No Cover Image

Journal article 1669 views 177 downloads

The application of large amplitude oscillatory stress in a study of fully formed fibrin clots

T. F. Lamer, B. R. Thomas, D. J. Curtis, N. Badiei, P. R. Williams, K. Hawkins, Rhodri Williams Orcid Logo, Karl Hawkins Orcid Logo, Daniel Curtis Orcid Logo

Physics of Fluids, Volume: 29, Issue: 12, Start page: 121606

Swansea University Authors: Rhodri Williams Orcid Logo, Karl Hawkins Orcid Logo, Daniel Curtis Orcid Logo

Check full text

DOI (Published version): 10.1063/1.4999991

Abstract

The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding...

Full description

Published in: Physics of Fluids
ISSN: 1089-7666
Published: 2017
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa35309
first_indexed 2017-09-18T13:02:52Z
last_indexed 2020-06-01T18:47:17Z
id cronfa35309
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2020-06-01T17:00:40.6799491</datestamp><bib-version>v2</bib-version><id>35309</id><entry>2017-09-18</entry><title>The application of large amplitude oscillatory stress in a study of fully formed fibrin clots</title><swanseaauthors><author><sid>642bf793695f412ed932f1ea4d9bc3f1</sid><ORCID>0000-0002-6912-5288</ORCID><firstname>Rhodri</firstname><surname>Williams</surname><name>Rhodri Williams</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>77c39404a9a98c6e2283d84815cba053</sid><ORCID>0000-0003-0174-4151</ORCID><firstname>Karl</firstname><surname>Hawkins</surname><name>Karl Hawkins</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>e76ff28a23af2fe37099c4e9a24c1e58</sid><ORCID>0000-0002-6955-0524</ORCID><firstname>Daniel</firstname><surname>Curtis</surname><name>Daniel Curtis</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2017-09-18</date><deptcode>EAAS</deptcode><abstract>The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding the structural behaviour of clots formed in blood vessels which are exposed to a wide range of shear stresses. We report, for the first time, that artefacts due to ringing exist in both the sample stress and strain waveforms of a LAOStress measurement which will lead to errors in the calculation of nonlinear viscoelastic properties. The process of smoothing the waveforms eliminates these artefacts whilst retaining essential rheological information. Furthermore, we demonstrate the potential of LAOStress for characterising the nonlinear viscoelastic properties of fibrin clots in response to incremental increases of applied stress up to the point of fracture. Alternating LAOStress and small amplitude oscillatory shear measurements provide detailed information of reversible and irreversible structural changes of the fibrin clot as a consequence of elevated levels of stress. We relate these findings to previous studies involving large scale deformations of fibrin clots. The LAOStress technique may provide useful information to help understand why some blood clots formed in vessels are stable (such as in deep vein thrombosis) and others break off (leading to a life threatening pulmonary embolism).</abstract><type>Journal Article</type><journal>Physics of Fluids</journal><volume>29</volume><journalNumber>12</journalNumber><paginationStart>121606</paginationStart><publisher/><issnElectronic>1089-7666</issnElectronic><keywords/><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2017</publishedYear><publishedDate>2017-12-31</publishedDate><doi>10.1063/1.4999991</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-06-01T17:00:40.6799491</lastEdited><Created>2017-09-18T11:59:32.3665660</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Chemical Engineering</level></path><authors><author><firstname>T. F.</firstname><surname>Lamer</surname><order>1</order></author><author><firstname>B. R.</firstname><surname>Thomas</surname><order>2</order></author><author><firstname>D. J.</firstname><surname>Curtis</surname><order>3</order></author><author><firstname>N.</firstname><surname>Badiei</surname><order>4</order></author><author><firstname>P. R.</firstname><surname>Williams</surname><order>5</order></author><author><firstname>K.</firstname><surname>Hawkins</surname><order>6</order></author><author><firstname>Rhodri</firstname><surname>Williams</surname><orcid>0000-0002-6912-5288</orcid><order>7</order></author><author><firstname>Karl</firstname><surname>Hawkins</surname><orcid>0000-0003-0174-4151</orcid><order>8</order></author><author><firstname>Daniel</firstname><surname>Curtis</surname><orcid>0000-0002-6955-0524</orcid><order>9</order></author></authors><documents><document><filename>0035309-09112017153740.pdf</filename><originalFilename>lamer2017.pdf</originalFilename><uploaded>2017-11-09T15:37:40.5870000</uploaded><type>Output</type><contentLength>6462724</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2017-11-09T00:00:00.0000000</embargoDate><copyrightCorrect>false</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2020-06-01T17:00:40.6799491 v2 35309 2017-09-18 The application of large amplitude oscillatory stress in a study of fully formed fibrin clots 642bf793695f412ed932f1ea4d9bc3f1 0000-0002-6912-5288 Rhodri Williams Rhodri Williams true false 77c39404a9a98c6e2283d84815cba053 0000-0003-0174-4151 Karl Hawkins Karl Hawkins true false e76ff28a23af2fe37099c4e9a24c1e58 0000-0002-6955-0524 Daniel Curtis Daniel Curtis true false 2017-09-18 EAAS The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding the structural behaviour of clots formed in blood vessels which are exposed to a wide range of shear stresses. We report, for the first time, that artefacts due to ringing exist in both the sample stress and strain waveforms of a LAOStress measurement which will lead to errors in the calculation of nonlinear viscoelastic properties. The process of smoothing the waveforms eliminates these artefacts whilst retaining essential rheological information. Furthermore, we demonstrate the potential of LAOStress for characterising the nonlinear viscoelastic properties of fibrin clots in response to incremental increases of applied stress up to the point of fracture. Alternating LAOStress and small amplitude oscillatory shear measurements provide detailed information of reversible and irreversible structural changes of the fibrin clot as a consequence of elevated levels of stress. We relate these findings to previous studies involving large scale deformations of fibrin clots. The LAOStress technique may provide useful information to help understand why some blood clots formed in vessels are stable (such as in deep vein thrombosis) and others break off (leading to a life threatening pulmonary embolism). Journal Article Physics of Fluids 29 12 121606 1089-7666 31 12 2017 2017-12-31 10.1063/1.4999991 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2020-06-01T17:00:40.6799491 2017-09-18T11:59:32.3665660 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering T. F. Lamer 1 B. R. Thomas 2 D. J. Curtis 3 N. Badiei 4 P. R. Williams 5 K. Hawkins 6 Rhodri Williams 0000-0002-6912-5288 7 Karl Hawkins 0000-0003-0174-4151 8 Daniel Curtis 0000-0002-6955-0524 9 0035309-09112017153740.pdf lamer2017.pdf 2017-11-09T15:37:40.5870000 Output 6462724 application/pdf Version of Record true 2017-11-09T00:00:00.0000000 false eng
title The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
spellingShingle The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
Rhodri Williams
Karl Hawkins
Daniel Curtis
title_short The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
title_full The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
title_fullStr The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
title_full_unstemmed The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
title_sort The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
author_id_str_mv 642bf793695f412ed932f1ea4d9bc3f1
77c39404a9a98c6e2283d84815cba053
e76ff28a23af2fe37099c4e9a24c1e58
author_id_fullname_str_mv 642bf793695f412ed932f1ea4d9bc3f1_***_Rhodri Williams
77c39404a9a98c6e2283d84815cba053_***_Karl Hawkins
e76ff28a23af2fe37099c4e9a24c1e58_***_Daniel Curtis
author Rhodri Williams
Karl Hawkins
Daniel Curtis
author2 T. F. Lamer
B. R. Thomas
D. J. Curtis
N. Badiei
P. R. Williams
K. Hawkins
Rhodri Williams
Karl Hawkins
Daniel Curtis
format Journal article
container_title Physics of Fluids
container_volume 29
container_issue 12
container_start_page 121606
publishDate 2017
institution Swansea University
issn 1089-7666
doi_str_mv 10.1063/1.4999991
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding the structural behaviour of clots formed in blood vessels which are exposed to a wide range of shear stresses. We report, for the first time, that artefacts due to ringing exist in both the sample stress and strain waveforms of a LAOStress measurement which will lead to errors in the calculation of nonlinear viscoelastic properties. The process of smoothing the waveforms eliminates these artefacts whilst retaining essential rheological information. Furthermore, we demonstrate the potential of LAOStress for characterising the nonlinear viscoelastic properties of fibrin clots in response to incremental increases of applied stress up to the point of fracture. Alternating LAOStress and small amplitude oscillatory shear measurements provide detailed information of reversible and irreversible structural changes of the fibrin clot as a consequence of elevated levels of stress. We relate these findings to previous studies involving large scale deformations of fibrin clots. The LAOStress technique may provide useful information to help understand why some blood clots formed in vessels are stable (such as in deep vein thrombosis) and others break off (leading to a life threatening pulmonary embolism).
published_date 2017-12-31T07:16:54Z
_version_ 1821932482716499968
score 11.048085

Similar Items