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3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications

Adam Rees, Lydia C. Powell, Gary Chinga-Carrasco, David Gethin Orcid Logo, Kristin Syverud, Katja E. Hill, David W. Thomas

BioMed Research International, Volume: 2015, Pages: 1 - 7

Swansea University Author: David Gethin Orcid Logo

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DOI (Published version): 10.1155/2015/925757

Abstract

Nanocellulose has a variety of advantages, which make the material most suitable for use in biomedical devices such as wound dressings. The material is strong, allows for production of transparent films, provides a moist wound healing environment, and can form elastic gels with bioresponsive charact...

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Published in: BioMed Research International
ISSN: 2314-6133
Published: 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa22361
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first_indexed 2015-07-17T02:04:08Z
last_indexed 2019-09-27T19:27:26Z
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spelling 2019-09-27T15:42:16.0549925 v2 22361 2015-07-16 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications 20b93675a5457203ae87ebc32bd6d155 0000-0002-7142-8253 David Gethin David Gethin true false 2015-07-16 MECH Nanocellulose has a variety of advantages, which make the material most suitable for use in biomedical devices such as wound dressings. The material is strong, allows for production of transparent films, provides a moist wound healing environment, and can form elastic gels with bioresponsive characteristics. In this study, we explore the application of nanocellulose as a bioink for modifying film surfaces by a bioprinting process. Two different nanocelluloses were used, prepared with TEMPO mediated oxidation and a combination of carboxymethylation and periodate oxidation. The combination of carboxymethylation and periodate oxidation produced a homogeneous material with short nanofibrils, having widths &#60;20 nm and lengths &#60;200 nm. The small dimensions of the nanofibrils reduced the viscosity of the nanocellulose, thus yielding a material with good rheological properties for use as a bioink. The nanocellulose bioink was thus used for printing 3D porous structures, which is exemplified in this study. We also demonstrated that both nanocelluloses did not support bacterial growth, which is an interesting property of these novel materials. Journal Article BioMed Research International 2015 1 7 2314-6133 31 12 2015 2015-12-31 10.1155/2015/925757 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2019-09-27T15:42:16.0549925 2015-07-16T13:21:50.2254178 Adam Rees 1 Lydia C. Powell 2 Gary Chinga-Carrasco 3 David Gethin 0000-0002-7142-8253 4 Kristin Syverud 5 Katja E. Hill 6 David W. Thomas 7
title 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications
spellingShingle 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications
David Gethin
title_short 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications
title_full 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications
title_fullStr 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications
title_full_unstemmed 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications
title_sort 3D Bioprinting of Carboxymethylated-Periodate Oxidized Nanocellulose Constructs for Wound Dressing Applications
author_id_str_mv 20b93675a5457203ae87ebc32bd6d155
author_id_fullname_str_mv 20b93675a5457203ae87ebc32bd6d155_***_David Gethin
author David Gethin
author2 Adam Rees
Lydia C. Powell
Gary Chinga-Carrasco
David Gethin
Kristin Syverud
Katja E. Hill
David W. Thomas
format Journal article
container_title BioMed Research International
container_volume 2015
container_start_page 1
publishDate 2015
institution Swansea University
issn 2314-6133
doi_str_mv 10.1155/2015/925757
document_store_str 0
active_str 0
description Nanocellulose has a variety of advantages, which make the material most suitable for use in biomedical devices such as wound dressings. The material is strong, allows for production of transparent films, provides a moist wound healing environment, and can form elastic gels with bioresponsive characteristics. In this study, we explore the application of nanocellulose as a bioink for modifying film surfaces by a bioprinting process. Two different nanocelluloses were used, prepared with TEMPO mediated oxidation and a combination of carboxymethylation and periodate oxidation. The combination of carboxymethylation and periodate oxidation produced a homogeneous material with short nanofibrils, having widths &#60;20 nm and lengths &#60;200 nm. The small dimensions of the nanofibrils reduced the viscosity of the nanocellulose, thus yielding a material with good rheological properties for use as a bioink. The nanocellulose bioink was thus used for printing 3D porous structures, which is exemplified in this study. We also demonstrated that both nanocelluloses did not support bacterial growth, which is an interesting property of these novel materials.
published_date 2015-12-31T03:32:55Z
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score 10.899731