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Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal

Julian Halcox Orcid Logo

EHJ, Volume: 33, Pages: 1502 - 1510

Swansea University Author: Julian Halcox Orcid Logo

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DOI (Published version): 10.1093/eurheartj/ehq062

Abstract

Aims To assess the feasibility and reproducibility of non-invasive vascular assessment in a childhood population setting and identify the determinants of vascular phenotype in early life. Methodsandresults We studied 7557 children (age 9.8–12.3 years) participating in the Avon Longitudinal Study of...

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Published in: EHJ
Published: 2010
URI: https://cronfa.swan.ac.uk/Record/cronfa16045
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spelling 2013-09-18T12:49:30.8165107 v2 16045 2013-09-18 Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal 3676f695eeda169d0f8c618adf27c04b 0000-0001-6926-2947 Julian Halcox Julian Halcox true false 2013-09-18 HDAT Aims To assess the feasibility and reproducibility of non-invasive vascular assessment in a childhood population setting and identify the determinants of vascular phenotype in early life. Methodsandresults We studied 7557 children (age 9.8–12.3 years) participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Six research technicians underwent a 5-month training protocol to enable study of brachial artery endo-thelial function by flow-mediated dilatation (FMD) and arterial stiffness by carotid to radial pulse wave velocity (PWV) and brachial distensibility [distensibility coefficient (DC)]. Reproducibility studies were performed at the beginning, the middle, and the end of the study. A blinded repeat evaluation of a random selection of 3% of the cohort was also undertaken throughout the study. The effect of anthropometric and environmental factors on each measure was examined. Successful measures were obtained in 88, 95, and 87% of the studied children for FMD, PWV, and DC, respectively. The coefficients of variation between technicians for FMD, PWV, and DC were 10.5, 4.6, and 6.6% at the beginning of the study and reached 7.7, 4.1, and 10% at the end. Baseline vessel diameter and gender were important determinants of all the vascular measures, with a small effect of room and skin temperatures on FMD and PWV. Boys consistently had lower FMD and DC and higher PWV measures (P,0.01 for all). Conclusion Reproducible, high-quality assessments of vascular structure and function in children can be made on a large scale in field studies by suitably trained non-specialist operators. This study provides an invaluable resource for assessing the impact of early influences, genetic, and environmental factors on arterial phenotype. Journal Article EHJ 33 1502 1510 ALSPAC, Vascular, Children, Endothelial function, Reproducibility 31 12 2010 2010-12-31 10.1093/eurheartj/ehq062 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University 2013-09-18T12:49:30.8165107 2013-09-18T12:43:13.0686073 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Julian Halcox 0000-0001-6926-2947 1
title Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal
spellingShingle Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal
Julian Halcox
title_short Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal
title_full Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal
title_fullStr Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal
title_full_unstemmed Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal
title_sort Determinants of vascular phenotype in a large childhood population: the Avon Longitudinal
author_id_str_mv 3676f695eeda169d0f8c618adf27c04b
author_id_fullname_str_mv 3676f695eeda169d0f8c618adf27c04b_***_Julian Halcox
author Julian Halcox
author2 Julian Halcox
format Journal article
container_title EHJ
container_volume 33
container_start_page 1502
publishDate 2010
institution Swansea University
doi_str_mv 10.1093/eurheartj/ehq062
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
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description Aims To assess the feasibility and reproducibility of non-invasive vascular assessment in a childhood population setting and identify the determinants of vascular phenotype in early life. Methodsandresults We studied 7557 children (age 9.8–12.3 years) participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Six research technicians underwent a 5-month training protocol to enable study of brachial artery endo-thelial function by flow-mediated dilatation (FMD) and arterial stiffness by carotid to radial pulse wave velocity (PWV) and brachial distensibility [distensibility coefficient (DC)]. Reproducibility studies were performed at the beginning, the middle, and the end of the study. A blinded repeat evaluation of a random selection of 3% of the cohort was also undertaken throughout the study. The effect of anthropometric and environmental factors on each measure was examined. Successful measures were obtained in 88, 95, and 87% of the studied children for FMD, PWV, and DC, respectively. The coefficients of variation between technicians for FMD, PWV, and DC were 10.5, 4.6, and 6.6% at the beginning of the study and reached 7.7, 4.1, and 10% at the end. Baseline vessel diameter and gender were important determinants of all the vascular measures, with a small effect of room and skin temperatures on FMD and PWV. Boys consistently had lower FMD and DC and higher PWV measures (P,0.01 for all). Conclusion Reproducible, high-quality assessments of vascular structure and function in children can be made on a large scale in field studies by suitably trained non-specialist operators. This study provides an invaluable resource for assessing the impact of early influences, genetic, and environmental factors on arterial phenotype.
published_date 2010-12-31T03:18:19Z
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score 11.016235

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