Staphylococcus epidermidis in Biomaterial-Associated Infections

Davies, Angharad; Mack, Dietrich; Davies, Angharad P; Harris, Llinos G; Jeeves, Rose; Pascoe, Ben; Knobloch, Johannes K.-M; Rohde, Holger; Wilkinson, Thomas S

doi:10.1007/978-1-4614-1031-7_2

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Staphylococcus epidermidis in Biomaterial-Associated Infections

Angharad Davies

, Dietrich Mack, Angharad P Davies, Llinos G Harris, Rose Jeeves, Ben Pascoe

, Johannes K.-M Knobloch, Holger Rohde, Thomas S Wilkinson

Biomaterials Associated Infection, Pages: 25 - 56

Swansea University Authors: Angharad Davies , Ben Pascoe

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DOI (Published version): 10.1007/978-1-4614-1031-7_2

Abstract

Coagulase-negative staphylococci, mainly Staphylococcus epidermidis, are currently the most frequent cause of hospital acquired infections in the USA. Mostly, but not exclusively, S. epidermidis infections are linked to the use of implanted medical devices like central venous catheters, prosthetic j...

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Published in:	Biomaterials Associated Infection
Published:	Springer 2012
URI:	https://cronfa.swan.ac.uk/Record/cronfa13121
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first_indexed	2013-07-23T12:09:31Z
last_indexed	2018-02-09T04:43:40Z
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spelling	2011-10-01T00:00:00.0000000 v2 13121 2012-10-23 Staphylococcus epidermidis in Biomaterial-Associated Infections 62586459693e05b2e1063967e76883f1 0000-0003-4190-8894 Angharad Davies Angharad Davies true false 4660c0eb7e6bfd796cd749ae713ea558 0000-0001-6376-5121 Ben Pascoe Ben Pascoe true false 2012-10-23 PMSC Coagulase-negative staphylococci, mainly Staphylococcus epidermidis, are currently the most frequent cause of hospital acquired infections in the USA. Mostly, but not exclusively, S. epidermidis infections are linked to the use of implanted medical devices like central venous catheters, prosthetic joints and heart valves, pacemakers, cardiac assist devices, cerebrospinal fluid shunts, and intraocular lenses. As new molecular techniques reveal that S. epidermidis are by no means the most prominent bacteria of the skin and mucous membrane flora, the implication is that S. epidermidis has specific virulence factors, which transforms this commensal bacterial species into one of the most successful pathogens in modern medicine. A vast array of specific attachment factors for native and host protein-modified device surfaces and the ability to accumulate in adherent multilayered biofilms appear to be vital for the success of S. epidermidis as a pathogen. Biofilm formation contributes to the ability of the organism to withstand the host’s innate and acquired immune defense mechanisms and to resist antimicrobial therapy, so that device removal is a regular feature for the treatment of S. epidermidis biomaterial-associated infection. Recent developments in the understanding of S. epidermidis virulence are reviewed in this chapter. Book chapter Biomaterials Associated Infection 25 56 Springer 29 9 2012 2012-09-29 10.1007/978-1-4614-1031-7_2 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2011-10-01T00:00:00.0000000 2012-10-23T12:50:34.8685509 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Angharad Davies 0000-0003-4190-8894 1 Dietrich Mack 2 Angharad P Davies 3 Llinos G Harris 4 Rose Jeeves 5 Ben Pascoe 0000-0001-6376-5121 6 Johannes K.-M Knobloch 7 Holger Rohde 8 Thomas S Wilkinson 9
title	Staphylococcus epidermidis in Biomaterial-Associated Infections
spellingShingle	Staphylococcus epidermidis in Biomaterial-Associated Infections Angharad Davies Ben Pascoe
title_short	Staphylococcus epidermidis in Biomaterial-Associated Infections
title_full	Staphylococcus epidermidis in Biomaterial-Associated Infections
title_fullStr	Staphylococcus epidermidis in Biomaterial-Associated Infections
title_full_unstemmed	Staphylococcus epidermidis in Biomaterial-Associated Infections
title_sort	Staphylococcus epidermidis in Biomaterial-Associated Infections
author_id_str_mv	62586459693e05b2e1063967e76883f1 4660c0eb7e6bfd796cd749ae713ea558
author_id_fullname_str_mv	62586459693e05b2e1063967e76883f1_*_Angharad Davies 4660c0eb7e6bfd796cd749ae713ea558_*_Ben Pascoe
author	Angharad Davies Ben Pascoe
author2	Angharad Davies Dietrich Mack Angharad P Davies Llinos G Harris Rose Jeeves Ben Pascoe Johannes K.-M Knobloch Holger Rohde Thomas S Wilkinson
format	Book chapter
container_title	Biomaterials Associated Infection
container_start_page	25
publishDate	2012
institution	Swansea University
doi_str_mv	10.1007/978-1-4614-1031-7_2
publisher	Springer
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description	Coagulase-negative staphylococci, mainly Staphylococcus epidermidis, are currently the most frequent cause of hospital acquired infections in the USA. Mostly, but not exclusively, S. epidermidis infections are linked to the use of implanted medical devices like central venous catheters, prosthetic joints and heart valves, pacemakers, cardiac assist devices, cerebrospinal fluid shunts, and intraocular lenses. As new molecular techniques reveal that S. epidermidis are by no means the most prominent bacteria of the skin and mucous membrane flora, the implication is that S. epidermidis has specific virulence factors, which transforms this commensal bacterial species into one of the most successful pathogens in modern medicine. A vast array of specific attachment factors for native and host protein-modified device surfaces and the ability to accumulate in adherent multilayered biofilms appear to be vital for the success of S. epidermidis as a pathogen. Biofilm formation contributes to the ability of the organism to withstand the host’s innate and acquired immune defense mechanisms and to resist antimicrobial therapy, so that device removal is a regular feature for the treatment of S. epidermidis biomaterial-associated infection. Recent developments in the understanding of S. epidermidis virulence are reviewed in this chapter.
published_date	2012-09-29T03:15:03Z
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Staphylococcus epidermidis in Biomaterial-Associated Infections

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