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Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis

Melitta McNarry Orcid Logo, Nicholas K. Harrison, Tom Withers, Narendra Chinnappa, Michael Lewis

BMC Pulmonary Medicine, Volume: 17, Issue: 1

Swansea University Authors: Melitta McNarry Orcid Logo, Michael Lewis

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DOI (Published version): 10.1186/s12890-017-0364-z

Abstract

BackgroundLittle is known about the mechanistic basis for the exercise intolerance characteristic of patients with respiratory disease; a lack of clearly defined, distinct patient groups limits interpretation of many studies. The purpose of this pilot study was to investigate the pulmonary oxygen up...

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Published in: BMC Pulmonary Medicine
ISSN: 1471-2466
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa32958
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2020-06-24T11:07:32.7108362</datestamp><bib-version>v2</bib-version><id>32958</id><entry>2017-04-06</entry><title>Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis</title><swanseaauthors><author><sid>062f5697ff59f004bc8c713955988398</sid><ORCID>0000-0003-0813-7477</ORCID><firstname>Melitta</firstname><surname>McNarry</surname><name>Melitta McNarry</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>b59c8f5c056bac7e6995385f22ad1639</sid><firstname>Michael</firstname><surname>Lewis</surname><name>Michael Lewis</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2017-04-06</date><deptcode>STSC</deptcode><abstract>BackgroundLittle is known about the mechanistic basis for the exercise intolerance characteristic of patients with respiratory disease; a lack of clearly defined, distinct patient groups limits interpretation of many studies. The purpose of this pilot study was to investigate the pulmonary oxygen uptake (V.V. O2) response, and its potential determinants, in patients with emphysema and idiopathic pulmonary fibrosis (IPF).MethodsFollowing a ramp incremental test for the determination of peak V.V. O2 and the gas exchange threshold, six emphysema (66&#x2009;&#xB1;&#x2009;7 years; FEV1, 36&#x2009;&#xB1;&#x2009;16%), five IPF (65&#x2009;&#xB1;&#x2009;12 years; FEV1, 82&#x2009;&#xB1;&#x2009;11%) and ten healthy control participants (63&#x2009;&#xB1;&#x2009;6 years) completed three repeat, heavy-intensity exercise transitions on a cycle ergometer. Throughout each transition, pulmonary gas exchange, heart rate and muscle deoxygenation ([HHb], patients only) were assessed continuously and subsequently modelled using a mono-exponential with (V.V. O2, [HHb]) or without (HR) a time delay.ResultsThe V.V. O2 phase II time-constant (&#x3C4;) did not differ between IPF and emphysema, with both groups significantly slower than healthy controls (Emphysema, 65&#x2009;&#xB1;&#x2009;11; IPF, 69&#x2009;&#xB1;&#x2009;7; Control, 31&#x2009;&#xB1;&#x2009;7 s; P&#x2009;&amp;#60;&#x2009;0.05). The HR &#x3C4; was slower in emphysema relative to IPF, with both groups significantly slower than controls (Emphysema, 87&#x2009;&#xB1;&#x2009;19; IPF, 119&#x2009;&#xB1;&#x2009;20; Control, 58&#x2009;&#xB1;&#x2009;11 s; P&#x2009;&amp;#60;&#x2009;0.05). In contrast, neither the [HHb] &#x3C4; nor [HHb]:O2 ratio differed between patient groups.ConclusionsThe slower V.V. O2 kinetics in emphysema and IPF may reflect poorer matching of O2 delivery-to-utilisation. Our findings extend our understanding of the exercise dysfunction in patients with respiratory disease and may help to inform the development of appropriately targeted rehabilitation strategies.</abstract><type>Journal Article</type><journal>BMC Pulmonary Medicine</journal><volume>17</volume><journalNumber>1</journalNumber><publisher/><issnElectronic>1471-2466</issnElectronic><keywords>Respiratory disease, V.V. O2 kinetics, NIRS, Cycle</keywords><publishedDay>31</publishedDay><publishedMonth>1</publishedMonth><publishedYear>2017</publishedYear><publishedDate>2017-01-31</publishedDate><doi>10.1186/s12890-017-0364-z</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-06-24T11:07:32.7108362</lastEdited><Created>2017-04-06T09:15:47.6633647</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Uncategorised</level></path><authors><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>1</order></author><author><firstname>Nicholas K.</firstname><surname>Harrison</surname><order>2</order></author><author><firstname>Tom</firstname><surname>Withers</surname><order>3</order></author><author><firstname>Narendra</firstname><surname>Chinnappa</surname><order>4</order></author><author><firstname>Michael</firstname><surname>Lewis</surname><order>5</order></author></authors><documents><document><filename>0032958-06042017091742.pdf</filename><originalFilename>mcnarry2017.pdf</originalFilename><uploaded>2017-04-06T09:17:42.0770000</uploaded><type>Output</type><contentLength>561969</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2017-04-06T00:00:00.0000000</embargoDate><documentNotes>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2020-06-24T11:07:32.7108362 v2 32958 2017-04-06 Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false b59c8f5c056bac7e6995385f22ad1639 Michael Lewis Michael Lewis true false 2017-04-06 STSC BackgroundLittle is known about the mechanistic basis for the exercise intolerance characteristic of patients with respiratory disease; a lack of clearly defined, distinct patient groups limits interpretation of many studies. The purpose of this pilot study was to investigate the pulmonary oxygen uptake (V.V. O2) response, and its potential determinants, in patients with emphysema and idiopathic pulmonary fibrosis (IPF).MethodsFollowing a ramp incremental test for the determination of peak V.V. O2 and the gas exchange threshold, six emphysema (66 ± 7 years; FEV1, 36 ± 16%), five IPF (65 ± 12 years; FEV1, 82 ± 11%) and ten healthy control participants (63 ± 6 years) completed three repeat, heavy-intensity exercise transitions on a cycle ergometer. Throughout each transition, pulmonary gas exchange, heart rate and muscle deoxygenation ([HHb], patients only) were assessed continuously and subsequently modelled using a mono-exponential with (V.V. O2, [HHb]) or without (HR) a time delay.ResultsThe V.V. O2 phase II time-constant (τ) did not differ between IPF and emphysema, with both groups significantly slower than healthy controls (Emphysema, 65 ± 11; IPF, 69 ± 7; Control, 31 ± 7 s; P &#60; 0.05). The HR τ was slower in emphysema relative to IPF, with both groups significantly slower than controls (Emphysema, 87 ± 19; IPF, 119 ± 20; Control, 58 ± 11 s; P &#60; 0.05). In contrast, neither the [HHb] τ nor [HHb]:O2 ratio differed between patient groups.ConclusionsThe slower V.V. O2 kinetics in emphysema and IPF may reflect poorer matching of O2 delivery-to-utilisation. Our findings extend our understanding of the exercise dysfunction in patients with respiratory disease and may help to inform the development of appropriately targeted rehabilitation strategies. Journal Article BMC Pulmonary Medicine 17 1 1471-2466 Respiratory disease, V.V. O2 kinetics, NIRS, Cycle 31 1 2017 2017-01-31 10.1186/s12890-017-0364-z COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2020-06-24T11:07:32.7108362 2017-04-06T09:15:47.6633647 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Melitta McNarry 0000-0003-0813-7477 1 Nicholas K. Harrison 2 Tom Withers 3 Narendra Chinnappa 4 Michael Lewis 5 0032958-06042017091742.pdf mcnarry2017.pdf 2017-04-06T09:17:42.0770000 Output 561969 application/pdf Version of Record true 2017-04-06T00:00:00.0000000 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis
spellingShingle Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis
Melitta McNarry
Michael Lewis
title_short Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis
title_full Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis
title_fullStr Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis
title_full_unstemmed Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis
title_sort Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis
author_id_str_mv 062f5697ff59f004bc8c713955988398
b59c8f5c056bac7e6995385f22ad1639
author_id_fullname_str_mv 062f5697ff59f004bc8c713955988398_***_Melitta McNarry
b59c8f5c056bac7e6995385f22ad1639_***_Michael Lewis
author Melitta McNarry
Michael Lewis
author2 Melitta McNarry
Nicholas K. Harrison
Tom Withers
Narendra Chinnappa
Michael Lewis
format Journal article
container_title BMC Pulmonary Medicine
container_volume 17
container_issue 1
publishDate 2017
institution Swansea University
issn 1471-2466
doi_str_mv 10.1186/s12890-017-0364-z
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 1
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description BackgroundLittle is known about the mechanistic basis for the exercise intolerance characteristic of patients with respiratory disease; a lack of clearly defined, distinct patient groups limits interpretation of many studies. The purpose of this pilot study was to investigate the pulmonary oxygen uptake (V.V. O2) response, and its potential determinants, in patients with emphysema and idiopathic pulmonary fibrosis (IPF).MethodsFollowing a ramp incremental test for the determination of peak V.V. O2 and the gas exchange threshold, six emphysema (66 ± 7 years; FEV1, 36 ± 16%), five IPF (65 ± 12 years; FEV1, 82 ± 11%) and ten healthy control participants (63 ± 6 years) completed three repeat, heavy-intensity exercise transitions on a cycle ergometer. Throughout each transition, pulmonary gas exchange, heart rate and muscle deoxygenation ([HHb], patients only) were assessed continuously and subsequently modelled using a mono-exponential with (V.V. O2, [HHb]) or without (HR) a time delay.ResultsThe V.V. O2 phase II time-constant (τ) did not differ between IPF and emphysema, with both groups significantly slower than healthy controls (Emphysema, 65 ± 11; IPF, 69 ± 7; Control, 31 ± 7 s; P &#60; 0.05). The HR τ was slower in emphysema relative to IPF, with both groups significantly slower than controls (Emphysema, 87 ± 19; IPF, 119 ± 20; Control, 58 ± 11 s; P &#60; 0.05). In contrast, neither the [HHb] τ nor [HHb]:O2 ratio differed between patient groups.ConclusionsThe slower V.V. O2 kinetics in emphysema and IPF may reflect poorer matching of O2 delivery-to-utilisation. Our findings extend our understanding of the exercise dysfunction in patients with respiratory disease and may help to inform the development of appropriately targeted rehabilitation strategies.
published_date 2017-01-31T03:40:33Z
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score 11.017797

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