Journal article 1217 views 205 downloads
Evaluation of diffusion weighted imaging in the context of multi-parametric MRI of the prostate in the assessment of suspected low volume prostatic carcinoma
Jonathan Phillips,
Ioannis Papadopoulos,
Jonathan Phillips,
Rhodri Evans,
Neil Fenn,
Sophie Shermer 
Magnetic Resonance Imaging, Volume: 47, Pages: 131 - 136
Swansea University Authors:
Jonathan Phillips, Sophie Shermer
DOI (Published version): 10.1016/j.mri.2017.11.014
Abstract
Data from a multi-parameteric MRI study of patients with possible early-stage prostate cancer was assessed with a view to creating an efficient clinical protocol. Based on a correlation analysis suggesting that diffusion-weighted imaging (DWI) scores are more strongly correlated with overall PIRADS...
| Published in: | Magnetic Resonance Imaging |
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| ISSN: | 0730725X |
| Published: |
2018
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa37301 |
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| Abstract: |
Data from a multi-parameteric MRI study of patients with possible early-stage prostate cancer was assessed with a view to creating an efficient clinical protocol. Based on a correlation analysis suggesting that diffusion-weighted imaging (DWI) scores are more strongly correlated with overall PIRADS scores than other modalities such as dynamic contrast enhanced imaging or spectroscopy, we investigate the combination of T2-weighted imaging (T2w) and DWI as a potential diagnostic tool for prostate cancer detection, staging and guided biopsies. Quantification of the noise floor in the DWI images and careful fitting of the data suggests that the mono-exponential model provides a very good fit to the data and there is no evidence of non-Guassian diffusion for b-values up to 1000 s/mm2. This precludes the use of kurtosis or other non-Gaussian measures as a biomarker for prostate cancer in our case. However, the ADC scores for healthy and probably malignant regions are significantly lower for the latter in all 20 but one patient. The results suggest that a simplified mp-MRI protocol combining T2w and DWI may be a good compromise for a cost and time efficient, early-stage prostate cancer diagnostic programme, combining robust MR biomarkers for prostate cancer that can be reliably quantified and appear well-suited for general clinical practice. |
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| Keywords: |
MRI, DWI, Prostate Cancer, PIRADS |
| College: |
Faculty of Science and Engineering |
| Start Page: |
131 |
| End Page: |
136 |