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Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes

Maddalena Lettino, Pontus Andell, Uwe Zeymer, Petr Widimsky, Nicolas Danchin, Alfredo Bardaji, Jose A. Barrabes, Angel Cequier, Marc J. Claeys, Leonardo De Luca, Jakob Dörler, David Erlinge, Paul Erne, Patrick Goldstein, Sasha M. Koul, Gilles Lemesle, Thomas F. Lüscher, Christian M. Matter, Gilles Montalescot, Dragana Radovanovic, Jose Lopez Sendón, Petr Tousek, Franz Weidinger, Clive Weston Orcid Logo, Azfar Zaman, Jin Li, J. Wouter Jukema

European Heart Journal - Cardiovascular Pharmacotherapy

Swansea University Author: Clive Weston Orcid Logo

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DOI (Published version): 10.1093/ehjcvp/pvw049

Abstract

In acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at high risk of recurrent cardiovascular events and premature death. We described patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in 10...

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Published in: European Heart Journal - Cardiovascular Pharmacotherapy
ISSN: 2055-6837 2055-6845
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa32499
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In the 10 registries there were 28,899 with and 97,505 without without DM. In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 100.0% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52).</abstract><type>Journal Article</type><journal>European Heart Journal - Cardiovascular Pharmacotherapy</journal><publisher/><issnPrint>2055-6837</issnPrint><issnElectronic>2055-6845</issnElectronic><keywords>acute coronary syndrome, diabetes mellitus, Myocardial infarction, outcomes, registries,</keywords><publishedDay>10</publishedDay><publishedMonth>3</publishedMonth><publishedYear>2017</publishedYear><publishedDate>2017-03-10</publishedDate><doi>10.1093/ehjcvp/pvw049</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PMSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2018-04-19T13:30:30.4982466</lastEdited><Created>2017-03-19T18:30:59.2034693</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Maddalena</firstname><surname>Lettino</surname><order>1</order></author><author><firstname>Pontus</firstname><surname>Andell</surname><order>2</order></author><author><firstname>Uwe</firstname><surname>Zeymer</surname><order>3</order></author><author><firstname>Petr</firstname><surname>Widimsky</surname><order>4</order></author><author><firstname>Nicolas</firstname><surname>Danchin</surname><order>5</order></author><author><firstname>Alfredo</firstname><surname>Bardaji</surname><order>6</order></author><author><firstname>Jose A.</firstname><surname>Barrabes</surname><order>7</order></author><author><firstname>Angel</firstname><surname>Cequier</surname><order>8</order></author><author><firstname>Marc J.</firstname><surname>Claeys</surname><order>9</order></author><author><firstname>Leonardo</firstname><surname>De Luca</surname><order>10</order></author><author><firstname>Jakob</firstname><surname>D&#xF6;rler</surname><order>11</order></author><author><firstname>David</firstname><surname>Erlinge</surname><order>12</order></author><author><firstname>Paul</firstname><surname>Erne</surname><order>13</order></author><author><firstname>Patrick</firstname><surname>Goldstein</surname><order>14</order></author><author><firstname>Sasha M.</firstname><surname>Koul</surname><order>15</order></author><author><firstname>Gilles</firstname><surname>Lemesle</surname><order>16</order></author><author><firstname>Thomas F.</firstname><surname>L&#xFC;scher</surname><order>17</order></author><author><firstname>Christian M.</firstname><surname>Matter</surname><order>18</order></author><author><firstname>Gilles</firstname><surname>Montalescot</surname><order>19</order></author><author><firstname>Dragana</firstname><surname>Radovanovic</surname><order>20</order></author><author><firstname>Jose Lopez</firstname><surname>Send&#xF3;n</surname><order>21</order></author><author><firstname>Petr</firstname><surname>Tousek</surname><order>22</order></author><author><firstname>Franz</firstname><surname>Weidinger</surname><order>23</order></author><author><firstname>Clive</firstname><surname>Weston</surname><orcid>0000-0002-8995-8199</orcid><order>24</order></author><author><firstname>Azfar</firstname><surname>Zaman</surname><order>25</order></author><author><firstname>Jin</firstname><surname>Li</surname><order>26</order></author><author><firstname>J. 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spelling 2018-04-19T13:30:30.4982466 v2 32499 2017-03-19 Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes df85e4e0e139d0f46eb683174eba98a9 0000-0002-8995-8199 Clive Weston Clive Weston true false 2017-03-19 PMSC In acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at high risk of recurrent cardiovascular events and premature death. We described patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in 10 contemporary European registries. In the 10 registries there were 28,899 with and 97,505 without without DM. In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 100.0% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52). Journal Article European Heart Journal - Cardiovascular Pharmacotherapy 2055-6837 2055-6845 acute coronary syndrome, diabetes mellitus, Myocardial infarction, outcomes, registries, 10 3 2017 2017-03-10 10.1093/ehjcvp/pvw049 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2018-04-19T13:30:30.4982466 2017-03-19T18:30:59.2034693 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Maddalena Lettino 1 Pontus Andell 2 Uwe Zeymer 3 Petr Widimsky 4 Nicolas Danchin 5 Alfredo Bardaji 6 Jose A. Barrabes 7 Angel Cequier 8 Marc J. Claeys 9 Leonardo De Luca 10 Jakob Dörler 11 David Erlinge 12 Paul Erne 13 Patrick Goldstein 14 Sasha M. Koul 15 Gilles Lemesle 16 Thomas F. Lüscher 17 Christian M. Matter 18 Gilles Montalescot 19 Dragana Radovanovic 20 Jose Lopez Sendón 21 Petr Tousek 22 Franz Weidinger 23 Clive Weston 0000-0002-8995-8199 24 Azfar Zaman 25 Jin Li 26 J. Wouter Jukema 27 0032499-19042018132742.pdf 32499.pdf 2018-04-19T13:27:42.4370000 Output 2373923 application/pdf Accepted Manuscript true 2017-03-19T00:00:00.0000000 true eng
title Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
spellingShingle Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
Clive Weston
title_short Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
title_full Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
title_fullStr Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
title_full_unstemmed Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
title_sort Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
author_id_str_mv df85e4e0e139d0f46eb683174eba98a9
author_id_fullname_str_mv df85e4e0e139d0f46eb683174eba98a9_***_Clive Weston
author Clive Weston
author2 Maddalena Lettino
Pontus Andell
Uwe Zeymer
Petr Widimsky
Nicolas Danchin
Alfredo Bardaji
Jose A. Barrabes
Angel Cequier
Marc J. Claeys
Leonardo De Luca
Jakob Dörler
David Erlinge
Paul Erne
Patrick Goldstein
Sasha M. Koul
Gilles Lemesle
Thomas F. Lüscher
Christian M. Matter
Gilles Montalescot
Dragana Radovanovic
Jose Lopez Sendón
Petr Tousek
Franz Weidinger
Clive Weston
Azfar Zaman
Jin Li
J. Wouter Jukema
format Journal article
container_title European Heart Journal - Cardiovascular Pharmacotherapy
publishDate 2017
institution Swansea University
issn 2055-6837
2055-6845
doi_str_mv 10.1093/ehjcvp/pvw049
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description In acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at high risk of recurrent cardiovascular events and premature death. We described patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in 10 contemporary European registries. In the 10 registries there were 28,899 with and 97,505 without without DM. In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 100.0% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52).
published_date 2017-03-10T03:39:49Z
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