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Aptamer-based biosensors for the rapid visual detection of flu viruses

T. T. Le, B. Adamiak, D. J. Benton, C. J. Johnson, Sanjiv Sharma Orcid Logo, R. Fenton, J. W. McCauley, M. Iqbal, A. E. G. Cass

Chem. Commun., Volume: 50, Issue: 98, Pages: 15533 - 15536

Swansea University Author: Sanjiv Sharma Orcid Logo

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DOI (Published version): 10.1039/C4CC07888H

Abstract

RNA aptamers showing affinity and specificity for different strains of human influenza virus were assembled onto gold nanoparticles that subsequently formed a gold nanoshell (AuNS) around the viral envelope. These shells could be visualised by transmission electron microscopy (TEM). Changes in size...

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Published in: Chem. Commun.
ISSN: 1359-7345 1364-548X
Published: 2014
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URI: https://cronfa.swan.ac.uk/Record/cronfa36440
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first_indexed 2017-11-01T19:54:03Z
last_indexed 2020-07-01T18:50:30Z
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spelling 2020-07-01T16:23:38.4328603 v2 36440 2017-11-01 Aptamer-based biosensors for the rapid visual detection of flu viruses b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2017-11-01 MEDE RNA aptamers showing affinity and specificity for different strains of human influenza virus were assembled onto gold nanoparticles that subsequently formed a gold nanoshell (AuNS) around the viral envelope. These shells could be visualised by transmission electron microscopy (TEM). Changes in size and structure of the AuNS coated virus can be used to detect the viruses. We show that sedimentation with a low cost centrifuge and visual determination can detect 3 × 108 viral particles. Journal Article Chem. Commun. 50 98 15533 15536 1359-7345 1364-548X 31 12 2014 2014-12-31 10.1039/C4CC07888H http://pubs.rsc.org/-/content/articlelanding/2014/cc/c4cc07888h/unauth#!divAbstract COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-07-01T16:23:38.4328603 2017-11-01T16:25:09.0785996 T. T. Le 1 B. Adamiak 2 D. J. Benton 3 C. J. Johnson 4 Sanjiv Sharma 0000-0003-3828-737X 5 R. Fenton 6 J. W. McCauley 7 M. Iqbal 8 A. E. G. Cass 9
title Aptamer-based biosensors for the rapid visual detection of flu viruses
spellingShingle Aptamer-based biosensors for the rapid visual detection of flu viruses
Sanjiv Sharma
title_short Aptamer-based biosensors for the rapid visual detection of flu viruses
title_full Aptamer-based biosensors for the rapid visual detection of flu viruses
title_fullStr Aptamer-based biosensors for the rapid visual detection of flu viruses
title_full_unstemmed Aptamer-based biosensors for the rapid visual detection of flu viruses
title_sort Aptamer-based biosensors for the rapid visual detection of flu viruses
author_id_str_mv b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Sanjiv Sharma
author2 T. T. Le
B. Adamiak
D. J. Benton
C. J. Johnson
Sanjiv Sharma
R. Fenton
J. W. McCauley
M. Iqbal
A. E. G. Cass
format Journal article
container_title Chem. Commun.
container_volume 50
container_issue 98
container_start_page 15533
publishDate 2014
institution Swansea University
issn 1359-7345
1364-548X
doi_str_mv 10.1039/C4CC07888H
url http://pubs.rsc.org/-/content/articlelanding/2014/cc/c4cc07888h/unauth#!divAbstract
document_store_str 0
active_str 0
description RNA aptamers showing affinity and specificity for different strains of human influenza virus were assembled onto gold nanoparticles that subsequently formed a gold nanoshell (AuNS) around the viral envelope. These shells could be visualised by transmission electron microscopy (TEM). Changes in size and structure of the AuNS coated virus can be used to detect the viruses. We show that sedimentation with a low cost centrifuge and visual determination can detect 3 × 108 viral particles.
published_date 2014-12-31T03:45:35Z
_version_ 1763752159621414912
score 10.997433

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