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A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism / Matthew Lawrence; Ahmed Sabra; Gavin Mills; Suresh G. Pillai; Wendy Abdullah; Karl Hawkins; Roger H. K. Morris; Simon J. Davidson; Lindsay A. D'Silva; Daniel Curtis; Rowan Brown; John W. Weisel; Rhodri Williams; Adrian Evans

British Journal of Haematology, Volume: 168, Issue: 4, Pages: 571 - 575

Swansea University Authors: Matthew, Lawrence, Karl, Hawkins, Daniel, Curtis, Rowan, Brown, Rhodri, Williams, Adrian, Evans

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DOI (Published version): 10.1111/bjh.13173

Abstract

This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘a...

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Published in: British Journal of Haematology
ISSN: 0007-1048
Published: Wiley 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa27555
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Abstract: This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.
College: College of Engineering
Issue: 4
Start Page: 571
End Page: 575