Journal article 496 views
Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties
S. Rinaldi,
E. Fortunati,
M. Taddei,
J. Kenny,
I. Armentano,
L. Latterini,
Marco Taddei 
Journal of Applied Polymer Science, Volume: 130, Issue: 2, Pages: 1185 - 1193
Swansea University Author:
Marco Taddei
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1002/app.39255
Abstract
Biodegradable polymer based nanocomposite materials have attracted much attention since they can be used for biomedical and pharmaceutical applications. In order to have highly integrated PLGA nanocomposite materials, silver colloidal nanoparticles were prepared in chloroform starting from silver ni...
| Published in: | Journal of Applied Polymer Science |
|---|---|
| ISSN: | 0021-8995 |
| Published: |
Wiley-Blackwell
2013
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa32753 |
| first_indexed |
2017-03-29T13:47:16Z |
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| last_indexed |
2018-02-09T05:21:01Z |
| id |
cronfa32753 |
| recordtype |
SURis |
| fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2017-04-03T12:05:43.7505279</datestamp><bib-version>v2</bib-version><id>32753</id><entry>2017-03-29</entry><title>Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties</title><swanseaauthors><author><sid>5cffd1038508554d8596dee8b4e51052</sid><ORCID>0000-0003-2805-6375</ORCID><firstname>Marco</firstname><surname>Taddei</surname><name>Marco Taddei</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2017-03-29</date><abstract>Biodegradable polymer based nanocomposite materials have attracted much attention since they can be used for biomedical and pharmaceutical applications. In order to have highly integrated PLGA nanocomposite materials, silver colloidal nanoparticles were prepared in chloroform starting from silver nitrate and using polyvinylpyrrolidone as reduction and capping agent. TEM and AFM imaging give information on the size distribution of the silver nucleus (7.0 nm) and the capping shell (8.2–10.7 nm). PLGA–Ag nanocomposites were prepared upon addition of 1 or 3% wt of silver nanoparticles to the PLGA/chloroform suspension. The effect of silver loading on polymer degradation was studied following the mass loss and the morphology of nanocomposite films at different degradation stages. The concentrations of Ag+, which is released during nanocomposite degradation, were monitored and analyzed through the diffusion model, to have insight on the degradation kinetics. The release rate, and likely the degradation rate, was reduced at higher silver loading. Bacterial growth tests indicated that the cell growth is inhibited in the presence of PLGA–Ag nanocomposites and the efficiency is correlated to Ag+ release. Thus, controlling the nanoparticle loading, a tunable degradation and antibacterial action can be designed.</abstract><type>Journal Article</type><journal>Journal of Applied Polymer Science</journal><volume>130</volume><journalNumber>2</journalNumber><paginationStart>1185</paginationStart><paginationEnd>1193</paginationEnd><publisher>Wiley-Blackwell</publisher><issnPrint>0021-8995</issnPrint><keywords>nanoparticles; nanowires and nanocrystals; biodegradable; composites; degradation; biomedical applications</keywords><publishedDay>30</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2013</publishedYear><publishedDate>2013-04-30</publishedDate><doi>10.1002/app.39255</doi><url/><notes/><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm/><lastEdited>2017-04-03T12:05:43.7505279</lastEdited><Created>2017-03-29T09:52:46.8138081</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Uncategorised</level></path><authors><author><firstname>S.</firstname><surname>Rinaldi</surname><order>1</order></author><author><firstname>E.</firstname><surname>Fortunati</surname><order>2</order></author><author><firstname>M.</firstname><surname>Taddei</surname><order>3</order></author><author><firstname>J.</firstname><surname>Kenny</surname><order>4</order></author><author><firstname>I.</firstname><surname>Armentano</surname><order>5</order></author><author><firstname>L.</firstname><surname>Latterini</surname><order>6</order></author><author><firstname>Marco</firstname><surname>Taddei</surname><orcid>0000-0003-2805-6375</orcid><order>7</order></author></authors><documents/><OutputDurs/></rfc1807> |
| spelling |
2017-04-03T12:05:43.7505279 v2 32753 2017-03-29 Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties 5cffd1038508554d8596dee8b4e51052 0000-0003-2805-6375 Marco Taddei Marco Taddei true false 2017-03-29 Biodegradable polymer based nanocomposite materials have attracted much attention since they can be used for biomedical and pharmaceutical applications. In order to have highly integrated PLGA nanocomposite materials, silver colloidal nanoparticles were prepared in chloroform starting from silver nitrate and using polyvinylpyrrolidone as reduction and capping agent. TEM and AFM imaging give information on the size distribution of the silver nucleus (7.0 nm) and the capping shell (8.2–10.7 nm). PLGA–Ag nanocomposites were prepared upon addition of 1 or 3% wt of silver nanoparticles to the PLGA/chloroform suspension. The effect of silver loading on polymer degradation was studied following the mass loss and the morphology of nanocomposite films at different degradation stages. The concentrations of Ag+, which is released during nanocomposite degradation, were monitored and analyzed through the diffusion model, to have insight on the degradation kinetics. The release rate, and likely the degradation rate, was reduced at higher silver loading. Bacterial growth tests indicated that the cell growth is inhibited in the presence of PLGA–Ag nanocomposites and the efficiency is correlated to Ag+ release. Thus, controlling the nanoparticle loading, a tunable degradation and antibacterial action can be designed. Journal Article Journal of Applied Polymer Science 130 2 1185 1193 Wiley-Blackwell 0021-8995 nanoparticles; nanowires and nanocrystals; biodegradable; composites; degradation; biomedical applications 30 4 2013 2013-04-30 10.1002/app.39255 COLLEGE NANME COLLEGE CODE Swansea University 2017-04-03T12:05:43.7505279 2017-03-29T09:52:46.8138081 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised S. Rinaldi 1 E. Fortunati 2 M. Taddei 3 J. Kenny 4 I. Armentano 5 L. Latterini 6 Marco Taddei 0000-0003-2805-6375 7 |
| title |
Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties |
| spellingShingle |
Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties Marco Taddei |
| title_short |
Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties |
| title_full |
Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties |
| title_fullStr |
Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties |
| title_full_unstemmed |
Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties |
| title_sort |
Integrated PLGA-Ag nanocomposite systems to control the degradation rate and antibacterial properties |
| author_id_str_mv |
5cffd1038508554d8596dee8b4e51052 |
| author_id_fullname_str_mv |
5cffd1038508554d8596dee8b4e51052_***_Marco Taddei |
| author |
Marco Taddei |
| author2 |
S. Rinaldi E. Fortunati M. Taddei J. Kenny I. Armentano L. Latterini Marco Taddei |
| format |
Journal article |
| container_title |
Journal of Applied Polymer Science |
| container_volume |
130 |
| container_issue |
2 |
| container_start_page |
1185 |
| publishDate |
2013 |
| institution |
Swansea University |
| issn |
0021-8995 |
| doi_str_mv |
10.1002/app.39255 |
| publisher |
Wiley-Blackwell |
| college_str |
Faculty of Science and Engineering |
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|
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
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School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised |
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0 |
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0 |
| description |
Biodegradable polymer based nanocomposite materials have attracted much attention since they can be used for biomedical and pharmaceutical applications. In order to have highly integrated PLGA nanocomposite materials, silver colloidal nanoparticles were prepared in chloroform starting from silver nitrate and using polyvinylpyrrolidone as reduction and capping agent. TEM and AFM imaging give information on the size distribution of the silver nucleus (7.0 nm) and the capping shell (8.2–10.7 nm). PLGA–Ag nanocomposites were prepared upon addition of 1 or 3% wt of silver nanoparticles to the PLGA/chloroform suspension. The effect of silver loading on polymer degradation was studied following the mass loss and the morphology of nanocomposite films at different degradation stages. The concentrations of Ag+, which is released during nanocomposite degradation, were monitored and analyzed through the diffusion model, to have insight on the degradation kinetics. The release rate, and likely the degradation rate, was reduced at higher silver loading. Bacterial growth tests indicated that the cell growth is inhibited in the presence of PLGA–Ag nanocomposites and the efficiency is correlated to Ag+ release. Thus, controlling the nanoparticle loading, a tunable degradation and antibacterial action can be designed. |
| published_date |
2013-04-30T04:16:54Z |
| _version_ |
1864316763377762304 |
| score |
11.103853 |