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Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice / Xuefei Cao, Roberta A. Mittelstaedt, Mason G. Pearce, Bruce C. Allen, Lya G. Soeteman-Hernández, George Johnson, C. Anita H. Bigger, Robert H. Heflich

Environmental and Molecular Mutagenesis, Pages: n/a - n/a

Swansea University Author: George Johnson

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DOI (Published version): 10.1002/em.21854

Published in: Environmental and Molecular Mutagenesis
Published: 2014
Online Access: http://onlinelibrary.wiley.com/doi/10.1002/em.21854/abstract
URI: https://cronfa.swan.ac.uk/Record/cronfa17347
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Item Description: The paper has been selected for Editors Choice. http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2280/homepage/editor_s_choice.htm. This is a high accolade and an official letter was sent from EMM to senior US-FDA-NCTR staff including Director William (Bill) Slikker stating the importance of this paper to human health risk assessment. It is of high impact and follows on from the story of Roche's EMS impurity in Viracept, showing that the threshold dose and safe human dose (PDE) is reduced when a different system is used.
College: Swansea University Medical School
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