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Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair

Christopher R. Fellows, Csaba Matta, Roza Zakany, Ilyas Khan Orcid Logo, Ali Mobasheri

Frontiers in Genetics, Volume: 7

Swansea University Author: Ilyas Khan Orcid Logo

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DOI (Published version): 10.3389/fgene.2016.00213

Abstract

Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of different...

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Published in: Frontiers in Genetics
ISSN: 1664-8021
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa31769
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first_indexed 2017-01-26T14:45:29Z
last_indexed 2018-02-09T05:18:58Z
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spelling 2017-02-15T13:08:07.4874894 v2 31769 2017-01-26 Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair 2536d955ff70e7b77063a8efe9103161 0000-0002-3886-1987 Ilyas Khan Ilyas Khan true false 2017-01-26 BMS Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of differentiating into multiple cell lineages and exerting paracrine effects. Due to their easy isolation, expansion, and low immunogenicity, MSCs are an attractive option for regenerative medicine for joint repair. Recent studies have identified several MSC tissue reservoirs including in adipose tissue, bone marrow, cartilage, periosteum, and muscle. MSCs isolated from these discrete tissue niches exhibit distinct biological activities, and have enhanced regenerative potentials for different tissue types. Each MSC type has advantages and disadvantages for cartilage repair and their use in a clinical setting is a balance between expediency and effectiveness. In this review we explore the challenges associated with cartilage repair and regeneration using MSC-based cell therapies and provide an overview of phenotype, biological activities, and functional properties for each MSC population. This paper also specifically explores the therapeutic potential of each type of MSC, particularly focusing on which cells are capable of producing stratified hyaline-like articular cartilage regeneration. Finally we highlight areas for future investigation. Given that patients present with a variety of problems it is unlikely that cartilage regeneration will be a simple “one size fits all,” but more likely an array of solutions that need to be applied systematically to achieve regeneration of a biomechanically competent repair tissue. Journal Article Frontiers in Genetics 7 1664-8021 20 12 2016 2016-12-20 10.3389/fgene.2016.00213 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2017-02-15T13:08:07.4874894 2017-01-26T11:55:57.5459108 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Christopher R. Fellows 1 Csaba Matta 2 Roza Zakany 3 Ilyas Khan 0000-0002-3886-1987 4 Ali Mobasheri 5 0031769-15022017130526.pdf fgene.pdf 2017-02-15T13:05:26.6500000 Output 2506369 application/pdf Version of Record true 2016-12-20T00:00:00.0000000 This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) true eng
title Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair
spellingShingle Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair
Ilyas Khan
title_short Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair
title_full Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair
title_fullStr Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair
title_full_unstemmed Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair
title_sort Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair
author_id_str_mv 2536d955ff70e7b77063a8efe9103161
author_id_fullname_str_mv 2536d955ff70e7b77063a8efe9103161_***_Ilyas Khan
author Ilyas Khan
author2 Christopher R. Fellows
Csaba Matta
Roza Zakany
Ilyas Khan
Ali Mobasheri
format Journal article
container_title Frontiers in Genetics
container_volume 7
publishDate 2016
institution Swansea University
issn 1664-8021
doi_str_mv 10.3389/fgene.2016.00213
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of differentiating into multiple cell lineages and exerting paracrine effects. Due to their easy isolation, expansion, and low immunogenicity, MSCs are an attractive option for regenerative medicine for joint repair. Recent studies have identified several MSC tissue reservoirs including in adipose tissue, bone marrow, cartilage, periosteum, and muscle. MSCs isolated from these discrete tissue niches exhibit distinct biological activities, and have enhanced regenerative potentials for different tissue types. Each MSC type has advantages and disadvantages for cartilage repair and their use in a clinical setting is a balance between expediency and effectiveness. In this review we explore the challenges associated with cartilage repair and regeneration using MSC-based cell therapies and provide an overview of phenotype, biological activities, and functional properties for each MSC population. This paper also specifically explores the therapeutic potential of each type of MSC, particularly focusing on which cells are capable of producing stratified hyaline-like articular cartilage regeneration. Finally we highlight areas for future investigation. Given that patients present with a variety of problems it is unlikely that cartilage regeneration will be a simple “one size fits all,” but more likely an array of solutions that need to be applied systematically to achieve regeneration of a biomechanically competent repair tissue.
published_date 2016-12-20T03:38:49Z
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