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Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia / Jeremy, Tree

Cortex, Volume: 50, Pages: 55 - 63

Swansea University Author: Jeremy, Tree

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DOI (Published version): 10.1016/j.cortex.2013.08.006

Abstract

Developmental prosopagnosia (DP) is characterised by a severe lifelong impairment in face recognition. In recent years it has become clear that DP affects a substantial number of people, yet little work has attempted to improve face processing in these individuals. Intriguingly, recent evidence sugg...

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Published in: Cortex
Published: 2015
URI: https://cronfa.swan.ac.uk/Record/cronfa16861
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spelling 2019-03-05T23:44:11.3755461 v2 16861 2014-01-10 Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia 373fd575114a743d502a979c6161b1ad 0000-0001-6000-8125 Jeremy Tree Jeremy Tree true false 2014-01-10 HPS Developmental prosopagnosia (DP) is characterised by a severe lifelong impairment in face recognition. In recent years it has become clear that DP affects a substantial number of people, yet little work has attempted to improve face processing in these individuals. Intriguingly, recent evidence suggests that intranasal inhalation of the hormone oxytocin can improve face processing in unimpaired participants, and we investigated whether similar findings might be noted in DP. Ten adults with DP and 10 matched controls were tested using a randomized placebo-controlled double-blind within-subject experimental design (AB-BA). Each participant took part in two testing sessions separated by a 14–25 day interval. In each session, participants inhaled 24 IU of oxytocin or placebo spray, followed by a 45 min resting period to allow central oxytocin levels to plateau. Participants then completed two face processing tests: one assessing memory for a set of newly encoded faces, and one measuring the ability to match simultaneously presented faces according to identity. Participants completed the Multidimensional Mood Questionnaire (MMQ) at three points in each testing session to assess the possible mood-altering effects of oxytocin and to control for attention and wakefulness. Statistical comparisons revealed an improvement for DP but not control participants on both tests in the oxytocin condition, and analysis of scores on the MMQ indicated that the effect cannot be attributed to changes in mood, attention or wakefulness. This investigation provides the first evidence that oxytocin can improve face processing in DP, and the potential neural underpinnings of the findings are discussed alongside their implications for the treatment of face processing disorders. Journal Article Cortex 50 55 63 31 12 2015 2015-12-31 10.1016/j.cortex.2013.08.006 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2019-03-05T23:44:11.3755461 2014-01-10T16:11:48.7306465 College of Human and Health Sciences Psychology Sarah Bate 1 Sarah J Cook 2 Bradley Duchaine 3 Jeremy Tree 0000-0001-6000-8125 4 Edwin J Burns 5 Timothy L Hodgson 6
title Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
spellingShingle Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
Jeremy, Tree
title_short Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
title_full Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
title_fullStr Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
title_full_unstemmed Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
title_sort Intranasal inhalation of oxytocin improves face processing in developmental prosopagnosia
author_id_str_mv 373fd575114a743d502a979c6161b1ad
author_id_fullname_str_mv 373fd575114a743d502a979c6161b1ad_***_Jeremy, Tree
author Jeremy, Tree
format Journal article
container_title Cortex
container_volume 50
container_start_page 55
publishDate 2015
institution Swansea University
doi_str_mv 10.1016/j.cortex.2013.08.006
college_str College of Human and Health Sciences
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hierarchy_top_id collegeofhumanandhealthsciences
hierarchy_top_title College of Human and Health Sciences
hierarchy_parent_id collegeofhumanandhealthsciences
hierarchy_parent_title College of Human and Health Sciences
department_str Psychology{{{_:::_}}}College of Human and Health Sciences{{{_:::_}}}Psychology
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description Developmental prosopagnosia (DP) is characterised by a severe lifelong impairment in face recognition. In recent years it has become clear that DP affects a substantial number of people, yet little work has attempted to improve face processing in these individuals. Intriguingly, recent evidence suggests that intranasal inhalation of the hormone oxytocin can improve face processing in unimpaired participants, and we investigated whether similar findings might be noted in DP. Ten adults with DP and 10 matched controls were tested using a randomized placebo-controlled double-blind within-subject experimental design (AB-BA). Each participant took part in two testing sessions separated by a 14–25 day interval. In each session, participants inhaled 24 IU of oxytocin or placebo spray, followed by a 45 min resting period to allow central oxytocin levels to plateau. Participants then completed two face processing tests: one assessing memory for a set of newly encoded faces, and one measuring the ability to match simultaneously presented faces according to identity. Participants completed the Multidimensional Mood Questionnaire (MMQ) at three points in each testing session to assess the possible mood-altering effects of oxytocin and to control for attention and wakefulness. Statistical comparisons revealed an improvement for DP but not control participants on both tests in the oxytocin condition, and analysis of scores on the MMQ indicated that the effect cannot be attributed to changes in mood, attention or wakefulness. This investigation provides the first evidence that oxytocin can improve face processing in DP, and the potential neural underpinnings of the findings are discussed alongside their implications for the treatment of face processing disorders.
published_date 2015-12-31T04:00:10Z
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