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A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

Matthew Lawrence, Ahmed Sabra, Gavin Mills, Suresh G. Pillai, Wendy Abdullah, Karl Hawkins Orcid Logo, Roger H. K. Morris, Simon J. Davidson, Lindsay D´Silva, Daniel Curtis Orcid Logo, Rowan Brown Orcid Logo, John W. Weisel, Rhodri Williams Orcid Logo, Adrian Evans Orcid Logo

British Journal of Haematology, Volume: 168, Issue: 4, Pages: 571 - 575

Swansea University Authors: Matthew Lawrence, Ahmed Sabra, Karl Hawkins Orcid Logo, Lindsay D´Silva, Daniel Curtis Orcid Logo, Rowan Brown Orcid Logo, Rhodri Williams Orcid Logo, Adrian Evans Orcid Logo

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DOI (Published version): 10.1111/bjh.13173

Abstract

This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘a...

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Published in: British Journal of Haematology
ISSN: 0007-1048
Published: Wiley 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa27555
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Abstract: This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.
College: Swansea University Medical School
Issue: 4
Start Page: 571
End Page: 575