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Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice / Xuefei Cao; Roberta A. Mittelstaedt; Mason G. Pearce; Bruce C. Allen; Lya G. Soeteman-Hernández; George Johnson; C. Anita H. Bigger; Robert H. Heflich
Environmental and Molecular Mutagenesis, Pages: n/a - n/a
Swansea University Author: George, Johnson
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DOI (Published version): 10.1002/em.21854
Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adultgpt-delta transgenic mice
|Published in:||Environmental and Molecular Mutagenesis|
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The paper has been selected for Editors Choice. http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2280/homepage/editor_s_choice.htm. This is a high accolade and an official letter was sent from EMM to senior US-FDA-NCTR staff including Director William (Bill) Slikker stating the importance of this paper to human health risk assessment. It is of high impact and follows on from the story of Roche's EMS impurity in Viracept, showing that the threshold dose and safe human dose (PDE) is reduced when a different system is used.
Swansea University Medical School