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A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism / Rhodri, Williams; Karl, Hawkins; Rowan, Brown; Matthew, Lawrence; Daniel, Curtis; Adrian, Evans

British Journal of Haematology, Volume: 168, Issue: 4, Pages: 571 - 575

Swansesa University Authors: Rhodri, Williams, Karl, Hawkins, Rowan, Brown, Matthew, Lawrence, Daniel, Curtis, Adrian, Evans

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DOI (Published version): 10.1111/bjh.13173

Abstract

This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). Th...

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Published in: British Journal of Haematology
ISSN: 0007-1048
Published: Wiley 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa27555
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Abstract: This study compared patients with venous thromboembolism (VTE) to non‐VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non‐VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.
Issue: 4
Start Page: 571
End Page: 575