No Cover Image

Journal article 751 views 141 downloads

Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs

Hemmen Sabir, Thomas Wood, Hannah Gill, Xun Liu, John Dingley, Marianne Thoresen

Journal of the Neurological Sciences, Volume: 363, Pages: 140 - 144

Swansea University Author: John Dingley

  • 1-s2.0-S0022510X16301162-main.pdf

    PDF | Accepted Manuscript

    © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

    Download (871.04KB)

Check full text

DOI (Published version): 10.1016/j.jns.2016.02.051

Abstract

Changes in electroencephalography (EEG) voltage range are used to monitor the depth of anaesthesia, as well as predict outcome after hypoxia-ischaemia in neonates. Xenon is being investigated as a potential neuroprotectant after hypoxic-ischaemic brain injury, but the effect of Xenon on EEG paramete...

Full description

Published in: Journal of the Neurological Sciences
ISSN: 0022510X
Published: 2016
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa26998
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2016-04-01T01:04:30Z
last_indexed 2019-08-12T20:16:46Z
id cronfa26998
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-08-12T15:14:21.3089954</datestamp><bib-version>v2</bib-version><id>26998</id><entry>2016-03-31</entry><title>Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs</title><swanseaauthors><author><sid>1283ffdd09b091ec57ec3e235a48cfcc</sid><firstname>John</firstname><surname>Dingley</surname><name>John Dingley</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2016-03-31</date><deptcode>PMSC</deptcode><abstract>Changes in electroencephalography (EEG) voltage range are used to monitor the depth of anaesthesia, as well as predict outcome after hypoxia-ischaemia in neonates. Xenon is being investigated as a potential neuroprotectant after hypoxic-ischaemic brain injury, but the effect of Xenon on EEG parameters in children or neonates is not known. This study aimed to examine the effect of 50% inhaled Xenon on background amplitude-integrated EEG (aEEG) activity in sedated healthy newborn pigs.Five healthy newborn pigs, receiving intravenous fentanyl sedation, were ventilated for 24 h with 50%Xenon, 30%O2 and 20%N2 at normothermia. The upper and lower voltage-range of the aEEG was continuously monitored together with cardiovascular parameters throughout a 1 h baseline period with fentanyl sedation only, followed by 24 h of Xenon administration.The median (IQR) upper and lower aEEG voltage during 1 h baseline was 48.0 &#x3BC;V (46.0-50.0) and 25.0 &#x3BC;V (23.0-26.0), respectively. The median (IQR) aEEG upper and lower voltage ranges were significantly depressed to 21.5 &#x3BC;V (20.0-26.5) and 12.0 &#x3BC;V (12.0-16.5) from 10 min after the onset of 50% Xenon administration (p=0.002). After the initial Xenon induced depression in background aEEG voltage, no further aEEG changes were seen over the following 24h of ventilation with 50% xenon under fentanyl sedation. Mean arterial blood pressure and heart rate remained stable.Mean arterial blood pressure and heart rate were not significantly influenced by 24h Xenon ventilation. 50% Xenon rapidly depresses background aEEG voltage to a steady ~50% lower level in sedated healthy newborn pigs. Therefore, care must be taken when interpreting the background voltage in neonates also receiving Xenon.</abstract><type>Journal Article</type><journal>Journal of the Neurological Sciences</journal><volume>363</volume><paginationStart>140</paginationStart><paginationEnd>144</paginationEnd><publisher/><issnPrint>0022510X</issnPrint><keywords>Amplitude-integrated encephalography; Inhalation anaesthetics; Newborn; Xenon</keywords><publishedDay>15</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2016</publishedYear><publishedDate>2016-04-15</publishedDate><doi>10.1016/j.jns.2016.02.051</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PMSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-08-12T15:14:21.3089954</lastEdited><Created>2016-03-31T14:12:47.2341223</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Hemmen</firstname><surname>Sabir</surname><order>1</order></author><author><firstname>Thomas</firstname><surname>Wood</surname><order>2</order></author><author><firstname>Hannah</firstname><surname>Gill</surname><order>3</order></author><author><firstname>Xun</firstname><surname>Liu</surname><order>4</order></author><author><firstname>John</firstname><surname>Dingley</surname><order>5</order></author><author><firstname>Marianne</firstname><surname>Thoresen</surname><order>6</order></author></authors><documents><document><filename>0026998-31032016141258.pdf</filename><originalFilename>1-s2.0-S0022510X16301162-main.pdf</originalFilename><uploaded>2016-03-31T14:12:58.6700000</uploaded><type>Output</type><contentLength>868643</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2017-02-21T00:00:00.0000000</embargoDate><documentNotes>&#xA9; 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/</documentNotes><copyrightCorrect>true</copyrightCorrect></document></documents><OutputDurs/></rfc1807>
spelling 2019-08-12T15:14:21.3089954 v2 26998 2016-03-31 Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs 1283ffdd09b091ec57ec3e235a48cfcc John Dingley John Dingley true false 2016-03-31 PMSC Changes in electroencephalography (EEG) voltage range are used to monitor the depth of anaesthesia, as well as predict outcome after hypoxia-ischaemia in neonates. Xenon is being investigated as a potential neuroprotectant after hypoxic-ischaemic brain injury, but the effect of Xenon on EEG parameters in children or neonates is not known. This study aimed to examine the effect of 50% inhaled Xenon on background amplitude-integrated EEG (aEEG) activity in sedated healthy newborn pigs.Five healthy newborn pigs, receiving intravenous fentanyl sedation, were ventilated for 24 h with 50%Xenon, 30%O2 and 20%N2 at normothermia. The upper and lower voltage-range of the aEEG was continuously monitored together with cardiovascular parameters throughout a 1 h baseline period with fentanyl sedation only, followed by 24 h of Xenon administration.The median (IQR) upper and lower aEEG voltage during 1 h baseline was 48.0 μV (46.0-50.0) and 25.0 μV (23.0-26.0), respectively. The median (IQR) aEEG upper and lower voltage ranges were significantly depressed to 21.5 μV (20.0-26.5) and 12.0 μV (12.0-16.5) from 10 min after the onset of 50% Xenon administration (p=0.002). After the initial Xenon induced depression in background aEEG voltage, no further aEEG changes were seen over the following 24h of ventilation with 50% xenon under fentanyl sedation. Mean arterial blood pressure and heart rate remained stable.Mean arterial blood pressure and heart rate were not significantly influenced by 24h Xenon ventilation. 50% Xenon rapidly depresses background aEEG voltage to a steady ~50% lower level in sedated healthy newborn pigs. Therefore, care must be taken when interpreting the background voltage in neonates also receiving Xenon. Journal Article Journal of the Neurological Sciences 363 140 144 0022510X Amplitude-integrated encephalography; Inhalation anaesthetics; Newborn; Xenon 15 4 2016 2016-04-15 10.1016/j.jns.2016.02.051 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2019-08-12T15:14:21.3089954 2016-03-31T14:12:47.2341223 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Hemmen Sabir 1 Thomas Wood 2 Hannah Gill 3 Xun Liu 4 John Dingley 5 Marianne Thoresen 6 0026998-31032016141258.pdf 1-s2.0-S0022510X16301162-main.pdf 2016-03-31T14:12:58.6700000 Output 868643 application/pdf Accepted Manuscript true 2017-02-21T00:00:00.0000000 © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ true
title Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs
spellingShingle Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs
John Dingley
title_short Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs
title_full Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs
title_fullStr Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs
title_full_unstemmed Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs
title_sort Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs
author_id_str_mv 1283ffdd09b091ec57ec3e235a48cfcc
author_id_fullname_str_mv 1283ffdd09b091ec57ec3e235a48cfcc_***_John Dingley
author John Dingley
author2 Hemmen Sabir
Thomas Wood
Hannah Gill
Xun Liu
John Dingley
Marianne Thoresen
format Journal article
container_title Journal of the Neurological Sciences
container_volume 363
container_start_page 140
publishDate 2016
institution Swansea University
issn 0022510X
doi_str_mv 10.1016/j.jns.2016.02.051
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Changes in electroencephalography (EEG) voltage range are used to monitor the depth of anaesthesia, as well as predict outcome after hypoxia-ischaemia in neonates. Xenon is being investigated as a potential neuroprotectant after hypoxic-ischaemic brain injury, but the effect of Xenon on EEG parameters in children or neonates is not known. This study aimed to examine the effect of 50% inhaled Xenon on background amplitude-integrated EEG (aEEG) activity in sedated healthy newborn pigs.Five healthy newborn pigs, receiving intravenous fentanyl sedation, were ventilated for 24 h with 50%Xenon, 30%O2 and 20%N2 at normothermia. The upper and lower voltage-range of the aEEG was continuously monitored together with cardiovascular parameters throughout a 1 h baseline period with fentanyl sedation only, followed by 24 h of Xenon administration.The median (IQR) upper and lower aEEG voltage during 1 h baseline was 48.0 μV (46.0-50.0) and 25.0 μV (23.0-26.0), respectively. The median (IQR) aEEG upper and lower voltage ranges were significantly depressed to 21.5 μV (20.0-26.5) and 12.0 μV (12.0-16.5) from 10 min after the onset of 50% Xenon administration (p=0.002). After the initial Xenon induced depression in background aEEG voltage, no further aEEG changes were seen over the following 24h of ventilation with 50% xenon under fentanyl sedation. Mean arterial blood pressure and heart rate remained stable.Mean arterial blood pressure and heart rate were not significantly influenced by 24h Xenon ventilation. 50% Xenon rapidly depresses background aEEG voltage to a steady ~50% lower level in sedated healthy newborn pigs. Therefore, care must be taken when interpreting the background voltage in neonates also receiving Xenon.
published_date 2016-04-15T03:32:37Z
_version_ 1763751344306388992
score 11.012678

Similar Items