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The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice

M. Fasihul Alam, David Cohen, Christopher Butler, Frank Dunstan, Zoe Roberts, Sharon Hillier, Stephen Palmer, Fasihul Alam

International Journal of Antimicrobial Agents, Volume: 33, Issue: 3, Pages: 255 - 257

Swansea University Author: Fasihul Alam

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DOI (Published version): 10.1016/j.ijantimicag.2008.08.027

Abstract

The emergence of antibiotic resistance is a major threat to public health. In the UK, most antibiotics are prescribed in general practice but the extra costs to general practice of resistant infections have not previously been well described. We compared the costs of treating patients presenting wit...

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Published in: International Journal of Antimicrobial Agents
Published: 2009
URI: https://cronfa.swan.ac.uk/Record/cronfa20834
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first_indexed 2015-04-22T02:08:24Z
last_indexed 2018-02-09T04:57:47Z
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spelling 2015-04-21T17:37:47.7336045 v2 20834 2015-04-21 The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice 642c9290a11352cb60741fc2b1004f6d Fasihul Alam Fasihul Alam true false 2015-04-21 HHE The emergence of antibiotic resistance is a major threat to public health. In the UK, most antibiotics are prescribed in general practice but the extra costs to general practice of resistant infections have not previously been well described. We compared the costs of treating patients presenting with resistant Escherichia coli urinary tract infections (UTIs) (resistant to ampicillin, trimethoprim or at least one antibiotic) with the costs of treating patients with UTIs that were sensitive to all six tested antibiotics (ampicillin, trimethoprim, amoxicillin/clavulanic acid, cefalexin, ciprofloxacin and nitrofurantoin) with regard to re-consultations and antibiotics prescribed. There were significantly higher antibiotic costs (mean extra antibiotic cost 1.19 pounds/1.75 euros), re-consultation costs ( 2.42 pounds/3.55 euros) and total costs ( 3.62 pounds/5.31euros) for patients whose infections were resistant to at least one antibiotic compared with those with sensitive infections even after accounting for potentially confounding factors. Although these per-patient costs may appear small, they do not take into account the full additional costs of resistant UTIs in the community and, given the high prevalence of UTIs, the overall costs to the health service are substantial. Journal Article International Journal of Antimicrobial Agents 33 3 255 257 31 3 2009 2009-03-31 10.1016/j.ijantimicag.2008.08.027 COLLEGE NANME Swansea Centre for Health Economics COLLEGE CODE HHE Swansea University 2015-04-21T17:37:47.7336045 2015-04-21T17:36:42.1996849 Faculty of Medicine, Health and Life Sciences School of Health and Social Care M. Fasihul Alam 1 David Cohen 2 Christopher Butler 3 Frank Dunstan 4 Zoe Roberts 5 Sharon Hillier 6 Stephen Palmer 7 Fasihul Alam 8
title The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice
spellingShingle The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice
Fasihul Alam
title_short The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice
title_full The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice
title_fullStr The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice
title_full_unstemmed The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice
title_sort The additional costs of antibiotics and re-consultations for antibiotic-resistant Escherichia coli urinary tract infections managed in general practice
author_id_str_mv 642c9290a11352cb60741fc2b1004f6d
author_id_fullname_str_mv 642c9290a11352cb60741fc2b1004f6d_***_Fasihul Alam
author Fasihul Alam
author2 M. Fasihul Alam
David Cohen
Christopher Butler
Frank Dunstan
Zoe Roberts
Sharon Hillier
Stephen Palmer
Fasihul Alam
format Journal article
container_title International Journal of Antimicrobial Agents
container_volume 33
container_issue 3
container_start_page 255
publishDate 2009
institution Swansea University
doi_str_mv 10.1016/j.ijantimicag.2008.08.027
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care
document_store_str 0
active_str 0
description The emergence of antibiotic resistance is a major threat to public health. In the UK, most antibiotics are prescribed in general practice but the extra costs to general practice of resistant infections have not previously been well described. We compared the costs of treating patients presenting with resistant Escherichia coli urinary tract infections (UTIs) (resistant to ampicillin, trimethoprim or at least one antibiotic) with the costs of treating patients with UTIs that were sensitive to all six tested antibiotics (ampicillin, trimethoprim, amoxicillin/clavulanic acid, cefalexin, ciprofloxacin and nitrofurantoin) with regard to re-consultations and antibiotics prescribed. There were significantly higher antibiotic costs (mean extra antibiotic cost 1.19 pounds/1.75 euros), re-consultation costs ( 2.42 pounds/3.55 euros) and total costs ( 3.62 pounds/5.31euros) for patients whose infections were resistant to at least one antibiotic compared with those with sensitive infections even after accounting for potentially confounding factors. Although these per-patient costs may appear small, they do not take into account the full additional costs of resistant UTIs in the community and, given the high prevalence of UTIs, the overall costs to the health service are substantial.
published_date 2009-03-31T03:24:40Z
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score 11.012678

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