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The application of large amplitude oscillatory stress in a study of fully formed fibrin clots / T. F. Lamer, B. R. Thomas, D. J. Curtis, N. Badiei, P. R. Williams, K. Hawkins, Rhodri Williams, Karl Hawkins, Daniel Curtis

Physics of Fluids, Volume: 29, Issue: 12, Start page: 121606

Swansea University Authors: Rhodri Williams, Karl Hawkins, Daniel Curtis

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DOI (Published version): 10.1063/1.4999991

Abstract

The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding...

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Published in: Physics of Fluids
ISSN: 1089-7666
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa35309
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spelling 2020-06-01T17:00:40.6799491 v2 35309 2017-09-18 The application of large amplitude oscillatory stress in a study of fully formed fibrin clots 642bf793695f412ed932f1ea4d9bc3f1 0000-0002-6912-5288 Rhodri Williams Rhodri Williams true false 77c39404a9a98c6e2283d84815cba053 0000-0003-0174-4151 Karl Hawkins Karl Hawkins true false e76ff28a23af2fe37099c4e9a24c1e58 0000-0002-6955-0524 Daniel Curtis Daniel Curtis true false 2017-09-18 CHEG The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding the structural behaviour of clots formed in blood vessels which are exposed to a wide range of shear stresses. We report, for the first time, that artefacts due to ringing exist in both the sample stress and strain waveforms of a LAOStress measurement which will lead to errors in the calculation of nonlinear viscoelastic properties. The process of smoothing the waveforms eliminates these artefacts whilst retaining essential rheological information. Furthermore, we demonstrate the potential of LAOStress for characterising the nonlinear viscoelastic properties of fibrin clots in response to incremental increases of applied stress up to the point of fracture. Alternating LAOStress and small amplitude oscillatory shear measurements provide detailed information of reversible and irreversible structural changes of the fibrin clot as a consequence of elevated levels of stress. We relate these findings to previous studies involving large scale deformations of fibrin clots. The LAOStress technique may provide useful information to help understand why some blood clots formed in vessels are stable (such as in deep vein thrombosis) and others break off (leading to a life threatening pulmonary embolism). Journal Article Physics of Fluids 29 12 121606 1089-7666 31 12 2017 2017-12-31 10.1063/1.4999991 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2020-06-01T17:00:40.6799491 2017-09-18T11:59:32.3665660 College of Engineering Engineering T. F. Lamer 1 B. R. Thomas 2 D. J. Curtis 3 N. Badiei 4 P. R. Williams 5 K. Hawkins 6 Rhodri Williams 0000-0002-6912-5288 7 Karl Hawkins 0000-0003-0174-4151 8 Daniel Curtis 0000-0002-6955-0524 9 0035309-09112017153740.pdf lamer2017.pdf 2017-11-09T15:37:40.5870000 Output 6462724 application/pdf Version of Record true 2017-11-09T00:00:00.0000000 false eng
title The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
spellingShingle The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
Rhodri, Williams
Karl, Hawkins
Daniel, Curtis
title_short The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
title_full The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
title_fullStr The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
title_full_unstemmed The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
title_sort The application of large amplitude oscillatory stress in a study of fully formed fibrin clots
author_id_str_mv 642bf793695f412ed932f1ea4d9bc3f1
77c39404a9a98c6e2283d84815cba053
e76ff28a23af2fe37099c4e9a24c1e58
author_id_fullname_str_mv 642bf793695f412ed932f1ea4d9bc3f1_***_Rhodri, Williams
77c39404a9a98c6e2283d84815cba053_***_Karl, Hawkins
e76ff28a23af2fe37099c4e9a24c1e58_***_Daniel, Curtis
author Rhodri, Williams
Karl, Hawkins
Daniel, Curtis
author2 T. F. Lamer
B. R. Thomas
D. J. Curtis
N. Badiei
P. R. Williams
K. Hawkins
Rhodri Williams
Karl Hawkins
Daniel Curtis
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container_title Physics of Fluids
container_volume 29
container_issue 12
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publishDate 2017
institution Swansea University
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description The suitability of controlled stress large amplitude oscillatory shear (LAOStress) for the characterisation of the nonlinear viscoelastic properties of fully formed fibrin clots is investigated. Capturing the rich nonlinear viscoelastic behaviour of the fibrin network is important for understanding the structural behaviour of clots formed in blood vessels which are exposed to a wide range of shear stresses. We report, for the first time, that artefacts due to ringing exist in both the sample stress and strain waveforms of a LAOStress measurement which will lead to errors in the calculation of nonlinear viscoelastic properties. The process of smoothing the waveforms eliminates these artefacts whilst retaining essential rheological information. Furthermore, we demonstrate the potential of LAOStress for characterising the nonlinear viscoelastic properties of fibrin clots in response to incremental increases of applied stress up to the point of fracture. Alternating LAOStress and small amplitude oscillatory shear measurements provide detailed information of reversible and irreversible structural changes of the fibrin clot as a consequence of elevated levels of stress. We relate these findings to previous studies involving large scale deformations of fibrin clots. The LAOStress technique may provide useful information to help understand why some blood clots formed in vessels are stable (such as in deep vein thrombosis) and others break off (leading to a life threatening pulmonary embolism).
published_date 2017-12-31T03:54:39Z
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