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Alternative Hydrogen Source for Asymmetric Transfer Hydrogenation in the Reduction of Ketones

R. Wakeham, J. Morris, J. Williams, Russell Wakeham Orcid Logo

ChemCatChem, Volume: 7, Issue: 24, Pages: 4039 - 4041

Swansea University Author: Russell Wakeham Orcid Logo

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DOI (Published version): 10.1002/cctc.201500886

Abstract

cis-1,4-Butenediol is shown to be a highly active hydrogen source for asymmetric transfer hydrogenation in the reduction of ketones. With the use of a ruthenium catalyst, cis-1,4-butenediol is isomerised and subsequently oxidised to a lactone as an irreversible step, which provides the driving force...

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Published in: ChemCatChem
ISSN: 1867-3880
Published: Wiley-Blackwell 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa32707
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Abstract: cis-1,4-Butenediol is shown to be a highly active hydrogen source for asymmetric transfer hydrogenation in the reduction of ketones. With the use of a ruthenium catalyst, cis-1,4-butenediol is isomerised and subsequently oxidised to a lactone as an irreversible step, which provides the driving force for the asymmetric reduction of ketones.
College: Faculty of Science and Engineering
Issue: 24
Start Page: 4039
End Page: 4041