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Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins
,
Elvire Berthenet,
Samuel K. Sheppard,
Matthew Hitchings ,
Francis Mégraud,
Jamuna Vadivelu,
Philippe Lehours
Scientific Reports, Volume: 7, Start page: 42471
Swansea University Authors:
Ben Pascoe , Matthew Hitchings
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DOI (Published version): 10.1038/srep42471
Abstract
We present the full genomic sequences, insertion sites and phylogenetic analysis of 28 prophages found in H. pylori isolates from patients of distinct disease types, ranging from gastritis to gastric cancer, and geographic origins, covering most continents. The gentic diversity of H pylori is known...
| Published in: | Scientific Reports |
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| ISSN: | 2045-2322 |
| Published: |
2017
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa32006 |
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| Abstract: |
We present the full genomic sequences, insertion sites and phylogenetic analysis of 28 prophages found in H. pylori isolates from patients of distinct disease types, ranging from gastritis to gastric cancer, and geographic origins, covering most continents. The gentic diversity of H pylori is known to be influenced by these genomic elements including prophages who’s geneomes range from 22.6 to 33.0 Kbp. There was a high conservation of integration site shared in over 50% of cases with greater than 40% or prophage genomes harbouring insertion sequences (IS). Furthermore prophage genomes present a robust phylogeographic pattern, revealing four distinct clusters: one African, one Asian and two European prophage populations. There was evidence of recombination within the genome of some prophages, which resulted in genome mosaics composed by different populations, which may yield additional H. pylori phenotypes. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Start Page: |
42471 |