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The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation / Jeffrey, Davies

Psychoneuroendocrinology, Volume: 51, Pages: 431 - 439

Swansea University Author: Jeffrey, Davies

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DOI (Published version): 10.1016/j.psyneuen.2014.10.015

Abstract

An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for...

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Published in: Psychoneuroendocrinology
Published: 2014
Online Access: http://www.sciencedirect.com/science/article/pii/S0306453014003990
URI: https://cronfa.swan.ac.uk/Record/cronfa19690
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Abstract: An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8–10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain.
Keywords: Adult hippocampal neurogenesis; Ghrelin; Pattern separation
College: Swansea University Medical School
Start Page: 431
End Page: 439