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Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections

Bethany L Dearlove, Alison J Cody, Ben Pascoe Orcid Logo, Guillaume Méric, Daniel J Wilson, Samuel K Sheppard, Guillaume Meric

The ISME Journal

Swansea University Authors: Ben Pascoe Orcid Logo, Guillaume Meric

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DOI (Published version): 10.1038/ismej.2015.149

Abstract

Campylobacter jejuni and Campylobacter coli are the biggest causes of bacterial gastroenteritis in the developed world, with human infections typically arising from zoonotic transmission associated with infected meat, especially poultry. Because this organism is not thought to survive well outside o...

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Published in: The ISME Journal
Published: 2015
URI: https://cronfa.swan.ac.uk/Record/cronfa20103
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first_indexed 2015-04-20T02:06:02Z
last_indexed 2019-07-01T19:35:12Z
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spelling 2019-07-01T16:49:36.8962596 v2 20103 2015-01-29 Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections 4660c0eb7e6bfd796cd749ae713ea558 0000-0001-6376-5121 Ben Pascoe Ben Pascoe true false 9384e450ee619395be7459d6bd7a8f6d Guillaume Meric Guillaume Meric true false 2015-01-29 PMSC Campylobacter jejuni and Campylobacter coli are the biggest causes of bacterial gastroenteritis in the developed world, with human infections typically arising from zoonotic transmission associated with infected meat, especially poultry. Because this organism is not thought to survive well outside of the gut, host associated populations are genetically isolated to varying degrees. Therefore the likely origin of most Campylobacter strains can be determined by host associated variations in the genome. This is instructive for characterizing the source of human infection, at the population level, using seven-locus multilocus sequence typing. However, some common strains, notably isolates belonging to the ST-21, ST-45 and ST-828 clonal complexes, appear to have broad host ranges, hindering source attribution. Whole genome sequencing has the potential to reveal fine-scale genetic structure associated with host specificity within each of these strains. Here we report that, surprisingly, rates of zoonotic transmission among animal species within these strains are so high that whole genomes confer limited power to pinpoint the host animal reservoir. Our results are consistent with adaptation of these strains to a generalist lifestyle, allowing them to exploit opportunities for rapid transmission between mammal and bird hosts. Further, they indicate that pinpointing the source of individual human infections via genomics will require intensive sampling of animal reservoir populations. Journal Article The ISME Journal 25 8 2015 2015-08-25 10.1038/ismej.2015.149 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2019-07-01T16:49:36.8962596 2015-01-29T01:17:18.9897883 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Bethany L Dearlove 1 Alison J Cody 2 Ben Pascoe 0000-0001-6376-5121 3 Guillaume Méric 4 Daniel J Wilson 5 Samuel K Sheppard 6 Guillaume Meric 7
title Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections
spellingShingle Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections
Ben Pascoe
Guillaume Meric
title_short Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections
title_full Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections
title_fullStr Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections
title_full_unstemmed Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections
title_sort Rapid host switching in generalist Campylobacter strains erodes the signal for tracing human infections
author_id_str_mv 4660c0eb7e6bfd796cd749ae713ea558
9384e450ee619395be7459d6bd7a8f6d
author_id_fullname_str_mv 4660c0eb7e6bfd796cd749ae713ea558_***_Ben Pascoe
9384e450ee619395be7459d6bd7a8f6d_***_Guillaume Meric
author Ben Pascoe
Guillaume Meric
author2 Bethany L Dearlove
Alison J Cody
Ben Pascoe
Guillaume Méric
Daniel J Wilson
Samuel K Sheppard
Guillaume Meric
format Journal article
container_title The ISME Journal
publishDate 2015
institution Swansea University
doi_str_mv 10.1038/ismej.2015.149
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Campylobacter jejuni and Campylobacter coli are the biggest causes of bacterial gastroenteritis in the developed world, with human infections typically arising from zoonotic transmission associated with infected meat, especially poultry. Because this organism is not thought to survive well outside of the gut, host associated populations are genetically isolated to varying degrees. Therefore the likely origin of most Campylobacter strains can be determined by host associated variations in the genome. This is instructive for characterizing the source of human infection, at the population level, using seven-locus multilocus sequence typing. However, some common strains, notably isolates belonging to the ST-21, ST-45 and ST-828 clonal complexes, appear to have broad host ranges, hindering source attribution. Whole genome sequencing has the potential to reveal fine-scale genetic structure associated with host specificity within each of these strains. Here we report that, surprisingly, rates of zoonotic transmission among animal species within these strains are so high that whole genomes confer limited power to pinpoint the host animal reservoir. Our results are consistent with adaptation of these strains to a generalist lifestyle, allowing them to exploit opportunities for rapid transmission between mammal and bird hosts. Further, they indicate that pinpointing the source of individual human infections via genomics will require intensive sampling of animal reservoir populations.
published_date 2015-08-25T03:23:41Z
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score 11.036334

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