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Role of the inter-protofilament sliding in the bending of protein microtubules

Chengyuan Wang, Zhigang Guo, Ruijie Wang, Ying Luo

Journal of Biomechanics, Volume: 49, Issue: 16, Pages: 3803 - 3807

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Abstract

This paper aims to identify the role of the inter-protofilament (PF) sliding in the bending of microtubules (MTs). A molecular structural model (MSM) was employed to study the dependence of bending on the inter-PF bonds. It was found that the inter-PF bonds serve as an angle spring that controls the...

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Published in: Journal of Biomechanics
ISSN: 0021-9290
Published: 2016
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa30719
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Abstract: This paper aims to identify the role of the inter-protofilament (PF) sliding in the bending of microtubules (MTs). A molecular structural model (MSM) was employed to study the dependence of bending on the inter-PF bonds. It was found that the inter-PF bonds serve as an angle spring that controls the inter-PF sliding during the bending. When the angle spring is soft inter-PF sliding occurs leading to the length-dependent bending stiffness of MTs. Such a size dependent bending stiffness may also affect the vibration and buckling behavior of MTs where bending deformation is predominant.
College: College of Engineering
Issue: 16
Start Page: 3803
End Page: 3807