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Localization of a Stable Neural Correlate of Associative Memory

Leon G Reijmers, Brian Perkins Orcid Logo, Naoki Matsuo, Mark Mayford

Science, Volume: 317, Issue: 5842, Pages: 1230 - 1233

Swansea University Author: Brian Perkins Orcid Logo

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DOI (Published version): 10.1126/science.1143839

Abstract

Do learning and retrieval of a memory activate the same neurons? Does the number of reactivated neurons correlate with memory strength? We developed a transgenic mouse that enables the long-lasting genetic tagging of c-fos–active neurons. We found neurons in the basolateral amygdala that are activat...

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Published in: Science
Published: 2007
Online Access: http://www.sciencemag.org/content/317/5842/1230.short
URI: https://cronfa.swan.ac.uk/Record/cronfa20485
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first_indexed 2015-03-20T03:04:00Z
last_indexed 2018-02-09T04:57:04Z
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spelling 2015-03-19T11:39:57.1633458 v2 20485 2015-03-19 Localization of a Stable Neural Correlate of Associative Memory ba13cfe67917998691f44342815a243e 0000-0001-9281-5909 Brian Perkins Brian Perkins true false 2015-03-19 PMSC Do learning and retrieval of a memory activate the same neurons? Does the number of reactivated neurons correlate with memory strength? We developed a transgenic mouse that enables the long-lasting genetic tagging of c-fos–active neurons. We found neurons in the basolateral amygdala that are activated during Pavlovian fear conditioning and are reactivated during memory retrieval. The number of reactivated neurons correlated positively with the behavioral expression of the fear memory, indicating a stable neural correlate of associative memory. The ability to manipulate these neurons genetically should allow a more precise dissection of the molecular mechanisms of memory encoding within a distributed neuronal network. Journal Article Science 317 5842 1230 1233 31 8 2007 2007-08-31 10.1126/science.1143839 http://www.sciencemag.org/content/317/5842/1230.short COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2015-03-19T11:39:57.1633458 2015-03-19T11:28:41.7895235 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Leon G Reijmers 1 Brian Perkins 0000-0001-9281-5909 2 Naoki Matsuo 3 Mark Mayford 4
title Localization of a Stable Neural Correlate of Associative Memory
spellingShingle Localization of a Stable Neural Correlate of Associative Memory
Brian Perkins
title_short Localization of a Stable Neural Correlate of Associative Memory
title_full Localization of a Stable Neural Correlate of Associative Memory
title_fullStr Localization of a Stable Neural Correlate of Associative Memory
title_full_unstemmed Localization of a Stable Neural Correlate of Associative Memory
title_sort Localization of a Stable Neural Correlate of Associative Memory
author_id_str_mv ba13cfe67917998691f44342815a243e
author_id_fullname_str_mv ba13cfe67917998691f44342815a243e_***_Brian Perkins
author Brian Perkins
author2 Leon G Reijmers
Brian Perkins
Naoki Matsuo
Mark Mayford
format Journal article
container_title Science
container_volume 317
container_issue 5842
container_start_page 1230
publishDate 2007
institution Swansea University
doi_str_mv 10.1126/science.1143839
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.sciencemag.org/content/317/5842/1230.short
document_store_str 0
active_str 0
description Do learning and retrieval of a memory activate the same neurons? Does the number of reactivated neurons correlate with memory strength? We developed a transgenic mouse that enables the long-lasting genetic tagging of c-fos–active neurons. We found neurons in the basolateral amygdala that are activated during Pavlovian fear conditioning and are reactivated during memory retrieval. The number of reactivated neurons correlated positively with the behavioral expression of the fear memory, indicating a stable neural correlate of associative memory. The ability to manipulate these neurons genetically should allow a more precise dissection of the molecular mechanisms of memory encoding within a distributed neuronal network.
published_date 2007-08-31T03:24:14Z
_version_ 1763750816821280768
score 11.037056

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