Journal article 653 views
SPH simulations of WBC adhesion to the endothelium: the role of haemodynamics and endothelial binding kinetics
Biomechanics and Modeling in Mechanobiology, Volume: 14, Issue: 6, Pages: 1317 - 1333
Swansea University Author: Marco Ellero
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DOI (Published version): 10.1007/s10237-015-0676-y
Abstract
A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor–ligand adhesion behaviour to cover full cell interactions in the v...
| Published in: | Biomechanics and Modeling in Mechanobiology |
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| ISSN: | 1617-7959 1617-7940 |
| Published: |
2015
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa25441 |
| Abstract: |
A multiscale Lagrangian particle solver introduced in our previous work is extended to model physiologically realistic near-wall cell dynamics. Three-dimensional simulation of particle trajectories is combined with realistic receptor–ligand adhesion behaviour to cover full cell interactions in the vicinity of the endothelium. The selected stochastic adhesion model, which is based on a Monte Carlo acceptance–rejection method, fits in our Lagrangian framework and does not compromise performance. Additionally, appropriate inflow/outflow boundary conditions are implemented for our SPH solver to enable realistic pulsatile flow simulation. The model is tested against in-vitro data from a 3D geometry with a stenosis and sudden expansion. In both steady and pulsatile flow conditions, results show close agreement with the experimental ones. Furthermore we demonstrate, in agreement with experimental observations, that haemodynamics alone does not account for adhesion of white blood cells, in this case U937 monocytic human cells. Our findings suggest that the current framework is fully capable of modelling cell dynamics in large arteries in a realistic and efficient manner. |
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| Keywords: |
Smoothed particle hydrodynamics; Cell adhesion; White blood cells; Large artery; |
| College: |
Faculty of Science and Engineering |
| Issue: |
6 |
| Start Page: |
1317 |
| End Page: |
1333 |