Journal article 3190 views
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
The Lancet, Volume: 380, Issue: 9859, Pages: 2163 - 2196
Swansea University Authors:
Belinda Gabbe , Ronan Lyons
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DOI (Published version): 10.1016/S0140-6736(12)61729-2
Abstract
Background Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion andmonitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and2000 have been the only studies to quantify non-fatal health outcomes across an e...
Published in: | The Lancet |
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ISSN: | 0140-6736 |
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2012
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URI: | https://cronfa.swan.ac.uk/Record/cronfa13938 |
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<?xml version="1.0"?><rfc1807><datestamp>2015-12-08T11:03:39.4018291</datestamp><bib-version>v2</bib-version><id>13938</id><entry>2013-01-21</entry><title>Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010</title><swanseaauthors><author><sid>4bdcc94332b2bd10530c5e71ceb04f14</sid><ORCID>0000-0001-7096-7688</ORCID><firstname>Belinda</firstname><surname>Gabbe</surname><name>Belinda Gabbe</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>83efcf2a9dfcf8b55586999d3d152ac6</sid><ORCID>0000-0001-5225-000X</ORCID><firstname>Ronan</firstname><surname>Lyons</surname><name>Ronan Lyons</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2013-01-21</date><deptcode>FGMHL</deptcode><abstract>Background Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion andmonitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at theglobal and regional level. Neither eff ort quantifi ed uncertainty in prevalence or years lived with disability (YLDs).Methods Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, andexcess mortality. Sources included published studies, case notifi cation, population-based cancer registries, otherdisease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys,other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, andlarge methodological variation between data sources. For some disorders, we used natural history models, geospatialmodels, back-calculation models (models calculating incidence from population mortality rates and case fatality), orregistration completeness models (models adjusting for incomplete registration with health-system access and othercovariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs bycause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We includeduncertainty estimates at all stages of the analysis.Findings Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated(correlation coeffi cient –0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. Themain contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes orendocrine diseases. The leading specifi c causes of YLDs were much the same in 2010 as they were in 1990: low backpain, major depressive disorder, iron-defi ciency anaemia, neck pain, chronic obstructive pulmonary disease, anxietydisorders, migraine, diabetes, and falls. Age-specifi c prevalence of YLDs increased with age in all regions and hasdecreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar comparedwith years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, andanaemia were important causes of YLDs in sub-Saharan Africa.Interpretation Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age.Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalencesof the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, havenot decreased. Health systems will need to address the needs of the rising numbers of individuals with a range ofdisorders that largely cause disability but not mortality. Quantifi cation of the burden of non-fatal health outcomes willbe crucial to understand how well health systems are responding to these challenges. Effective and affordablestrategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.</abstract><type>Journal Article</type><journal>The Lancet</journal><volume>380</volume><journalNumber>9859</journalNumber><paginationStart>2163</paginationStart><paginationEnd>2196</paginationEnd><publisher/><issnPrint>0140-6736</issnPrint><issnElectronic/><keywords/><publishedDay>15</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2012</publishedYear><publishedDate>2012-12-15</publishedDate><doi>10.1016/S0140-6736(12)61729-2</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine, Health and Life Science - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGMHL</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2015-12-08T11:03:39.4018291</lastEdited><Created>2013-01-21T11:15:22.3978733</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Theo</firstname><surname>Vos</surname><order>1</order></author><author><firstname>Abraham D</firstname><surname>Flaxman</surname><order>2</order></author><author><firstname>Mohsen</firstname><surname>Naghavi</surname><order>3</order></author><author><firstname>Rafael</firstname><surname>Lozano</surname><order>4</order></author><author><firstname>Catherine</firstname><surname>Michaud</surname><order>5</order></author><author><firstname>Majid</firstname><surname>Ezzati</surname><order>6</order></author><author><firstname>Kenji</firstname><surname>Shibuya</surname><order>7</order></author><author><firstname>Joshua 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2015-12-08T11:03:39.4018291 v2 13938 2013-01-21 Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 4bdcc94332b2bd10530c5e71ceb04f14 0000-0001-7096-7688 Belinda Gabbe Belinda Gabbe true false 83efcf2a9dfcf8b55586999d3d152ac6 0000-0001-5225-000X Ronan Lyons Ronan Lyons true false 2013-01-21 FGMHL Background Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion andmonitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at theglobal and regional level. Neither eff ort quantifi ed uncertainty in prevalence or years lived with disability (YLDs).Methods Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, andexcess mortality. Sources included published studies, case notifi cation, population-based cancer registries, otherdisease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys,other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, andlarge methodological variation between data sources. For some disorders, we used natural history models, geospatialmodels, back-calculation models (models calculating incidence from population mortality rates and case fatality), orregistration completeness models (models adjusting for incomplete registration with health-system access and othercovariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs bycause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We includeduncertainty estimates at all stages of the analysis.Findings Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated(correlation coeffi cient –0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. Themain contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes orendocrine diseases. The leading specifi c causes of YLDs were much the same in 2010 as they were in 1990: low backpain, major depressive disorder, iron-defi ciency anaemia, neck pain, chronic obstructive pulmonary disease, anxietydisorders, migraine, diabetes, and falls. Age-specifi c prevalence of YLDs increased with age in all regions and hasdecreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar comparedwith years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, andanaemia were important causes of YLDs in sub-Saharan Africa.Interpretation Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age.Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalencesof the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, havenot decreased. Health systems will need to address the needs of the rising numbers of individuals with a range ofdisorders that largely cause disability but not mortality. Quantifi cation of the burden of non-fatal health outcomes willbe crucial to understand how well health systems are responding to these challenges. Effective and affordablestrategies to deal with this rising burden are an urgent priority for health systems in most parts of the world. Journal Article The Lancet 380 9859 2163 2196 0140-6736 15 12 2012 2012-12-15 10.1016/S0140-6736(12)61729-2 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2015-12-08T11:03:39.4018291 2013-01-21T11:15:22.3978733 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Theo Vos 1 Abraham D Flaxman 2 Mohsen Naghavi 3 Rafael Lozano 4 Catherine Michaud 5 Majid Ezzati 6 Kenji Shibuya 7 Joshua A Salomon 8 Safa Abdalla 9 Victor Aboyans 10 Jerry Abraham 11 Ilana Ackerman 12 Rakesh Aggarwal 13 Stephanie Y Ahn 14 Mohammed K Ali 15 Miriam Alvarado 16 H Ross Anderson 17 Laurie M Anderson 18 Kathryn G Andrews 19 Charles Atkinson 20 Larry M Baddour 21 Adil N Bahalim 22 Suzanne Barker-Collo 23 Lope H Barrero 24 David H Bartels 25 Maria-Gloria Basáñez 26 Amanda Baxter 27 Michelle L Bell 28 Emelia J Benjamin 29 Derrick Bennett 30 Eduardo Bernabé 31 Kavi Bhalla 32 Bishal Bhandari 33 Boris Bikbov 34 Aref Bin Abdulhak 35 Gretchen Birbeck 36 James A Black 37 Hannah Blencowe 38 Jed D Blore 39 Fiona Blyth 40 Ian Bolliger 41 Audrey Bonaventure 42 Soufiane Boufous 43 Rupert Bourne 44 Michel Boussinesq 45 Tasanee Braithwaite 46 Carol Brayne 47 Lisa Bridgett 48 Simon Brooker 49 Peter Brooks 50 Traolach S Brugha 51 Claire Bryan-Hancock 52 Chiara Bucello 53 Rachelle Buchbinder 54 Geoffrey Buckle 55 Christine M Budke 56 Michael Burch 57 Peter Burney 58 Roy Burstein 59 Bianca Calabria 60 Benjamin Campbell 61 Charles E Canter 62 Hélène Carabin 63 Jonathan Carapetis 64 Loreto Carmona 65 Claudia Cella 66 Fiona Charlson 67 Honglei Chen 68 Andrew Tai-Ann Cheng 69 David Chou 70 Sumeet S Chugh 71 Luc E Coffeng 72 Steven D Colan 73 Samantha Colquhoun 74 K Ellicott Colson 75 John Condon 76 Myles D Connor 77 Leslie T Cooper 78 Matthew Corriere 79 Monica Cortinovis 80 Karen Courville de Vaccaro 81 William Couser 82 Benjamin C Cowie 83 Michael H Criqui 84 Marita Cross 85 Kaustubh C Dabhadkar 86 Manu Dahiya 87 Nabila Dahodwala 88 James Damsere-Derry 89 Goodarz Danaei 90 Adrian Davis 91 Diego De Leo 92 Louisa Degenhardt 93 Robert Dellavalle 94 Allyne Delossantos 95 Julie Denenberg 96 Sarah Derrett 97 Don C Des Jarlais 98 Samath D Dharmaratne 99 Mukesh Dherani 100 Cesar Diaz-Torne 101 Helen Dolk 102 E Ray Dorsey 103 Tim Driscoll 104 Herbert Duber 105 Beth Ebel 106 Karen Edmond 107 Alexis Elbaz 108 Suad Eltahir Ali 109 Holly Erskine 110 Patricia J Erwin 111 Patricia Espindola 112 Stalin E Ewoigbokhan 113 Farshad Farzadfar 114 Valery Feigin 115 David T Felson 116 Alize Ferrari 117 Cleusa P Ferri 118 Eric M Fèvre 119 Mariel M Finucane 120 Seth Flaxman 121 Louise Flood 122 Kyle Foreman 123 Mohammad H Forouzanfar 124 Francis Gerry R Fowkes 125 Richard Franklin 126 Marlene Fransen 127 Michael K Freeman 128 Belinda Gabbe 0000-0001-7096-7688 129 Sherine E Gabriel 130 Emmanuela Gakidou 131 Hammad A Ganatra 132 Bianca Garcia 133 Flavio Gaspari 134 Richard F Gillum 135 Gerhard Gmel 136 Richard Gosselin 137 Rebecca Grainger 138 Justina Groeger 139 Francis Guillemin 140 David Gunnell 141 Ramyani Gupta 142 Juanita Haagsma 143 Holly Hagan 144 Yara A Halasa 145 Wayne Hall 146 Diana Haring 147 Josep Maria Haro 148 James E Harrison 149 Rasmus Havmoeller 150 Roderick J Hay 151 Hideki Higashi 152 Catherine Hill 153 Bruno Hoen 154 Howard Hoffman 155 Peter J Hotez 156 Damian Hoy 157 John J Huang 158 Sydney E Ibeanusi 159 Kathryn H Jacobsen 160 Spencer L James 161 Deborah Jarvis 162 Rashmi Jasrasaria 163 Sudha Jayaraman 164 Nicole Johns 165 Jost B Jonas 166 Ganesan Karthikeyan 167 Nicholas Kassebaum 168 Norito Kawakami 169 Andre Keren 170 Jon-Paul Khoo 171 Charles H King 172 Lisa Marie Knowlton 173 Olive Kobusingye 174 Adofo Koranteng 175 Rita Krishnamurthi 176 Ratilal Lalloo 177 Laura L Laslett 178 Tim Lathlean 179 Janet L Leasher 180 Yong Yi Lee 181 James Leigh 182 Stephen S Lim 183 Elizabeth Limb 184 John Kent Lin 185 Michael Lipnick 186 Steven E Lipshultz 187 Wei Liu 188 Maria Loane 189 Summer Lockett Ohno 190 Ronan Lyons 0000-0001-5225-000X 191 Ma Jixiang 192 Jacqueline Mabweijano 193 Michael F MacIntyre 194 Reza Malekzadeh 195 Leslie Mallinger 196 Sivabalan Manivannan 197 Wagner Marcenes 198 Lyn March 199 David J Margolis 200 Guy B Marks 201 Robin Marks 202 Akira Matsumori 203 Richard Matzopoulos 204 Bongani M Mayosi 205 John H McAnulty 206 Mary M McDermott 207 Neil McGill 208 John McGrath 209 Maria Elena Medina-Mora 210 Michele Meltzer 211 George A Mensah 212 Tony R Merriman 213 Ana-Claire Meyer 214 Valeria Miglioli 215 Matthew Miller 216 Ted R Miller 217 Philip B Mitchell 218 Ana Olga Mocumbi 219 Terrie E Moffitt 220 Ali A Mokdad 221 Lorenzo Monasta 222 Marcella Montico 223 Maziar Moradi-Lakeh 224 Andrew Moran 225 Lidia Morawska 226 Rintaro Mori 227 Michele E Murdoch 228 Michael K Mwaniki 229 Kovin Naidoo 230 M Nathan Nair 231 Luigi Naldi 232 KM Venkat Narayan 233 Paul K Nelson 234 Robert G Nelson 235 Michael C Nevitt 236 Charles R Newton 237 Sandra Nolte 238 Paul Norman 239 Rosana Norman 240 Martin O'Donnell 241 Simon O'Hanlon 242 Casey Olives 243 Saad B Omer 244 Katrina Ortblad 245 Richard Osborne 246 Doruk Ozgediz 247 Andrew Page 248 Bishnu Pahari 249 Jeyaraj Durai Pandian 250 Andrea Panozo Rivero 251 Scott B Patten 252 Neil Pearce 253 Rogelio Perez Padilla 254 Fernando Perez-Ruiz 255 Norberto Perico 256 Konrad Pesudovs 257 David Phillips 258 Michael R Phillips 259 Kelsey Pierce 260 Sébastien Pion 261 Guilherme V Polanczyk 262 Suzanne Polinder 263 C Arden Pope 264 Svetlana Popova 265 Esteban Porrini 266 Farshad Pourmalek 267 Martin Prince 268 Rachel L Pullan 269 Kapa D Ramaiah 270 Dharani Ranganathan 271 Homie Razavi 272 Mathilda Regan 273 Jürgen T Rehm 274 David B Rein 275 Guiseppe Remuzzi 276 Kathryn Richardson 277 Frederick P Rivara 278 Thomas Roberts 279 Carolyn Robinson 280 Felipe Rodriguez De Leòn 281 Luca Ronfani 282 Robin Room 283 Lisa C Rosenfeld 284 Lesley Rushton 285 Ralph L Sacco 286 Sukanta Saha 287 Uchechukwu Sampson 288 Lidia Sanchez-Riera 289 Ella Sanman 290 David C Schwebel 291 James Graham Scott 292 Maria Segui-Gomez 293 Saeid Shahraz 294 Donald S Shepard 295 Hwashin Shin 296 Rupak Shivakoti 297 David Singh 298 Gitanjali M Singh 299 Jasvinder A Singh 300 Jessica Singleton 301 David A Sleet 302 Karen Sliwa 303 Emma Smith 304 Jennifer L Smith 305 Nicolas JC Stapelberg 306 Andrew Steer 307 Timothy Steiner 308 Wilma A Stolk 309 Lars Jacob Stovner 310 Christopher Sudfeld 311 Sana Syed 312 Giorgio Tamburlini 313 Mohammad Tavakkoli 314 Hugh R Taylor 315 Jennifer A Taylor 316 William J Taylor 317 Bernadette Thomas 318 W Murray Thomson 319 George D Thurston 320 Imad M Tleyjeh 321 Marcello Tonelli 322 Jeffrey A Towbin 323 Thomas Truelsen 324 Miltiadis K Tsilimbaris 325 Clotilde Ubeda 326 Eduardo A Undurraga 327 Marieke J van der Werf 328 Os Jim van 329 Monica S Vavilala 330 N Venketasubramanian 331 Mengru Wang 332 Wenzhi Wang 333 Kerrianne Watt 334 David J Weatherall 335 Martin A Weinstock 336 Robert Weintraub 337 Marc G Weisskopf 338 Myrna M Weissman 339 Richard A White 340 Harvey Whiteford 341 Steven T Wiersma 342 James D Wilkinson 343 Hywel C Williams 344 Sean RM Williams 345 Emma Witt 346 Frederick Wolfe 347 Anthony D Woolf 348 Sarah Wulf 349 Pon-Hsiu Yeh 350 Anita KM Zaidi 351 Zhi-Jie Zheng 352 David Zonies 353 Alan D Lopez 354 Christopher JL Murray 355 |
title |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 |
spellingShingle |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 Belinda Gabbe Ronan Lyons |
title_short |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 |
title_full |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 |
title_fullStr |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 |
title_full_unstemmed |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 |
title_sort |
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 |
author_id_str_mv |
4bdcc94332b2bd10530c5e71ceb04f14 83efcf2a9dfcf8b55586999d3d152ac6 |
author_id_fullname_str_mv |
4bdcc94332b2bd10530c5e71ceb04f14_***_Belinda Gabbe 83efcf2a9dfcf8b55586999d3d152ac6_***_Ronan Lyons |
author |
Belinda Gabbe Ronan Lyons |
author2 |
Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M Baddour Adil N Bahalim Suzanne Barker-Collo Lope H Barrero David H Bartels Maria-Gloria Basáñez Amanda Baxter Michelle L Bell Emelia J Benjamin Derrick Bennett Eduardo Bernabé Kavi Bhalla Bishal Bhandari Boris Bikbov Aref Bin Abdulhak Gretchen Birbeck James A Black Hannah Blencowe Jed D Blore Fiona Blyth Ian Bolliger Audrey Bonaventure Soufiane Boufous Rupert Bourne Michel Boussinesq Tasanee Braithwaite Carol Brayne Lisa Bridgett Simon Brooker Peter Brooks Traolach S Brugha Claire Bryan-Hancock Chiara Bucello Rachelle Buchbinder Geoffrey Buckle Christine M Budke Michael Burch Peter Burney Roy Burstein Bianca Calabria Benjamin Campbell Charles E Canter Hélène Carabin Jonathan Carapetis Loreto Carmona Claudia Cella Fiona Charlson Honglei Chen Andrew Tai-Ann Cheng David Chou Sumeet S Chugh Luc E Coffeng Steven D Colan Samantha Colquhoun K Ellicott Colson John Condon Myles D Connor Leslie T Cooper Matthew Corriere Monica Cortinovis Karen Courville de Vaccaro William Couser Benjamin C Cowie Michael H Criqui Marita Cross Kaustubh C Dabhadkar Manu Dahiya Nabila Dahodwala James Damsere-Derry Goodarz Danaei Adrian Davis Diego De Leo Louisa Degenhardt Robert Dellavalle Allyne Delossantos Julie Denenberg Sarah Derrett Don C Des Jarlais Samath D Dharmaratne Mukesh Dherani Cesar Diaz-Torne Helen Dolk E Ray Dorsey Tim Driscoll Herbert Duber Beth Ebel Karen Edmond Alexis Elbaz Suad Eltahir Ali Holly Erskine Patricia J Erwin Patricia Espindola Stalin E Ewoigbokhan Farshad Farzadfar Valery Feigin David T Felson Alize Ferrari Cleusa P Ferri Eric M Fèvre Mariel M Finucane Seth Flaxman Louise Flood Kyle Foreman Mohammad H Forouzanfar Francis Gerry R Fowkes Richard Franklin Marlene Fransen Michael K Freeman Belinda Gabbe Sherine E Gabriel Emmanuela Gakidou Hammad A Ganatra Bianca Garcia Flavio Gaspari Richard F Gillum Gerhard Gmel Richard Gosselin Rebecca Grainger Justina Groeger Francis Guillemin David Gunnell Ramyani Gupta Juanita Haagsma Holly Hagan Yara A Halasa Wayne Hall Diana Haring Josep Maria Haro James E Harrison Rasmus Havmoeller Roderick J Hay Hideki Higashi Catherine Hill Bruno Hoen Howard Hoffman Peter J Hotez Damian Hoy John J Huang Sydney E Ibeanusi Kathryn H Jacobsen Spencer L James Deborah Jarvis Rashmi Jasrasaria Sudha Jayaraman Nicole Johns Jost B Jonas Ganesan Karthikeyan Nicholas Kassebaum Norito Kawakami Andre Keren Jon-Paul Khoo Charles H King Lisa Marie Knowlton Olive Kobusingye Adofo Koranteng Rita Krishnamurthi Ratilal Lalloo Laura L Laslett Tim Lathlean Janet L Leasher Yong Yi Lee James Leigh Stephen S Lim Elizabeth Limb John Kent Lin Michael Lipnick Steven E Lipshultz Wei Liu Maria Loane Summer Lockett Ohno Ronan Lyons Ma Jixiang Jacqueline Mabweijano Michael F MacIntyre Reza Malekzadeh Leslie Mallinger Sivabalan Manivannan Wagner Marcenes Lyn March David J Margolis Guy B Marks Robin Marks Akira Matsumori Richard Matzopoulos Bongani M Mayosi John H McAnulty Mary M McDermott Neil McGill John McGrath Maria Elena Medina-Mora Michele Meltzer George A Mensah Tony R Merriman Ana-Claire Meyer Valeria Miglioli Matthew Miller Ted R Miller Philip B Mitchell Ana Olga Mocumbi Terrie E Moffitt Ali A Mokdad Lorenzo Monasta Marcella Montico Maziar Moradi-Lakeh Andrew Moran Lidia Morawska Rintaro Mori Michele E Murdoch Michael K Mwaniki Kovin Naidoo M Nathan Nair Luigi Naldi KM Venkat Narayan Paul K Nelson Robert G Nelson Michael C Nevitt Charles R Newton Sandra Nolte Paul Norman Rosana Norman Martin O'Donnell Simon O'Hanlon Casey Olives Saad B Omer Katrina Ortblad Richard Osborne Doruk Ozgediz Andrew Page Bishnu Pahari Jeyaraj Durai Pandian Andrea Panozo Rivero Scott B Patten Neil Pearce Rogelio Perez Padilla Fernando Perez-Ruiz Norberto Perico Konrad Pesudovs David Phillips Michael R Phillips Kelsey Pierce Sébastien Pion Guilherme V Polanczyk Suzanne Polinder C Arden Pope Svetlana Popova Esteban Porrini Farshad Pourmalek Martin Prince Rachel L Pullan Kapa D Ramaiah Dharani Ranganathan Homie Razavi Mathilda Regan Jürgen T Rehm David B Rein Guiseppe Remuzzi Kathryn Richardson Frederick P Rivara Thomas Roberts Carolyn Robinson Felipe Rodriguez De Leòn Luca Ronfani Robin Room Lisa C Rosenfeld Lesley Rushton Ralph L Sacco Sukanta Saha Uchechukwu Sampson Lidia Sanchez-Riera Ella Sanman David C Schwebel James Graham Scott Maria Segui-Gomez Saeid Shahraz Donald S Shepard Hwashin Shin Rupak Shivakoti David Singh Gitanjali M Singh Jasvinder A Singh Jessica Singleton David A Sleet Karen Sliwa Emma Smith Jennifer L Smith Nicolas JC Stapelberg Andrew Steer Timothy Steiner Wilma A Stolk Lars Jacob Stovner Christopher Sudfeld Sana Syed Giorgio Tamburlini Mohammad Tavakkoli Hugh R Taylor Jennifer A Taylor William J Taylor Bernadette Thomas W Murray Thomson George D Thurston Imad M Tleyjeh Marcello Tonelli Jeffrey A Towbin Thomas Truelsen Miltiadis K Tsilimbaris Clotilde Ubeda Eduardo A Undurraga Marieke J van der Werf Os Jim van Monica S Vavilala N Venketasubramanian Mengru Wang Wenzhi Wang Kerrianne Watt David J Weatherall Martin A Weinstock Robert Weintraub Marc G Weisskopf Myrna M Weissman Richard A White Harvey Whiteford Steven T Wiersma James D Wilkinson Hywel C Williams Sean RM Williams Emma Witt Frederick Wolfe Anthony D Woolf Sarah Wulf Pon-Hsiu Yeh Anita KM Zaidi Zhi-Jie Zheng David Zonies Alan D Lopez Christopher JL Murray |
format |
Journal article |
container_title |
The Lancet |
container_volume |
380 |
container_issue |
9859 |
container_start_page |
2163 |
publishDate |
2012 |
institution |
Swansea University |
issn |
0140-6736 |
doi_str_mv |
10.1016/S0140-6736(12)61729-2 |
college_str |
Faculty of Medicine, Health and Life Sciences |
hierarchytype |
|
hierarchy_top_id |
facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
document_store_str |
0 |
active_str |
0 |
description |
Background Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion andmonitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at theglobal and regional level. Neither eff ort quantifi ed uncertainty in prevalence or years lived with disability (YLDs).Methods Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, andexcess mortality. Sources included published studies, case notifi cation, population-based cancer registries, otherdisease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys,other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, andlarge methodological variation between data sources. For some disorders, we used natural history models, geospatialmodels, back-calculation models (models calculating incidence from population mortality rates and case fatality), orregistration completeness models (models adjusting for incomplete registration with health-system access and othercovariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs bycause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We includeduncertainty estimates at all stages of the analysis.Findings Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated(correlation coeffi cient –0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. Themain contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes orendocrine diseases. The leading specifi c causes of YLDs were much the same in 2010 as they were in 1990: low backpain, major depressive disorder, iron-defi ciency anaemia, neck pain, chronic obstructive pulmonary disease, anxietydisorders, migraine, diabetes, and falls. Age-specifi c prevalence of YLDs increased with age in all regions and hasdecreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar comparedwith years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, andanaemia were important causes of YLDs in sub-Saharan Africa.Interpretation Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age.Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalencesof the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, havenot decreased. Health systems will need to address the needs of the rising numbers of individuals with a range ofdisorders that largely cause disability but not mortality. Quantifi cation of the burden of non-fatal health outcomes willbe crucial to understand how well health systems are responding to these challenges. Effective and affordablestrategies to deal with this rising burden are an urgent priority for health systems in most parts of the world. |
published_date |
2012-12-15T03:15:56Z |
_version_ |
1763750295163109376 |
score |
11.021648 |