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Cholesterolomics: An update

William Griffiths Orcid Logo, Jonas Abdel-Khalik, Eylan Yutuc Orcid Logo, Alwena Morgan Orcid Logo, Ian Gilmore, Thomas Hearn, Yuqin Wang

Analytical Biochemistry

Swansea University Authors: William Griffiths Orcid Logo, Eylan Yutuc Orcid Logo, Alwena Morgan Orcid Logo

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DOI (Published version): 10.1016/j.ab.2017.01.009

Abstract

Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample. These molecules include 1,25-dihydroxyvitamin D3, steroid hormones and bile acids and intermediates in...

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Published in: Analytical Biochemistry
ISSN: 00032697
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa31729
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first_indexed 2017-01-24T14:48:47Z
last_indexed 2018-02-09T05:18:53Z
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spelling 2018-01-11T10:30:15.4514295 v2 31729 2017-01-24 Cholesterolomics: An update 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 99332f073ce913a9b7d8b6441b17516d 0000-0001-9971-1950 Eylan Yutuc Eylan Yutuc true false 9ea39c3d0935c897cb9fcd3ba550af71 0000-0002-3441-5357 Alwena Morgan Alwena Morgan true false 2017-01-24 BMS Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample. These molecules include 1,25-dihydroxyvitamin D3, steroid hormones and bile acids and intermediates in their respective biosynthetic pathways. In this short article we will concentrate our attention on intermediates in bile acid biosynthesis pathways, in particular oxysterols and cholestenoic acids. These molecular classes are implicated in the aetiology of a diverse array of diseases including autoimmune disease, Parkinson's disease, motor neuron disease, breast cancer, the lysosomal storage disease Niemann-Pick type C and the autosomal recessive disorder Smith-Lemli-Opitz syndrome. Mass spectrometry (MS) is the dominant technology for sterol analysis including both gas-chromatography (GC)-MS and liquid chromatography (LC)-MS and more recently matrix-assisted laser desorption/ionisation (MALDI)-MS for tissue imaging studies. Here we will discuss exciting biological findings and recent analytical improvements. Journal Article Analytical Biochemistry 00032697 Cholesterol; Oxysterols; Cholestenoic acids; Derivatisation; Mass spectrometry 31 12 2017 2017-12-31 10.1016/j.ab.2017.01.009 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University RCUK, BB/I001735/1 2018-01-11T10:30:15.4514295 2017-01-24T09:54:20.2325776 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Griffiths 0000-0002-4129-6616 1 Jonas Abdel-Khalik 2 Eylan Yutuc 0000-0001-9971-1950 3 Alwena Morgan 0000-0002-3441-5357 4 Ian Gilmore 5 Thomas Hearn 6 Yuqin Wang 7 0031729-11012018102853.pdf APCCD29.1-s2.0-S0003269717300209-main.pdf 2018-01-11T10:28:53.7870000 Output 890304 application/pdf Version of Record true 2018-01-11T00:00:00.0000000 Open Access funded by Biotechnology and Biological Sciences Research Council. Published under a Creative Commons CC-BY 4.0 License. true eng
title Cholesterolomics: An update
spellingShingle Cholesterolomics: An update
William Griffiths
Eylan Yutuc
Alwena Morgan
title_short Cholesterolomics: An update
title_full Cholesterolomics: An update
title_fullStr Cholesterolomics: An update
title_full_unstemmed Cholesterolomics: An update
title_sort Cholesterolomics: An update
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
99332f073ce913a9b7d8b6441b17516d
9ea39c3d0935c897cb9fcd3ba550af71
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
99332f073ce913a9b7d8b6441b17516d_***_Eylan Yutuc
9ea39c3d0935c897cb9fcd3ba550af71_***_Alwena Morgan
author William Griffiths
Eylan Yutuc
Alwena Morgan
author2 William Griffiths
Jonas Abdel-Khalik
Eylan Yutuc
Alwena Morgan
Ian Gilmore
Thomas Hearn
Yuqin Wang
format Journal article
container_title Analytical Biochemistry
publishDate 2017
institution Swansea University
issn 00032697
doi_str_mv 10.1016/j.ab.2017.01.009
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample. These molecules include 1,25-dihydroxyvitamin D3, steroid hormones and bile acids and intermediates in their respective biosynthetic pathways. In this short article we will concentrate our attention on intermediates in bile acid biosynthesis pathways, in particular oxysterols and cholestenoic acids. These molecular classes are implicated in the aetiology of a diverse array of diseases including autoimmune disease, Parkinson's disease, motor neuron disease, breast cancer, the lysosomal storage disease Niemann-Pick type C and the autosomal recessive disorder Smith-Lemli-Opitz syndrome. Mass spectrometry (MS) is the dominant technology for sterol analysis including both gas-chromatography (GC)-MS and liquid chromatography (LC)-MS and more recently matrix-assisted laser desorption/ionisation (MALDI)-MS for tissue imaging studies. Here we will discuss exciting biological findings and recent analytical improvements.
published_date 2017-12-31T03:38:45Z
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