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Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring

Anthony E.G. Cass, Sanjiv Sharma Orcid Logo

Enzymes as Sensors, Volume: 589, Pages: 413 - 427

Swansea University Author: Sanjiv Sharma Orcid Logo

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Abstract

Microneedle enzyme sensors by virtue of their minimally invasive and hence pain-free penetration of skin allow for the measurement of metabolites, biomarkers, and drugs in the interstitial fluid that bathes the dermal tissue. Such devices if they are to be adopted widely into clinical practice need...

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Published in: Enzymes as Sensors
ISBN: 9780128054062
ISSN: 0076-6879 1557-7988
Published: Elsevier 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa36254
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first_indexed 2017-10-25T19:11:56Z
last_indexed 2018-02-09T05:28:19Z
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spelling 2017-10-25T15:59:12.9764740 v2 36254 2017-10-25 Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2017-10-25 MEDE Microneedle enzyme sensors by virtue of their minimally invasive and hence pain-free penetration of skin allow for the measurement of metabolites, biomarkers, and drugs in the interstitial fluid that bathes the dermal tissue. Such devices if they are to be adopted widely into clinical practice need to be capable of delivering reliable measurements over extended periods of time (days) and to be fabricated by low-cost, scalable methods. Using injection molding of the base structures in polycarbonate, metal film deposition by sputtering and enzyme immobilization by electrodeposition can meet these requirements. The workflow to produce devices for clinical evaluation is then completed by sterilization and packaging. In vitro evaluation of the sensors’ response to varying analyte concentrations and their mechanical testing establish performance and safety characteristics. While most of the work is focused on glucose sensing, reflecting the significance of the global diabetes “epidemic,” the microneedles can also be used to measure lactate (another metabolite) and theophylline (a therapeutic drug). Book chapter Enzymes as Sensors 589 413 427 Elsevier 9780128054062 0076-6879 1557-7988 Injection moldingElectropolymerizationDiabetesContinuous glucose monitoring 31 12 2017 2017-12-31 10.1016/bs.mie.2017.02.002 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2017-10-25T15:59:12.9764740 2017-10-25T14:06:21.7741406 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Anthony E.G. Cass 1 Sanjiv Sharma 0000-0003-3828-737X 2
title Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring
spellingShingle Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring
Sanjiv Sharma
title_short Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring
title_full Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring
title_fullStr Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring
title_full_unstemmed Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring
title_sort Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring
author_id_str_mv b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Sanjiv Sharma
author2 Anthony E.G. Cass
Sanjiv Sharma
format Book chapter
container_title Enzymes as Sensors
container_volume 589
container_start_page 413
publishDate 2017
institution Swansea University
isbn 9780128054062
issn 0076-6879
1557-7988
doi_str_mv 10.1016/bs.mie.2017.02.002
publisher Elsevier
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
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description Microneedle enzyme sensors by virtue of their minimally invasive and hence pain-free penetration of skin allow for the measurement of metabolites, biomarkers, and drugs in the interstitial fluid that bathes the dermal tissue. Such devices if they are to be adopted widely into clinical practice need to be capable of delivering reliable measurements over extended periods of time (days) and to be fabricated by low-cost, scalable methods. Using injection molding of the base structures in polycarbonate, metal film deposition by sputtering and enzyme immobilization by electrodeposition can meet these requirements. The workflow to produce devices for clinical evaluation is then completed by sterilization and packaging. In vitro evaluation of the sensors’ response to varying analyte concentrations and their mechanical testing establish performance and safety characteristics. While most of the work is focused on glucose sensing, reflecting the significance of the global diabetes “epidemic,” the microneedles can also be used to measure lactate (another metabolite) and theophylline (a therapeutic drug).
published_date 2017-12-31T03:43:13Z
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