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Suprachoroidal shunts for treatment of glaucoma

Alessandro Mauro, Mario R. Romano, Vito Romano, Perumal Nithiarasu Orcid Logo

International Journal of Numerical Methods for Heat & Fluid Flow, Volume: 28, Issue: 2, Pages: 297 - 314

Swansea University Author: Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1108/hff-12-2016-0508

Abstract

PurposeThe purpose of this paper is to compare the fluid dynamic performance of two Aqueous Humor (AH) ocular drainage devices, the SOLX® Gold Micro Shunt (GMS) and the novel Silicon Shunt Device (SSD), implanted by surgeons in human eyes to reduce the IntraOcular Pressure (IOP) towards physiologica...

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Published in: International Journal of Numerical Methods for Heat & Fluid Flow
ISSN: 0961-5539
Published: Emerald 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa32116
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spelling v2 32116 2017-02-27 Suprachoroidal shunts for treatment of glaucoma 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2017-02-27 CIVL PurposeThe purpose of this paper is to compare the fluid dynamic performance of two Aqueous Humor (AH) ocular drainage devices, the SOLX® Gold Micro Shunt (GMS) and the novel Silicon Shunt Device (SSD), implanted by surgeons in human eyes to reduce the IntraOcular Pressure (IOP) towards physiological values, by draining the AH from the Anterior Chamber (AC) to the Suprachoroidal Space (SCS), in order to cure eyes with glaucoma.Design/methodology/approachThe generalised porous medium model is solved to simulate the AH flow through the two ocular drainage devices and the surrounding porous tissues of the eye.FindingsIn the GMS, probable stagnation regions have been found, due to very small AH velocity values inside the device and to the surrounding tissues, creating possible blockage and malfunction of the device. The simple microtubular geometry of the novel SSD allows to have a regular AH flow and to choose shunts with different diameters and/or with the presence of radial holes, based on patient needs, with consequent reduction of post-operative complications.Research limitations/implicationsThe present model will be further developed taking into account the insertion of the present drainage devices inside the anterior section of the eye. The present results show the comparative fluid dynamic performance of the two shunts considered, and can be useful for surgeons in order to choose the adequate shunt, based on the required AH flow rate for a specific patient.Practical implicationsThe present numerical approach, employing the generalized porous medium model, represents a useful tool to study the fluid dynamics of ocular drainage devices and to design these shunts, in order to reduce post-operative complications.Originality/valueThe generalised porous medium model is here applied for the first time to simulate the interaction of ocular drainage devices with the surrounding porous tissues of the eye. Journal Article International Journal of Numerical Methods for Heat &amp; Fluid Flow 28 2 297 314 Emerald 0961-5539 Numerical modelling, Finite element method, Eye, Ocular Pathology, Patient specific, Surgery 5 2 2018 2018-02-05 10.1108/hff-12-2016-0508 http://dx.doi.org/10.1108/hff-12-2016-0508 COLLEGE NANME Civil Engineering COLLEGE CODE CIVL Swansea University 2023-06-02T15:00:30.7962866 2017-02-27T09:17:10.6846184 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Alessandro Mauro 1 Mario R. Romano 2 Vito Romano 3 Perumal Nithiarasu 0000-0002-4901-2980 4 0032116-27022017092428.pdf mauro2017.pdf 2017-02-27T09:24:28.9430000 Output 2142925 application/pdf Accepted Manuscript true 2018-01-08T00:00:00.0000000 false eng
title Suprachoroidal shunts for treatment of glaucoma
spellingShingle Suprachoroidal shunts for treatment of glaucoma
Perumal Nithiarasu
title_short Suprachoroidal shunts for treatment of glaucoma
title_full Suprachoroidal shunts for treatment of glaucoma
title_fullStr Suprachoroidal shunts for treatment of glaucoma
title_full_unstemmed Suprachoroidal shunts for treatment of glaucoma
title_sort Suprachoroidal shunts for treatment of glaucoma
author_id_str_mv 3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv 3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Perumal Nithiarasu
author2 Alessandro Mauro
Mario R. Romano
Vito Romano
Perumal Nithiarasu
format Journal article
container_title International Journal of Numerical Methods for Heat &amp; Fluid Flow
container_volume 28
container_issue 2
container_start_page 297
publishDate 2018
institution Swansea University
issn 0961-5539
doi_str_mv 10.1108/hff-12-2016-0508
publisher Emerald
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
url http://dx.doi.org/10.1108/hff-12-2016-0508
document_store_str 1
active_str 0
description PurposeThe purpose of this paper is to compare the fluid dynamic performance of two Aqueous Humor (AH) ocular drainage devices, the SOLX® Gold Micro Shunt (GMS) and the novel Silicon Shunt Device (SSD), implanted by surgeons in human eyes to reduce the IntraOcular Pressure (IOP) towards physiological values, by draining the AH from the Anterior Chamber (AC) to the Suprachoroidal Space (SCS), in order to cure eyes with glaucoma.Design/methodology/approachThe generalised porous medium model is solved to simulate the AH flow through the two ocular drainage devices and the surrounding porous tissues of the eye.FindingsIn the GMS, probable stagnation regions have been found, due to very small AH velocity values inside the device and to the surrounding tissues, creating possible blockage and malfunction of the device. The simple microtubular geometry of the novel SSD allows to have a regular AH flow and to choose shunts with different diameters and/or with the presence of radial holes, based on patient needs, with consequent reduction of post-operative complications.Research limitations/implicationsThe present model will be further developed taking into account the insertion of the present drainage devices inside the anterior section of the eye. The present results show the comparative fluid dynamic performance of the two shunts considered, and can be useful for surgeons in order to choose the adequate shunt, based on the required AH flow rate for a specific patient.Practical implicationsThe present numerical approach, employing the generalized porous medium model, represents a useful tool to study the fluid dynamics of ocular drainage devices and to design these shunts, in order to reduce post-operative complications.Originality/valueThe generalised porous medium model is here applied for the first time to simulate the interaction of ocular drainage devices with the surrounding porous tissues of the eye.
published_date 2018-02-05T15:00:29Z
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score 11.017797

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