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Progressive genome-wide introgression in agricultural Campylobacter coli

Samuel Sheppard, Xavier Didelot, Keith A Jolley, Aaron E Darling, Ben Pascoe Orcid Logo, Guillaume Meric, David J Kelly, Alison Cody, Frances M Colles, Norval J. C Strachan, Iain D Ogden, Ken Forbes, Nigel P French, Philip Carter, William G Miller, Noel D McCarthy, Robert Owen, Eva Litrup, Michael Egholm, Jason P Affourtit, Stephen D Bentley, Julian Parkhill, Martin C. J Maiden, Daniel Falush

Molecular Ecology, Volume: 22, Issue: 3

Swansea University Authors: Samuel Sheppard, Ben Pascoe Orcid Logo, Guillaume Meric

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DOI (Published version): 10.1111/mec.12162

Abstract

Hybridization between distantly related organisms can facilitate rapid adaptation to novel environments, but is potentially constrained by epistatic fitness interactions among cell components. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleot...

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Published in: Molecular Ecology
ISSN: 0962-1083
Published: 2012
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URI: https://cronfa.swan.ac.uk/Record/cronfa13853
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The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleotide level, corresponding to an average of nearly 40 amino acids per protein-coding gene. Using whole genome sequencing, we show that a single C. coli lineage, which has successfully colonized an agricultural niche, has been progressively accumulating C. jejuni DNA. Members of this lineage belong to two groups, the ST-828 and ST-1150 clonal complexes. The ST-1150 complex is less frequently isolated and has undergone a substantially greater amount of introgression leading to replacement of up to 23% of the C. coli core genome as well as import of novel DNA. By contrast, the more commonly isolated ST-828 complex bacteria have 10&#x2013;11% introgressed DNA, and C. jejuni and nonagricultural C. coli lineages each have &lt;2%. Thus, the C. coli that colonize agriculture, and consequently cause most human disease, have hybrid origin, but this cross-species exchange has so far not had a substantial impact on the gene pools of either C. jejuni or nonagricultural C. coli. 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spelling 2011-10-01T00:00:00.0000000 v2 13853 2013-01-09 Progressive genome-wide introgression in agricultural Campylobacter coli 8842c14adb4a58a22fb2aeeedcdef60c Samuel Sheppard Samuel Sheppard true false 4660c0eb7e6bfd796cd749ae713ea558 0000-0001-6376-5121 Ben Pascoe Ben Pascoe true false 9384e450ee619395be7459d6bd7a8f6d Guillaume Meric Guillaume Meric true false 2013-01-09 PMSC Hybridization between distantly related organisms can facilitate rapid adaptation to novel environments, but is potentially constrained by epistatic fitness interactions among cell components. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleotide level, corresponding to an average of nearly 40 amino acids per protein-coding gene. Using whole genome sequencing, we show that a single C. coli lineage, which has successfully colonized an agricultural niche, has been progressively accumulating C. jejuni DNA. Members of this lineage belong to two groups, the ST-828 and ST-1150 clonal complexes. The ST-1150 complex is less frequently isolated and has undergone a substantially greater amount of introgression leading to replacement of up to 23% of the C. coli core genome as well as import of novel DNA. By contrast, the more commonly isolated ST-828 complex bacteria have 10–11% introgressed DNA, and C. jejuni and nonagricultural C. coli lineages each have <2%. Thus, the C. coli that colonize agriculture, and consequently cause most human disease, have hybrid origin, but this cross-species exchange has so far not had a substantial impact on the gene pools of either C. jejuni or nonagricultural C. coli. These findings also indicate remarkable interchangeability of basic cellular machinery after a prolonged period of independent evolution. Journal Article Molecular Ecology 22 3 0962-1083 adaptation; Campylobacter; epistasis; genomics; introgression 20 12 2012 2012-12-20 10.1111/mec.12162 http://onlinelibrary.wiley.com/doi/10.1111/mec.12162/abstract COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2011-10-01T00:00:00.0000000 2013-01-09T15:32:49.2289748 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Samuel Sheppard 1 Xavier Didelot 2 Keith A Jolley 3 Aaron E Darling 4 Ben Pascoe 0000-0001-6376-5121 5 Guillaume Meric 6 David J Kelly 7 Alison Cody 8 Frances M Colles 9 Norval J. C Strachan 10 Iain D Ogden 11 Ken Forbes 12 Nigel P French 13 Philip Carter 14 William G Miller 15 Noel D McCarthy 16 Robert Owen 17 Eva Litrup 18 Michael Egholm 19 Jason P Affourtit 20 Stephen D Bentley 21 Julian Parkhill 22 Martin C. J Maiden 23 Daniel Falush 24
title Progressive genome-wide introgression in agricultural Campylobacter coli
spellingShingle Progressive genome-wide introgression in agricultural Campylobacter coli
Samuel Sheppard
Ben Pascoe
Guillaume Meric
title_short Progressive genome-wide introgression in agricultural Campylobacter coli
title_full Progressive genome-wide introgression in agricultural Campylobacter coli
title_fullStr Progressive genome-wide introgression in agricultural Campylobacter coli
title_full_unstemmed Progressive genome-wide introgression in agricultural Campylobacter coli
title_sort Progressive genome-wide introgression in agricultural Campylobacter coli
author_id_str_mv 8842c14adb4a58a22fb2aeeedcdef60c
4660c0eb7e6bfd796cd749ae713ea558
9384e450ee619395be7459d6bd7a8f6d
author_id_fullname_str_mv 8842c14adb4a58a22fb2aeeedcdef60c_***_Samuel Sheppard
4660c0eb7e6bfd796cd749ae713ea558_***_Ben Pascoe
9384e450ee619395be7459d6bd7a8f6d_***_Guillaume Meric
author Samuel Sheppard
Ben Pascoe
Guillaume Meric
author2 Samuel Sheppard
Xavier Didelot
Keith A Jolley
Aaron E Darling
Ben Pascoe
Guillaume Meric
David J Kelly
Alison Cody
Frances M Colles
Norval J. C Strachan
Iain D Ogden
Ken Forbes
Nigel P French
Philip Carter
William G Miller
Noel D McCarthy
Robert Owen
Eva Litrup
Michael Egholm
Jason P Affourtit
Stephen D Bentley
Julian Parkhill
Martin C. J Maiden
Daniel Falush
format Journal article
container_title Molecular Ecology
container_volume 22
container_issue 3
publishDate 2012
institution Swansea University
issn 0962-1083
doi_str_mv 10.1111/mec.12162
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://onlinelibrary.wiley.com/doi/10.1111/mec.12162/abstract
document_store_str 0
active_str 0
description Hybridization between distantly related organisms can facilitate rapid adaptation to novel environments, but is potentially constrained by epistatic fitness interactions among cell components. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleotide level, corresponding to an average of nearly 40 amino acids per protein-coding gene. Using whole genome sequencing, we show that a single C. coli lineage, which has successfully colonized an agricultural niche, has been progressively accumulating C. jejuni DNA. Members of this lineage belong to two groups, the ST-828 and ST-1150 clonal complexes. The ST-1150 complex is less frequently isolated and has undergone a substantially greater amount of introgression leading to replacement of up to 23% of the C. coli core genome as well as import of novel DNA. By contrast, the more commonly isolated ST-828 complex bacteria have 10–11% introgressed DNA, and C. jejuni and nonagricultural C. coli lineages each have <2%. Thus, the C. coli that colonize agriculture, and consequently cause most human disease, have hybrid origin, but this cross-species exchange has so far not had a substantial impact on the gene pools of either C. jejuni or nonagricultural C. coli. These findings also indicate remarkable interchangeability of basic cellular machinery after a prolonged period of independent evolution.
published_date 2012-12-20T03:15:50Z
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