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Chromophores in operative surgery: Current practice and rationalized development

Ernest Azzopardi, Sian-eleri Owens Orcid Logo, Maxwell Murison, Daniel Rees Orcid Logo, M. Anne Sawhney, L. Francis, R. Sofia Rodrigues Texeira, Marc Clement, R. Steven Conlan, Iain Whitaker, Steve Conlan Orcid Logo

Journal of Controlled Release

Swansea University Authors: Sian-eleri Owens Orcid Logo, Daniel Rees Orcid Logo, Steve Conlan Orcid Logo

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DOI (Published version): 10.1016/j.jconrel.2016.12.044

Abstract

BackgroundChromophore-containing molecules feature extensively in surgical practice, with synthetic dyes gaining popularity over endogenous optical adjuncts. New applications for chromophores in diagnostics and operative treatment exploit unique chemical structures suited for illuminating target tis...

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Published in: Journal of Controlled Release
ISSN: 0168-3659
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa31730
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first_indexed 2017-01-24T14:48:47Z
last_indexed 2023-02-03T03:38:43Z
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New applications for chromophores in diagnostics and operative treatment exploit unique chemical structures suited for illuminating target tissues beyond the visual spectrum, ranging from ultraviolet (UV) to near-infrared (NIR). This review outlines the rationale for surgical chromophore application, the weaknesses and risks in each class of these compounds, and areas of foreseeable potential for employment of specialized contrast agents.MethodAn English-language literature search applied the following Boolean Search String: &#x201C;dye OR Lake OR Stain OR chromophore&#x201D; AND &#x201C;tox$ OR terato* OR carcino$ OR Allerg$ OR surg$ OR clinic&#x201D; using EMBASE, PUBMED, PUBMED central and OVIDSp, with back-referencing through Web of Knowledge&#x2122;.ResultsBased on the primary literature, this study proposes a surgically relevant classification system of chromophores in current use, which facilitates risk/benefit consideration for the surgeon who employs them, and which facilitates clinically oriented development.ConclusionsThe next stage of development for optically active surgical adjuncts must address practical constraints whilst minimizing risks of adverse effects. 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spelling 2023-02-02T16:09:05.2824123 v2 31730 2017-01-24 Chromophores in operative surgery: Current practice and rationalized development 721deb4604d122019244cfdf08820cbe 0000-0003-1806-5235 Sian-eleri Owens Sian-eleri Owens true false daa6762111f9ebf62b9c2ec655512783 0000-0003-0372-6096 Daniel Rees Daniel Rees true false 0bb6bd247e32fb4249de62c0013b51cb 0000-0002-2562-3461 Steve Conlan Steve Conlan true false 2017-01-24 BMS BackgroundChromophore-containing molecules feature extensively in surgical practice, with synthetic dyes gaining popularity over endogenous optical adjuncts. New applications for chromophores in diagnostics and operative treatment exploit unique chemical structures suited for illuminating target tissues beyond the visual spectrum, ranging from ultraviolet (UV) to near-infrared (NIR). This review outlines the rationale for surgical chromophore application, the weaknesses and risks in each class of these compounds, and areas of foreseeable potential for employment of specialized contrast agents.MethodAn English-language literature search applied the following Boolean Search String: “dye OR Lake OR Stain OR chromophore” AND “tox$ OR terato* OR carcino$ OR Allerg$ OR surg$ OR clinic” using EMBASE, PUBMED, PUBMED central and OVIDSp, with back-referencing through Web of Knowledge™.ResultsBased on the primary literature, this study proposes a surgically relevant classification system of chromophores in current use, which facilitates risk/benefit consideration for the surgeon who employs them, and which facilitates clinically oriented development.ConclusionsThe next stage of development for optically active surgical adjuncts must address practical constraints whilst minimizing risks of adverse effects. Exploiting the technology's full potential also requires improvements in the usefulness of imagery equipment. Journal Article Journal of Controlled Release 0168-3659 Chromophore; Stain; Dye; Pigment; Lake; Contrast agent; Fluorophore; Optical adjunct; Ultraviolet; Infrared; Methylene blue; Patent Blue V; Bonney&apos;s blue; Indocyanine green; Porphyrin; Melanin; Triarylmethane; Triphenylmethane; Azo derivative; Trypan blue; Phenothiazine; Cyanine; Indigoid; Indigo carmine 31 12 2017 2017-12-31 10.1016/j.jconrel.2016.12.044 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2023-02-02T16:09:05.2824123 2017-01-24T09:54:49.3426624 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Ernest Azzopardi 1 Sian-eleri Owens 0000-0003-1806-5235 2 Maxwell Murison 3 Daniel Rees 0000-0003-0372-6096 4 M. Anne Sawhney 5 L. Francis 6 R. Sofia Rodrigues Texeira 7 Marc Clement 8 R. Steven Conlan 9 Iain Whitaker 10 Steve Conlan 0000-0002-2562-3461 11 0031730-24012017095707.pdf azzopardi2017.pdf 2017-01-24T09:57:07.6400000 Output 862328 application/pdf Accepted Manuscript true 2018-01-23T00:00:00.0000000 false
title Chromophores in operative surgery: Current practice and rationalized development
spellingShingle Chromophores in operative surgery: Current practice and rationalized development
Sian-eleri Owens
Daniel Rees
Steve Conlan
title_short Chromophores in operative surgery: Current practice and rationalized development
title_full Chromophores in operative surgery: Current practice and rationalized development
title_fullStr Chromophores in operative surgery: Current practice and rationalized development
title_full_unstemmed Chromophores in operative surgery: Current practice and rationalized development
title_sort Chromophores in operative surgery: Current practice and rationalized development
author_id_str_mv 721deb4604d122019244cfdf08820cbe
daa6762111f9ebf62b9c2ec655512783
0bb6bd247e32fb4249de62c0013b51cb
author_id_fullname_str_mv 721deb4604d122019244cfdf08820cbe_***_Sian-eleri Owens
daa6762111f9ebf62b9c2ec655512783_***_Daniel Rees
0bb6bd247e32fb4249de62c0013b51cb_***_Steve Conlan
author Sian-eleri Owens
Daniel Rees
Steve Conlan
author2 Ernest Azzopardi
Sian-eleri Owens
Maxwell Murison
Daniel Rees
M. Anne Sawhney
L. Francis
R. Sofia Rodrigues Texeira
Marc Clement
R. Steven Conlan
Iain Whitaker
Steve Conlan
format Journal article
container_title Journal of Controlled Release
publishDate 2017
institution Swansea University
issn 0168-3659
doi_str_mv 10.1016/j.jconrel.2016.12.044
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description BackgroundChromophore-containing molecules feature extensively in surgical practice, with synthetic dyes gaining popularity over endogenous optical adjuncts. New applications for chromophores in diagnostics and operative treatment exploit unique chemical structures suited for illuminating target tissues beyond the visual spectrum, ranging from ultraviolet (UV) to near-infrared (NIR). This review outlines the rationale for surgical chromophore application, the weaknesses and risks in each class of these compounds, and areas of foreseeable potential for employment of specialized contrast agents.MethodAn English-language literature search applied the following Boolean Search String: “dye OR Lake OR Stain OR chromophore” AND “tox$ OR terato* OR carcino$ OR Allerg$ OR surg$ OR clinic” using EMBASE, PUBMED, PUBMED central and OVIDSp, with back-referencing through Web of Knowledge™.ResultsBased on the primary literature, this study proposes a surgically relevant classification system of chromophores in current use, which facilitates risk/benefit consideration for the surgeon who employs them, and which facilitates clinically oriented development.ConclusionsThe next stage of development for optically active surgical adjuncts must address practical constraints whilst minimizing risks of adverse effects. Exploiting the technology's full potential also requires improvements in the usefulness of imagery equipment.
published_date 2017-12-31T03:38:45Z
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score 11.012678

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