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Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer

J. Brett, D. Fenlon, M. Boulton, N.J. Hulbert-Williams, F.M. Walter, P. Donnelly, B. Lavery, A. Morgan, C. Morris, E. Watson, Deborah Fenlon

European Journal of Cancer Care, Volume: 27, Issue: 1

Swansea University Author: Deborah Fenlon

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DOI (Published version): 10.1111/ecc.12601

Abstract

Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimaldespite its known efficacy in reducing recurrence and mortality. This study aims toinvestigate factors associated with non-adherence and inform the development ofinterventions to support women and promote...

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Published in: European Journal of Cancer Care
ISSN: 09615423
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa32821
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spelling 2020-10-06T12:57:57.7859617 v2 32821 2017-03-30 Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer efa6c181fe0a6e5c923b1126ce469186 Deborah Fenlon Deborah Fenlon true false 2017-03-30 FGMHL Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimaldespite its known efficacy in reducing recurrence and mortality. This study aims toinvestigate factors associated with non-adherence and inform the development ofinterventions to support women and promote adherence. A questionnaire survey to measurelevel of adherence, side effects experienced, beliefs about medicine, support received andsocio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis.Differences between non-adherers and adherers to AET were explored, and factors associatedwith intentional and unintentional non-adherence are reported. Approximately one quarter ofrespondents, 46 (22%), were non-adherers, comprising 29 (14%) intentional non-adherersand 17 (8%) unintentional non-adherers. Factors significantly associated with intentionalnon-adherence were: the presence of side effects (p<0.03), greater concerns about AET(p<0.001), and a lower perceived necessity to take AET (p<0.001). Half of the sample(105/211) reported that side effects had a moderate or high impact on their quality of life.Factors associated with unintentional non-adherence were: younger age (<65), (p<0.001),post-secondary education (p=0.046), and paid employment (p=0.031). There are distinctdifferences between intentional non-adherence and unintentional non-adherence.Differentiation between the two types of non-adherence may help tailor support and adviceinterventions Journal Article European Journal of Cancer Care 27 1 09615423 1 1 2018 2018-01-01 10.1111/ecc.12601 http://europepmc.org/abstract/med/27901302 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2020-10-06T12:57:57.7859617 2017-03-30T14:26:06.0865286 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing J. Brett 1 D. Fenlon 2 M. Boulton 3 N.J. Hulbert-Williams 4 F.M. Walter 5 P. Donnelly 6 B. Lavery 7 A. Morgan 8 C. Morris 9 E. Watson 10 Deborah Fenlon 11 0032821-30052017104018.pdf BrettFactorsAssociated2016.pdf 2017-05-30T10:40:18.2000000 Output 363338 application/pdf Accepted Manuscript true 2017-11-30T00:00:00.0000000 true eng
title Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer
spellingShingle Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer
Deborah Fenlon
title_short Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer
title_full Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer
title_fullStr Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer
title_full_unstemmed Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer
title_sort Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer
author_id_str_mv efa6c181fe0a6e5c923b1126ce469186
author_id_fullname_str_mv efa6c181fe0a6e5c923b1126ce469186_***_Deborah Fenlon
author Deborah Fenlon
author2 J. Brett
D. Fenlon
M. Boulton
N.J. Hulbert-Williams
F.M. Walter
P. Donnelly
B. Lavery
A. Morgan
C. Morris
E. Watson
Deborah Fenlon
format Journal article
container_title European Journal of Cancer Care
container_volume 27
container_issue 1
publishDate 2018
institution Swansea University
issn 09615423
doi_str_mv 10.1111/ecc.12601
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
url http://europepmc.org/abstract/med/27901302
document_store_str 1
active_str 0
description Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimaldespite its known efficacy in reducing recurrence and mortality. This study aims toinvestigate factors associated with non-adherence and inform the development ofinterventions to support women and promote adherence. A questionnaire survey to measurelevel of adherence, side effects experienced, beliefs about medicine, support received andsocio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis.Differences between non-adherers and adherers to AET were explored, and factors associatedwith intentional and unintentional non-adherence are reported. Approximately one quarter ofrespondents, 46 (22%), were non-adherers, comprising 29 (14%) intentional non-adherersand 17 (8%) unintentional non-adherers. Factors significantly associated with intentionalnon-adherence were: the presence of side effects (p<0.03), greater concerns about AET(p<0.001), and a lower perceived necessity to take AET (p<0.001). Half of the sample(105/211) reported that side effects had a moderate or high impact on their quality of life.Factors associated with unintentional non-adherence were: younger age (<65), (p<0.001),post-secondary education (p=0.046), and paid employment (p=0.031). There are distinctdifferences between intentional non-adherence and unintentional non-adherence.Differentiation between the two types of non-adherence may help tailor support and adviceinterventions
published_date 2018-01-01T03:40:20Z
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score 11.03559

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