44±15s; P≤0.05) and middle-aged (Mod: 30±12; Hvy: 50±20s; P≤0.05) participants, and the "Q" τ showed a similar trend (Young - Mod: 21±13; Hvy: 28±16 s; Middle-aged - Mod: 32±13; Hvy: 40±15s; P≥0.05). There were no differences in primary component VO2 kinetics between age groups but the middle-aged group had a significantly reduced VO2 slow component amplitude in both absolute (Young: 0.25±0.09; Middle-aged: 0.11±0.06 l∙min-1; P≤0.05) and relative terms (Young: 15±10; Middle-aged: 9±4%; P≤0.05). Thus, VO2 kinetics do not demonstrate dynamic linearity during heavy intensity exercise. Speculatively, the slower phase II τ during heavy exercise might be attributable to reduced oxygen availability. Finally, the primary and slow components of VO2 kinetics appear to be differentially influenced by middle-age. Journal Article AJP: Regulatory, Integrative and Comparative Physiology 0363-6119 1522-1490 15 10 2012 2012-10-15 10.1152/ajpregu.00203.2012 COLLEGE NANME Engineering COLLEGE CODE EEN Swansea University 2017-11-25T09:47:49.6324003 2012-09-24T11:06:21.8515700 College of Engineering Engineering M. A McNarry 1 M. I. C Kingsley 2 M. J Lewis 3 Michael Lewis 4 Melitta McNarry 0000-0003-0813-7477 5
title The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
spellingShingle The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
Michael, Lewis
Melitta, McNarry
title_short The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
title_full The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
title_fullStr The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
title_full_unstemmed The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
title_sort The influence of exercise intensity on pulmonary oxygen uptake kinetics in young and late middle-aged adults
author_id_str_mv b59c8f5c056bac7e6995385f22ad1639
062f5697ff59f004bc8c713955988398
author_id_fullname_str_mv b59c8f5c056bac7e6995385f22ad1639_***_Michael, Lewis
062f5697ff59f004bc8c713955988398_***_Melitta, McNarry
author Michael, Lewis
Melitta, McNarry
author2 M. A McNarry
M. I. C Kingsley
M. J Lewis
Michael Lewis
Melitta McNarry
format Journal article
container_title AJP: Regulatory, Integrative and Comparative Physiology
publishDate 2012
institution Swansea University
issn 0363-6119
1522-1490
doi_str_mv 10.1152/ajpregu.00203.2012
college_str College of Engineering
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hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
document_store_str 0
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description It is unclear whether pulmonary oxygen uptake (VO2) kinetics demonstrate linear, first order behaviour during supra gas exchange threshold exercise. Resolution of this issue is pertinent to the elucidation of the factors regulating VO2 kinetics, with oxygen availability and utilisation proposed as putative mediators. To re-examine this issue with the advantage of a relatively large sample size, fifty young (24±4 yrs) and fifteen late middle-aged (54±3 yrs) participants completed repeated bouts of moderate and heavy exercise. Pulmonary gas exchange, heart rate (HR) and cardiac output ("Q") variables were measured throughout. The phase II τ was slower during heavy exercise in both young (Mod: 22±9; Hvy: 29±9s; P≤0.001) and middle-aged (Mod: 22±9; Hvy: 30±8s; P≤0.001) individuals. The HR τ was slower during heavy exercise in young (Mod: 33±10; Hvy: 44±15s; P≤0.05) and middle-aged (Mod: 30±12; Hvy: 50±20s; P≤0.05) participants, and the "Q" τ showed a similar trend (Young - Mod: 21±13; Hvy: 28±16 s; Middle-aged - Mod: 32±13; Hvy: 40±15s; P≥0.05). There were no differences in primary component VO2 kinetics between age groups but the middle-aged group had a significantly reduced VO2 slow component amplitude in both absolute (Young: 0.25±0.09; Middle-aged: 0.11±0.06 l∙min-1; P≤0.05) and relative terms (Young: 15±10; Middle-aged: 9±4%; P≤0.05). Thus, VO2 kinetics do not demonstrate dynamic linearity during heavy intensity exercise. Speculatively, the slower phase II τ during heavy exercise might be attributable to reduced oxygen availability. Finally, the primary and slow components of VO2 kinetics appear to be differentially influenced by middle-age.
published_date 2012-10-15T03:23:22Z
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