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A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism / Matthew Lawrence; Ahmed Sabra; Gavin Mills; Suresh G. Pillai; Wendy Abdullah; Karl Hawkins; Roger H. K. Morris; Simon J. Davidson; Lindsay A. D'Silva; Daniel Curtis; Rowan Brown; John W. Weisel; Rhodri Williams; Adrian Evans
British Journal of Haematology, Volume: 168, Issue: 4, Pages: 571 - 575
Swansea University Authors: Matthew, Lawrence, Karl, Hawkins, Daniel, Curtis, Rowan, Brown, Rhodri, Williams, Adrian, Evans
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DOI (Published version): 10.1111/bjh.13173
Abstract
This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘a...
| Published in: | British Journal of Haematology |
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| ISSN: | 0007-1048 |
| Published: |
Wiley
2015
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa27555 |
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| Abstract: |
This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence. |
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| College: |
College of Engineering |
| Issue: |
4 |
| Start Page: |
571 |
| End Page: |
575 |